There are many different definitions of ‘drug-like’, with rules proposed based on property trends seen in successful drugs. In the paper we review the strengths and weaknesses of these different definitions of ‘drug-like’ properties and measures of ‘drug-likeness.’ We propose an alternative metric the Relative Drug Likelihood (RDL) that identifies the properties with the greatest impact on a compound’s likelihood of success for a drug discovery objective.

Citation details

I. Yusof, M. D. Segall, Drug Discovery Today, 2013, 18(13-14), 659-666

DOI: 10.1016/j.drudis.2013.02.008

Drug-like properties model

To help you get a quantitative estimate of drug-likeness (based off the Bickerton et al. 2012 article), check out the StarDrop download, available to support your projects now.

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