Senior or Principal Scientist – 3D Molecular Modelling

Founded in 2009 and headquartered in Cambridge, UK, Optibrium develops software and novel technologies to improve the efficiency and productivity of drug discovery. Our solutions support industry-leading research for a global customer base, including top ten pharma and innovative biotech companies. Optibrium software solutions include

• StarDrop™ – A complete package of fully integrated software for multi-objective small molecule design, optimisation, and data analysis;
• Cerella™ – A unique platform for the imputation of drug discovery data, revealing insights into the best compounds and most valuable experiments; and
• BioPharmics™ – A fast, robust, and accurate 3D ligand- and structure-based design platform that scales from small molecules to large macrocycles.

With a strong track record of translating peer-reviewed science into successful products and a growing blue-chip customer base for BioPharmics, we are recruiting a Senior or Principal Scientist – 3D Molecular Modelling to help customers achieve challenging drug discovery objectives and maximise the value of our software.

About the Role

As a Senior or Principal Scientist you will:

• Apply 3D structure-based and ligand-based design approaches to lead discovery and optimisation
• Support current and prospective customers in the effective use of BioPharmics, working with the commercial team to communicate its value clearly and scientifically
• Use NMR and X-ray crystallography data in combination with the BioPharmics modelling methods
• Provide guidance on the development of the BioPharmics platform by identifying unmet customer needs and translating them into product and research opportunities
• Represent Optibrium’s science and products at conferences, workshops, and customer meetings

About You

The ideal candidate will have the following experience:

• PhD in computational chemistry, computer science, chemistry, biophysics, or a related discipline
• Strong understanding of structure-based and ligand-based drug design, ideally including experience with macrocycles and peptides
• Experience with molecular modelling and visualisation platforms (e.g., PyMOL and MOE)
• Experience with structural data (NMR and X-ray crystallography) applied to molecular design problems
• A track record of high-quality peer-reviewed publications and conference presentations
• The ability to work effectively with customers, collaborators, and cross-functional teams

What We Offer

We offer hybrid & flexible working, a competitive base salary, pension contribution, employee private medical and dental cover, life assurance, corporate gym discount and cycle to work scheme.

If you’re interested in joining a growing, entrepreneurial team working in an exciting field, please apply with a CV and covering letter to vacancies@optibrium.com (unsolicited applications from agencies will not be accepted).