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Publications & Presentations

Predicting Pharmacokinetic Parameters and Curves

Thursday, 12 November 2020 09:34
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Matt Segall

Held on 11 November 2020.

Predicting Pharmacokinetic Parameters and Curves

This webinar was presented by Matt Segall, Tom Whitehead (Intellegens), Nigel Greene (AstraZeneca) and John Norman.

Pharmacokinetics (PK) describes how the body affects a drug after administration. The concentration-time profile of a compound reflects its exposure, duration of action, safety margin and other critical factors affecting the success of a potential drug.

Accurate predictions of PK would enable better decisions regarding the selection of compounds for in vivo studies, reducing the number of experiments required and the associated cost. But, this is particularly challenging because in vivo PK is influenced by many biological mechanisms.

In this webinar, Tom Whitehead from Intellegens, describes the successful application of the Alchemite™ method for deep learning imputation to the prediction of PK parameters, based on compound structure and sparse in vitro data.

This project was undertaken in collaboration with AstraZeneca and we were delighted to be joined by Nigel Greene, AZ’s Director of Data Science & AI, who discussed their research in this area.

To hear the narration, please increase your speaker volume.

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