Preprint: Considering the Impact of ‘Drug-like’ Properties on the Chance of Success This paper was published in Drug Discovery Today 18(13-14), pp. 659-666 (DOI 10.1016/j.drudis.2013.02.008). In the paper we review the strengths and weaknesses of different definitions...
P-gp Transporter Models P-glycoprotein (P-gp) is an ATP driven efflux pump encoded by the MDR1 gene, capable of transporting a wide spectrum of chemical structures as well as different classes of drugs. Active transport by P-gp can represent a serious hurdle for...
Caco-2 Model Permeability across monolayers of the Caco-2 line of human epithelial colorectal adenocarcinoma cells is a common in vitro model used to assess potential of compounds to be absorbed across the human intestine. The apparent permeability (Papp) from the...
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