A Novel Scoring Profile for the Design of Antibacterials Active Against Gram-Negative Bacteria
At the 2nd SCI/RSC Symposium on Antimicrobial Drug Discovery, 12-13 November 2018, Bailey Montefiore, Optibrium – Franca Klingler, BioSolveIT – Nicholas Foster, Optibrium presented ‘A Novel Scoring Profile for the Design of Antibacterials Active Against Gram-Negative Bacteria’.
The increasing occurrence of multidrug-resistant bacteria is one of the major global threats to human health. Design of new antibacterials is challenging because new compound classes often do not possess the unique physicochemical properties required to penetrate the gram-negative cell wall. It is accepted that the physicochemical properties of many drugs are similar and attempts have been made to characterise these ‘drug-like’ properties, such as Lipinski’s ‘rule of five’ for orally dosed drugs. However, antibiotics are a known exception to these rules. We compared antibiotics active against gram-negative bacteria with other classes of drug and compounds considered in medicinal chemistry projects to determine criteria for selection of compounds with a higher chance of success as a gram-negative antibacterial. These criteria are based on calculated properties, so can help to guide the design and selection of compounds in discovery projects.
You can download the poster presentation as a PDF