This review article discusses recent developments in the methods and opinions around multi-parameter optimisation, focusing on applications to de novo drug design and illustrated with published examples. Read now to discover more on the latest advances in multi-parameter optimisation methods.
M. D. Segall, Expert Opinion in Drug Discovery, 2014, 9(7) pp. 803-817
DOI: 10.1517/17460441.2014.913565
Watch our webinar on ‘Multi-parameter optimisation in practice‘ for more information about multi-parameter optimisation methods, or try multi-parameter optimisation for yourself with our tutorial example.
This peer-reviewed article, published in the Journal of Medicinal Chemistry, describes how identifying sensitive criteria can highlight new avenues for exploration, and assist us in avoiding missed opportunities
In this example, we will use the Sensitivity Analysis tool in StarDrop’s MPO Explorer module to check if the ranking of compounds in a data set is sensitive to any of the criteria or importance values in a scoring profile.
In this multi-parameter optimisation review, we survey the range of methods used for MPO in drug discovery, compare their strengths…
