This example explores some of the challenges typically encountered in scaffold-based library design, in particular the task of creating reagent fragments (clipping) for use in scaffold-based library enumeration.

Using StarDrop’s R-group clipping tool, we will quickly transform chemical building blocks into their corresponding substituents, ready to enumerate a virtual library in StarDrop’s Nova module.

Depending on which version of StarDrop you have the results may appear slightly differently, due to changes in the underlying knowledgebase. Therefore, if you would like a different version of the PDF instructions to match your StarDrop version, please contact

Would you like to try it yourself?

To try this example yourself, download the example project file and follow the step-by-step guidelines.

Please note that the tutorial explores core features of StarDrop and the Nova module. If you don’t have access to StarDrop and would like to arrange a trial, please email us at

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