There are a number of criteria to balance when looking to select a successful drug candidate. But how can we consider the impact of the compound selection criteria we choose on the decisions we make?
Summary
This peer-reviewed article, published in the Journal of Medicinal Chemistry, describes how identifying sensitive criteria can highlight new avenues for exploration, and assist us in avoiding missed opportunities.
It highlights how uncertainty in predictions of particularly important property criteria can lead to valuable opportunities being missed. The authors present a new method to analyse the sensitivity of compound selection and prioritisation to a multi-parameter scoring profile of property criteria.
Citation details
M. D. Segall, I. Yusof, and E. J. Champness, J. Med. Chem. 2016, 59, 9, 4267–4277