Finding the rules for successful drug optimisation
Summary In this drug optimisation article, co-authored with Pfizer we discuss new ‘rule induction’ methods. These explore complex data to…
A complete platform for molecular design, optimisation and data analysis
How does StarDrop support your hit-to-candidate process?
Easy SAR analysis
Clear data visualisation
Multi-parameter optimisation
Intuitive Card View®
Dynamic Glowing Molecule™
Seamless AI insights
Tailored to you
Access a huge range of customisation and integration options to build the workflow you need. Plug-in modules for in silico modelling, generative chemistry or 3D design; collaborative drug design extensions; in-house and external database integration. Whatever you need for your workflow, StarDrop can help.
We’re delivering trust
Thank you to some of our StarDrop users, listed below, who testify to the impact of the platform on their discovery programs
Discover StarDrop Modules
ADME QSAR
High quality predictive QSAR models of a broad range of key ADME and physicochemical properties
Metabolism
Quickly identify metabolic pathways, potential metabolites and guide compound design to avoid metabolic liabilities
Derek Nexus
Knowledge-based prediction of over 40 key toxicity endpoints, helping guide the design of safe, efficacious drugs
Auto-Modeller
Build and validate robust QSAR models tailored to your chemistry and data, in an easy and intuitive way
Nova
Generate and prioritise new, relevant compound ideas using virtual library enumeration and generative chemistry
BIOSTER
Access a world of chemistry experience, extending Nova’s capabilities with over 29,000 structure modifications and replacement techniques
Inspyra
Combine your expert chemistry knowledge and the exploratory power of generative methods to identify optimal compounds faster
eSim3D
3D ligand-based design – understand binding conformations to identify and optimise novel active compounds
SeeSAR
3D structure-based design – visualise ligand and protein structures and identify key interactions driving binding affinity
MPO Explorer
Develop multi-parameter optimisation strategies using patented rule induction and sensitivity analysis methods
In silico modelling
ADME QSAR
High quality predictive QSAR models of a broad range of key ADME and physicochemical properties
Metabolism
Quickly identify metabolic pathways, potential metabolites and guide compound design to avoid metabolic liabilities
Derek Nexus
Knowledge-based prediction of over 40 key toxicity endpoints, helping guide the design of safe, efficacious drugs
Auto-Modeller
Build and validate robust QSAR models tailored to your chemistry and data, in an easy and intuitive way
Generative chemistry
Nova
Generate and prioritise new, relevant compound ideas using virtual library enumeration and generative chemistry
BIOSTER
Access a world of chemistry experience, extending Nova’s capabilities with over 29,000 structure modifications and replacement techniques
Inspyra
Combine your expert chemistry knowledge and the exploratory power of generative methods to identify optimal compounds faster
Linking 2D and 3D SAR and design
eSim3D
3D ligand-based design – understand binding conformations to identify and optimise novel active compounds
SeeSAR
3D structure-based design – visualise ligand and protein structures and identify key interactions driving binding affinity
MPO Strategy
MPO Explorer
Develop multi-parameter optimisation strategies using patented rule induction and sensitivity analysis methods
Supporting customisation and collaboration
Idea Tracker
Accelerate your drug discovery projects with collaborative design, centralised sharing and informed decision-making.
Customisation and Integration
Comprehensive data analysis, visualisation and design, easily integrated into your informatics infrastructure.
3D docking and Alignment
Integrated access to 3D modelling to analyse SAR, identify potential liabilities and guide compound design.
Database Access
Seamlessly connect to your in-house databases, with a user-friendly interface to access the latest and most relevant data.
Flexible Deployment
Enjoy identical functionality and user experience, with options for desktop or cloud-based StarDrop, and several hosted server options.
We have recently switched to StarDrop from Optibrium and it has been super user friendly.
Co-Founder and Chief Science Officer, Sunflower Wellness
StarDrop is a very compelling package – multiple powerful tools combined into a single piece of software accessed via a very intuitive user interface. The ease with which powerful MPO scoring functions and QSAR models can be generated and applied to new ideas, as well as the ability to predict metabolic liabilities, make StarDrop the go-to software for ensuring project progression.
Medicinal Chemist, Evotec
We routinely use StarDrop to visualise complex multi-parameter datasets, which helps inform the next stage of medicinal chemistry design. The user-friendly interface makes data analysis and property prediction easily accessible to medicinal chemists. A great drug discovery tool!
Director, Cerevance
Optibrium tools have proven instrumental during our lead optimization programs and beyond. Particularly, the metabolism module provided valuable guidance on design level during optimization cycles and substantially accelerated structure elucidation during Met-ID studies.
Head of Chemistry, Basilea
We use StarDrop for numerous functions, from the mundane to the elaborate. It’s an incredibly user-friendly, yet powerful piece of software… Our usage spans the entire medicinal chemistry spectrum; from hit triage to the processing of pre-clinical data.
Anima Biotech
StarDrop is a fantastic tool to have as a medicinal chemist, whether you do early-stage medicinal chemistry or deal with a huge amount of data. It’s super quick – I can have a view on my SAR within five minutes, to inform future design strategies.
Medicinal Chemist, adMare Bioinnovations
I really would like to give a big thumbs up to StarDrop and your team. StarDrop is a powerful package tool with an intuitive user interface to access and operate. We really appreciate the visualization module and probabilistic scoring system, which can well-organized interactive charts, graphics and chemical space to facilitate our understanding of the SAR in our chemical series.
Investigator, IFF
The relative ease of use of StarDrop, compared to other drug design and discovery software, allows my students to quickly focus on essential topics, such as ADME, QSAR, metabolism studies, and protein-ligand docking.
Instructor of Chemistry, North Carolina School of Science and Mathematics
How much will StarDrop cost me?
The answer is, it depends. Our CCO, James, explains which factors influence the cost of drug discovery platforms.
StarDrop resources
Perfecting the use of imperfect QSAR models
In this webinar, we examine the effective use of QSAR modelling in drug discovery and discuss a variety of pain points for medicinal chemists in knowing when a model can be trusted and how to avoid common pitfalls.
Matched Series for SAR Analysis
Try Matched Series Analysis in this follow-along tutorial
StarDrop in action case studies
Ready to transform to data-driven decision making and trial StarDrop?
Simply complete the form now for a free personalised demo and see how StarDrop fits your unique research needs.
If you’d like to find out more about the StarDrop evaluation process read our step-by-step guide.
Keen to find what factors will impact the cost of StarDrop?
Our CCO, James Halle, talks about key considerations when budgeting for drug discovery software.