Date: 15th April (Wednesday)
Time: EMEA – 9am BST | 10am CEST || Americas – 10am PDT | 1pm EDT
What’s the challenge?
Once you’ve identified promising hits, you’ll often need to broaden the chemistry to improve key properties. However, optimising for a single property in isolation risks introducing liabilities elsewhere.
What you’ll learn
We’ll work through a typical optimisation scenario, starting with a compound series that has a strong ADME profile but insufficient target inhibition. You’ll see how you can use Nova’s chemistry transformations derived from literature to generate new compound ideas that improve potency whilst preserving your desired balance of properties.
You’ll also learn how to manage the generative process to produce focused, actionable results. We’ll demonstrate practical strategies for navigating hundreds of thousands of possible transformations to find the compounds most relevant to your project objectives.
Featured StarDrop module: Nova™