StarDrop Modules


A world of chemistry experience
  • Rigorously explore the chemistry around hits
  • Library of nearly 30,000 precedented transformations
  • Optional extension to StarDrop’s Nova module
Bioster StarDrop Module cover

Variations on a theme

Nova can generate new ideas to exponentially broaden your search by taking a ‘parent’ molecule and creating new generations of related compounds. Using a built-in collection of over 200 typical ‘medicinal chemistry transformations’, Nova explores generations of potential ‘children’. This library may be extended with your own transformations or the optional BIOSTER database, providing almost 30,000 structure modifications and replacement techniques that have been used in analogue design.

A comprehensive collection of chemically and synthetically validated transformations

BIOSTER brings the collective experience of the chemistry community to help you to discover new active analogues of your compounds. The BIOSTER module contains a unique compilation of nearly 30,000 transformations encompassing a broad range of optimisation strategies, including bioisosteric replacements, linker replacements, homologization, introduction of conformational constraints and reversible derivatizations (e.g.prodrugs). These are manually curated from the literature by Dr István Ujváry and are provided complete with references to the original publications in which they are described, making it easy to follow-up the underlying chemistry and biological data.

Transform your chemistry

BIOSTER is developed and updated in collaboration with iKem Szolgáltató és Kereskedelmi BT and is available as an optional extension to StarDrop’s Nova module. This combination enables you to quickly and easily search the comprehensive BIOSTER database to identify transformations that are relevant to your compounds. These can be automatically applied to generate novel structures with a high likelihood of biological activity and synthetic accessibility, prioritised against the property profile you require for your project.

The BIOSTER database is available as an optional add on to the Nova module for StarDrop. To find out more about StarDrop and the BIOSTER database, to arrange an online demonstration or to try StarDrop for yourself, please contact us.

Discover StarDrop™

With its comprehensive suite of integrated software, StarDrop™ delivers best-in-class in silico technologies within a highly visual and user-friendly interface. StarDrop™ enables a seamless flow from the latest data through predictive modelling to decision-making regarding the next round of synthesis and research, improving the speed, efficiency, and productivity of the discovery process.

BIOSTER is available as optional module for StarDrop.  To trial StarDrop please complete the form and a member of the team will get in touch to understand your needs and get you set-up with a licence that works best for you.


Plug-in Modules

StarDrop's™ core features can be extended with a comprehensive range of optional plug-in modules; predictive models for ADME properties, Phase I and II metabolic routes and toxicity; automatic QSAR model building; 3D SAR analysis; and de novo design to stimulate the search for new optimisation strategies.


Quickly identify metabolic pathways, potential metabolites and guide compound design to avoid metabolic liabilities.

Derek Nexus

Knowledge-based prediction of over 40 toxicity endpoints


High quality predictive QSAR models of key ADME properties


Build and validate robust QSAR models tailored to your chemistry and data


Generate & prioritise new, relevant compound ideas


A world of chemistry experience


Inspyra™ combines your expert chemistry knowledge and the exploratory power of generative methods to help you identify optimal compounds faster.

Surflex eSim3D

3D ligand-based design – understand binding conformations to identify and optimise novel active compounds


3D Structure-based design

MPO Explorer

Develop multi-parameter optimisation strategies