Optibrium Community


SpotRM Plug-in for StarDrop

Jul 5, 2022

SpotRM Plug-in for StarDrop

Jul 5, 2022

This script enables you to search SpotRM to identify the structural features of your molecules that might lead to the formation of reactive metabolites; for a background to the application, see this website. The search returns the most important structural alerts identified along with their severities, plus links to short monographs and literature resources that describe the adverse drug effects associated with the alert. To use this tool, you will need login credentials which are supplied at the SpotRM registration site.

Please note that any compound structures used in a query will be passed to the SpotRM servers. These data will be sent using a secure connection (i.e. transmitted via HTTPS).  You can learn more from the SpotRM data security overview.

The installer file and instructions for how to install and use the script are provided in the following pages…


Please note: These scripts are compatible with StarDrop 7.3, or more recent versions, for either Windows® or MacOS®. To find out which version you have installed, start StarDrop and select the Help->About menu. If you are using an older version of StarDrop, please contact stardrop-support@optibrium.com and we will be happy to provide download details.


We have recently updated StarDrop’s scripting to make it easier for everyone to download and install scripts without needing administrator privileges. If you are already using custom scripts that you downloaded and installed while using a previous version of StarDrop, then you will need to download these again (they have all been updated) and follow the installation instructions. If you are using any in-house scripts to access internal systems or databases, or are uncertain about what to do, then please contact StarDrop Support for assistance.


To install this script on Windows:

  • Ensure that you have saved your work and close StarDrop
  • For 64-bit Windows, download the file StarDrop Script – SpotRM.exe
  • When the download is complete, double-click the file to run it and follow the instructions (we recommend that you accept the default options provided)
  • Restart StarDrop


To install this script on macOS:

  • Ensure that you have saved your work and close StarDrop
  • Download the file StarDrop Script – SpotRM.zip
  • In your user area, navigate to the StarDrop folder (~/StarDrop/py3)
  • Extract the contents of the zip file into this folder overwriting any existing files
  • You should now see a folder called SpotRM and a folder called Utils in the py folder.
  • Restart StarDrop

To use this script…

…you must first register for a SpotRM username and password at https://www.spotrm.com. Registration gives you 24 hours free access but also triggers the licensing dialogue with Awametox AB who developed the site. Having registered, click on the Custom Scripts->SpotRM analysis menu item in StarDrop to run the SpotRM alerts search for the molecules in your dataset.

The first time you start a search, you will be prompted to log in, but you’ll only need to do this once in each StarDrop session or after an hour’s inactivity to refresh your credentials.