MPO Explorer: Sensitivity Analysis
In this example, we will use the Sensitivity Analysis tool in StarDrop’s MPO Explorer module to check if the ranking of compounds in a data set is sensitive to any of the criteria or importance values in a scoring profile. This is important to consider because, if the compounds we would choose are very sensitive to a property criterion, we should carefully consider if this criterion is appropriate to avoid missing potentially valuable opportunities. This analysis can also help to determine if different values for a criterion would have an impact on the strategy for a project, for example if there is a disagreement regarding the most appropriate criterion to use. If the ranking of compounds is essentially unchanged within a reasonable range of values, this means that the scoring profile can be used with confidence that the ultimate selection will be robust to the chosen criteria.
To try this example yourself, download the example data file and follow the step-by-step guidelines in this PDF.
Please note that the tutorial explores core features of StarDrop and the MPO Explorer module. If you don’t have access to this module and would like to arrange a free trial license, please email us at [email protected]
You can also watch a video of this tutorial here but others that might interest you can be found in the tutorials section of our video archive.
Please note that this video was recorded with an earlier version of StarDrop, so there may be small differences in appearance, however the process demonstrated is unchanged.