This example explores some of the challenges typically encountered in scaffold-based library design, in particular the task of creating reagent fragments (clipping) for use in scaffold-based library enumeration. Using StarDrop’s R-group clipping tool, we will quickly transform chemical building blocks into their corresponding substituents, ready to enumerate a virtual library in StarDrop’s Nova module.

To try this example yourself, download the example project file and follow the step-by-step guidelines in this PDF.

Please note that the tutorial explores core features of StarDrop. If you don’t have access to StarDrop and would like to arrange a free trial license, please email us at info@optibrium.com

This video was recorded with the latest version of StarDrop. If you are going through this tutorial yourself with an older version of StarDrop, the results will appear slightly differently, due to changes in the underlying knowledgebase. Therefore, if you would like an older version of the PDF instructions to match your StarDrop version, please contact support@optibrium.com.