Manifold, developed by PostEra, is a web-based tool that allows chemists to assess the synthetic feasibility of novel compounds and proposes routes for synthesis, including availability of building blocks and starting materials from a wide range of suppliers.
In this Manifold integration, StarDrop users can access a range of functionality. This includes the ability to generate a ‘Fast Synthetic Accessibility Score’ and ‘Estimated Synthetic Accessibility Rating’ for molecules, and to propose synthetic routes based on retrosynthetic analysis and a survey of available building blocks and starting materials.
This integration is available to use with the latest version of StarDrop (Windows and macOS). To find out which version you have installed, start StarDrop and select the Help->About menu.
If you are using an older version of StarDrop, please contact us at support@optibrium.com and we will be happy to help install this script on your StarDrop client.
The first time you use the script you will need to install a new API token. To do this, click on the Custom Scripts > Manifold menu item and select Change Token. Tokens must be obtained directly from PostEra. If you do not already have a token, you can request one by clicking the Request Token button on the Manifold Token dialogue. This will take you to the request form. The token will authenticate you each time you use this script and will be remembered after you have used it the first time.
Please note, to use this script, you must have a Manifold account. Therefore, if you do not have a Manifold account, follow the link at the top of the request form, or click here to set up your Manifold account.
Once the token is set up, you can access all the features of the Manifold integration in the Custom Scripts > Manifold menu, including Fast Scores, Fast Alerts and Retrosynthetic Analyses.
Fast Synthetic Accessibility Score: calculate a score between 0 (good; easy to synthesise) and 1 (bad; difficult to synthesise) for all selected molecules. These scores are based on searching the molecules for structural features.
Fast Synthetic Accessibility Alert: alongside the Fast Synthetic Accessibility Score, you can get a categorical alert with a value of None (no potential synthesis issues identified), Low, Medium or High. For a compound where the alert status is not None, Manifold can provide an image that highlights the substructures that present particular problems for synthesis.
Retrosynthetic Analysis: Manifold conducts a deep search available building blocks, starting materials and potential reactions. This generates a retrosynthetic analysis score between 0 (good; easy to synthesise) and 1 (bad; difficult to synthesise), providing a more detailed view on the synthetic accessibility of your chosen compounds (up to 10 compounds can be searched at once). Follow the “Manifold link” hyperlink in the StarDrop data table to see the relevant page in Manifold, and click on the molecule diagram to generate the full Manifold analysis.
The first time you use the script you will need to install a new API token. To do this, click on the Custom Scripts > Manifold menu item and select Change Token. Tokens must be obtained directly from PostEra. If you do not already have a token, you can request one by clicking the Request Token button on the Manifold Token dialogue. This will take you to the request form. The token will authenticate you each time you use this script and will be remembered after you have used it the first time.
Please note, to use this script, you must have a Manifold account. Therefore, if you do not have a Manifold account, follow the link at the top of the request form, or click here to set up your Manifold account.
Once the token is set up, you can access all the features of the Manifold integration in the Custom Scripts > Manifold menu, including Fast Scores, Fast Alerts and Retrosynthetic Analyses.
Fast Synthetic Accessibility Score: calculate a score between 0 (good; easy to synthesise) and 1 (bad; difficult to synthesise) for all selected molecules. These scores are based on searching the molecules for structural features.
Fast Synthetic Accessibility Alert: alongside the Fast Synthetic Accessibility Score, you can get a categorical alert with a value of None (no potential synthesis issues identified), Low, Medium or High. For a compound where the alert status is not None, Manifold can provide an image that highlights the substructures that present particular problems for synthesis.
Retrosynthetic Analysis: Manifold conducts a deep search available building blocks, starting materials and potential reactions. This generates a retrosynthetic analysis score between 0 (good; easy to synthesise) and 1 (bad; difficult to synthesise), providing a more detailed view on the synthetic accessibility of your chosen compounds (up to 10 compounds can be searched at once). Follow the “Manifold link” hyperlink in the StarDrop data table to see the relevant page in Manifold, and click on the molecule diagram to generate the full Manifold analysis.
The Chemical Information & Computer Applications Group (CICAG) and Biological & Medicinal Chemistry Sector (BMCS) of the Royal Society of Chemistry are once again organising a conference to present the current advances in AI and machine learning in Chemistry.
The joint ISSX/JSSX meeting is for researchers looking to gain a deeper understanding of drug metabolism and pharmacokinetics.
