Guiding Selection and Design in Hit-to-Lead
The objective in this example is to identify one or more high quality chemistries for progression to detailed in vitro and in vivo studies, based on initial screening data for potency; ideally the compounds chosen for progression should not only be potent, but also have appropriate ADME properties to result in a high quality lead series. We will also use StarDrop to explore potential modification of one of the existing compounds to improve its properties.
Please note that the tutorial explores core features of StarDrop and the ADME QSAR module. If you don’t have access to this module and would like to arrange a free trial license, please email us at firstname.lastname@example.org
You can also watch a video of this tutorial here, others that might interest you can be found in the tutorials section of our video archive.