R-group Clipping of Reagents for Library Enumeration

May 18, 2022

R-group Clipping of Reagents for Library Enumeration

This example explores some of the challenges typically encountered in scaffold-based library design, in particular the task of creating reagent fragments (clipping) for use in scaffold-based library enumeration. Using StarDrop’s R-group clipping tool, we will quickly transform chemical building blocks into their corresponding substituents, ready to enumerate a virtual library in StarDrop’s Nova module.

To try this example yourself, download the example project file and follow the step-by-step guidelines in this PDF.

Please note that the tutorial explores core features of StarDrop. If you don’t have access to StarDrop and would like to arrange a free trial license, please email us at [email protected]