09 Hit List TriageCDK2 hitsCount vs Series<Custom>CDK2 TriageCDK2 hitsVisualisationCDK2 hits0CDK2 hitseEh#.ID._<Rule> <Rule> <Column></Column> <UserCreated>0</UserCreated> <ValueType>0</ValueType> <Value></Value> <IncrementStart>1</IncrementStart> <IncrementChange>1</IncrementChange> <Temporary>0</Temporary> </Rule> </Rule> muRN);Q pIC50>O<RulesList> <Rule> <Column>pIC50</Column> <UserCreated>1</UserCreated> <ValueType>0</ValueType> <Value></Value> <IncrementStart>1</IncrementStart> <IncrementChange>1</IncrementChange> <Temporary>0</Temporary> <Units>5</Units> <SDType>0</SDType> <SD>0.3</SD> <SDColumn></SDColumn> <RemoveColumn>0</RemoveColumn> <KeepOriginals>0</KeepOriginals> <UseValue>1</UseValue> <Precision>-1</Precision> <FloatingPointDisplay>Default</FloatingPointDisplay> </Rule> </RulesList> xdPD5j .X SMILES<Rule> <Rule> <Column></Column> <UserCreated>0</UserCreated> <RemoveSalts>1</RemoveSalts> <UseFileDiagramCoords>True</UseFileDiagramCoords> <CombineConformers>False</CombineConformers> </Rule> </Rule> . AJ 9.[ Seriesx<<RulesList> <Rule> <Column>Series</Column> <UserCreated>0</UserCreated> <UseDefault>1</UseDefault> <Categories> <Category Index="0" Name="2-aminopyrimidine, 4-aroring"/> <Category Index="1" Name="Imidazo pyrazines"/> <Category Index="2" Name="Amino purines"/> <Category Index="3" Name="2,4-diaminopyrimidines"/> <Category Index="4" Name="Amino quinazoline"/> <Category Index="5" Name="Odds"/> <Category Index="6" Name="amino non-purines"/> <Category Index="7" Name="4- and 4,6-aminopyrimidines"/> <Category Index="8" Name="Aminopyrazines"/> <Category Index="9" Name="Pyrimidinyl quinolones"/> </Categories> </Rule> </RulesList> Xf*Exc". AJ 9.[82-aminopyrimidine, 4-aroring?8eEh#. CHEMBL460086xdPD5j .XCC(C)[N]1C(=NC=C1C2=NC(=NC=C2)NC3=CC=C(C=C3)C(=O)N4CC[C@@H](C4)NC5CC5)CEOSA$b4f7c545-f90b-400d-8b93-5caf14521b1e64C1 5.17234898 -1.533735510C2 4.2212925 -1.842752460C3 4.01338053 -2.820899960N4 3.47814751 -1.173621890C52.5 -1.38153350N62 -0.5155081150C7 2.66913056 0.2276366950C8 3.58267617 -0.1790999470C9 4.44870138 0.3209000530 N10 5.31472683 -0.1790999470 C11 6.18075228 0.3209000530 N12 6.18075228 1.320900080 C13 5.31472683 1.820900080 C14 4.44870138 1.320900080N15 7.04677773 -0.1790999470C16 7.91280317 0.3209000530C17 8.77882862 -0.1790999470C18 9.64485359 0.3209000530C19 9.64485359 1.320900080C20 8.77882862 1.820900080C21 7.91280317 1.320900080C22 10.5108795 1.820900080O23 10.5108795 2.820899960N24 11.3769045 1.320900080C25 12.2904501 1.727636690C26 12.9595804 0.9844918850C27 12.4595804 0.1184664670H28 12.0694017 -0.363364130C29 11.4814329 0.3263781670N30 12.8663177 -0.7950789930C31 13.8608389 -0.899607480C32 14.6698561 -1.487392660 C33 14.7743845 -0.4928708080!C34 2.09326339 -2.295078990"H35 5.36393929 -2.123390670#H36 5.7620039 -1.342144970$H37 4.98075867 -0.9440804720%H38 4.68204212 -2.257613420&H39 3.40692902 -2.691994430'H40 3.88447499 -3.427351470(H41 4.61983204 -2.94980550)H42 2.54022527 0.8340882060*H43 5.31472683 2.440900090+H44 3.91176558 1.630900140,H45 7.04677773 -0.7990999220-H46 8.77882862 -0.7990999220.H47 10.1817894 0.01090011090/H48 8.77882862 2.4409000900H49 7.37586737 1.6309001401H50 12.7920408 2.0920634302H51 11.9804506 2.2645723803H52 13.4611712 0.62006497404H53 13.3744411 1.4452415705H54 10.861433 0.32637819606H55 11.416625 -0.29022541607H56 12.5018902 -1.2966694808H57 13.6386509 -1.4784274109H58 14.3980656 -2.044645070:H59 15.2658386 -1.658287760;H60 15.3928738 -0.4496217970<H61 14.6243925 0.1087125470=H62 1.52686524 -2.042902230>H63 1.84108675 -2.861477140?H64 2.65966153 -2.54725575068             !" # $!%"&#'$(%)&*'+(,)- *. +/,0-1.2/30415263748596:7;8<9=:> ;? <@!=A!>B!?C0H00000000-0000-0000-0000-000000000000muRN);Q@"?33@j7rH>Yt#*. AJ 9.[82-aminopyrimidine, 4-aroring?8eEh#. 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AJ 9.[82-aminopyrimidine, 4-aroring?8eEh#. CHEMBL509881xdPD5j .XjCC(C)[N]1C(=NC=C1C2=NC(=NC=C2F)NC3=CC=C(C=C3)C(N)=O)C{ۇg_rlDӶ]շ3?{＇nwtFfz+|Ն|޷'.L鳯<6wyD>W3#u OSA$107544ff-44d7-4283-9811-71adc665f0c145C1 5.17234898 -1.533735510C2 4.2212925 -1.842752460C3 4.01338053 -2.820899960N4 3.47814751 -1.173621890C52.5 -1.38153350N62 -0.5155081150C7 2.66913056 0.2276366950C8 3.58267617 -0.1790999470C9 4.44870138 0.3209000530 N10 5.31472683 -0.1790999470 C11 6.18075228 0.3209000530 N12 6.18075228 1.320900080 C13 5.31472683 1.820900080 C14 4.44870138 1.320900080 F15 3.58267617 1.820900080N16 7.04677773 -0.1790999470C17 7.91280317 0.3209000530C18 8.77882862 -0.1790999470C19 9.64485359 0.3209000530C20 9.64485359 1.320900080C21 8.77882862 1.820900080C22 7.91280317 1.320900080C23 10.5108795 1.820900080N24 11.3769045 1.320900080O25 10.5108795 2.820899960C26 2.09326339 -2.295078990H27 5.36393929 -2.123390670H28 5.7620039 -1.342144970H29 4.98075867 -0.9440804720H30 4.68204212 -2.257613420H31 3.40692902 -2.691994430H32 3.88447499 -3.427351470 H33 4.61983204 -2.94980550!H34 2.54022527 0.8340882060"H35 5.31472683 2.440900090#H36 7.04677773 -0.7990999220$H37 8.77882862 -0.7990999220%H38 10.1817894 0.01090011090&H39 8.77882862 2.440900090'H40 7.37586737 1.630900140(H41 11.3769045 0.7009000780)H42 11.9138403 1.630900030*H43 1.52686524 -2.042902230+H44 1.84108675 -2.861477140,H45 2.65966153 -2.54725575047              ! "!# "$#%$&%'&(')(*)+*,+-,.0H00000000-0000-0000-0000-000000000000muRN);Q@"?33@NV}I;1]8D. AJ 9.[82-aminopyrimidine, 4-aroring?8eEh#. CHEMBL495696xdPD5j .XbN#CC1=CC=CC(=C1)NC2=NC(=CC=N2)C3=C4C=CC=N[N]4N=C3OSA$9d36dc0e-3942-4aeb-a926-2ea8898adc9935N1 5.87440062 -4.126078130C2 6.54224443 -3.381776330C3 7.21008825 -2.637474780C4 8.18859386 -2.843693490C5 8.85643768 -2.099391940C6 8.54577541 -1.148871540C7 7.56726933 -0.9426527620C8 6.89942598 -1.686954380N9 7.25660706 0.007867566310 C10 6.27810097 0.2140862790 N11 5.9674387 1.164606690 C12 4.98893309 1.370825290 C13 4.32108927 0.6265237330 C14 4.63175154 -0.3239966330N15 5.61025763 -0.5302153230C16 4.67827082 2.321345810C17 3.7320509 2.626077890C18 2.86602545 2.126077890C192 2.626077890C202 3.626077890N21 2.86602545 4.126078130N22 3.7320509 3.626077890N23 4.67827082 3.930810210C24 5.26187944 3.126077890H25 8.38120461 -3.433016060H26 9.46311092 -2.227247710H27 8.95983887 -0.6874045730H28 6.29275227 -1.559098840H29 7.67067003 0.4693345730H30 3.71441555 0.7543793920H31 4.21768856 -0.7854636310H32 2.86602545 1.506077890 H33 1.46306419 2.316077950!H34 1.46306419 3.936077830"H35 5.88187933 3.12607789038              !" #!$"%0H00000000-0000-0000-0000-000000000000muRN);Q@!e`?33@ qK8wx4Ɯ. AJ 9.[82-aminopyrimidine, 4-aroring?8eEh#. 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" #!$"%#&$'%(&)'*0H00000000-0000-0000-0000-000000000000muRN);Q@!e`?33@-1AWWt. AJ 9.[82-aminopyrimidine, 4-aroring?8eEh#. 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"!#"$#% $&%'&(')(*)+*,+-,.-/.0/10213240H00000000-0000-0000-0000-000000000000muRN);Q@!e`?33@I;@tӹ^V. AJ 9.[82-aminopyrimidine, 4-aroring?8eEh#. 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Ơ?33@(ЂKwg?. AJ 9.[82-aminopyrimidine, 4-aroring?8eEh#. 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Ơ?33@#ډHKPiXhE. AJ 9.[82-aminopyrimidine, 4-aroring?8eEh#. CHEMBL478409xdPD5j .X|COCCN[S](=O)(=O)C1=CC=C(NC2=NC=CC(=N2)C3=CN=C(C)[N]3C(C)C)C=C1oϦg_oy״꜎UշW_䋒u6VGK|Uxcn\ۯ|+ib>ӳ} EOSA$c1ec6f4e-acb5-4770-a2e5-ff5c69c6d13556C12 6.673929210O22 5.673929210C3 2.86602545 5.173929210C4 2.86602545 4.173929210N5 3.7320509 3.673929450S6 3.7320509 2.673929450O7 4.7320509 2.673929450O8 2.7320509 2.673929450C9 3.7320509 1.673929330 C10 2.86602545 1.173929330 C11 2.86602545 0.1739293780 C12 3.7320509 -0.3260706070 N13 3.7320509 -1.326070670 C14 4.59807634 -1.826070670N15 5.46410179 -1.326070670C16 6.33012724 -1.826070670C17 6.33012724 -2.826070550C18 5.46410179 -3.326070550N19 4.59807634 -2.826070550C20 5.46410179 -4.326070790C21 4.65508461 -4.913856030N22 4.96410179 -5.864912510C23 5.96410179 -5.864912510C24 6.55188704 -6.673929210N25 6.2731185 -4.913856030C26 7.22417498 -4.604838850C27 7.43208694 -3.626691340C28 7.96731997 -5.273969650C29 4.59807634 0.1739293780C30 4.59807634 1.173929330H31 2.61999989 6.673929210H322 7.29392910 H331.38 6.673929210!H34 3.47660637 5.066267490"H35 3.07807803 5.756538870#H36 2.25544453 4.281590940$H37 2.6539731 3.59131980%H38 4.2689867 3.98392940&H39 2.32908964 1.48392940'H40 2.32908964 -0.1360706240(H41 3.19511509 -1.636070610)H42 6.86706305 -1.51607060*H43 6.86706305 -3.136070490+H44 4.06542969 -4.722265720,H45 6.05029678 -7.03835630-H46 6.91631413 -7.175519470.H47 7.05347729 -6.309502120/H48 6.76342535 -4.1899776500H49 8.03853798 -3.7555968801H50 7.56099224 -3.0202398302H51 6.82563543 -3.4977858103H52 7.55245876 -5.7347192804H53 8.42807007 -5.6888308505H54 8.38218117 -4.8132200206H55 5.13501215 -0.13607062407H56 5.13501215 1.4839294058            ! "!#"$#%$&%' &( ') (*)+*,+-,.-/.0/102132435465768790H00000000-0000-0000-0000-000000000000muRN);Q@! Ơ?33@0)0H00000000-0000-0000-0000-000000000000muRN);Q@! Ơ?33@! +B˃. AJ 9.[82-aminopyrimidine, 4-aroring?8eEh#. CHEMBL478407xdPD5j .X^CC(C)[N]1C(=NC=C1C2=NC(=NC=C2)NC3=CC=C(F)C=C3)C )OSA$b0d21704-73cd-4ba7-aadc-81b6e77e96bc41C1 5.17234898 -1.033735510C2 4.2212925 -1.342752460C3 4.01338053 -2.320899960N4 3.47814751 -0.6736218330C52.5 -0.8815335630N62 -0.01550813110C7 2.66913056 0.7276366950C8 3.58267617 0.3209000530C9 4.44870138 0.8209000230 N10 5.31472683 0.3209000530 C11 6.18075228 0.8209000230 N12 6.18075228 1.820900080 C13 5.31472683 2.320899960 C14 4.44870138 1.820900080N15 7.04677773 0.3209000530C16 7.91280317 0.8209000230C17 8.77882862 0.3209000530C18 9.64485359 0.8209000230C19 9.64485359 1.820900080 F20 10.5108795 2.320899960C21 8.77882862 2.320899960C22 7.91280317 1.820900080C23 2.09326339 -1.795078990H24 5.36393929 -1.623390560H25 5.7620039 -0.8421450260H26 4.98075867 -0.4440804720H27 4.68204212 -1.757613540H28 3.40692902 -2.191994430H29 3.88447499 -2.927351470H30 4.61983204 -2.44980550H31 2.54022527 1.334088210H32 5.31472683 2.940899850 H33 3.91176558 2.130900140!H34 7.04677773 -0.2990999520"H35 8.77882862 -0.2990999520#H36 10.1817894 0.510900080$H37 8.77882862 2.940899850%H38 7.37586737 2.130900140&H39 1.52686524 -1.542902230'H40 1.84108663 -2.361477140(H41 2.65966153 -2.04725575043             ! "!#"$#%$&%'&(')(*0H00000000-0000-0000-0000-000000000000muRN);Q@! Ơ?33@vB+$. AJ 9.[82-aminopyrimidine, 4-aroring?8eEh#. CHEMBL72672xdPD5j .X\N(C1=CC=CC=C1)C2=NC(=CC=N2)C3=CN=C4C=CC=C[N]34OSA$e93e3594-5a2b-49a5-8a75-f7bdf19d687835N1 3.96390796 1.171407580C2 4.27457047 2.121927980C3 5.25307608 2.32814670C4 5.56373835 3.278666970C54.895895 4.022968770C6 3.91738892 3.816749810C7 3.60672665 2.866229530C8 4.63175154 0.4271059930N9 4.32108927 -0.5234143730 C10 4.98893309 -1.267715930 C11 5.9674387 -1.061497330 C12 6.27810097 -0.1109769270 N13 5.61025763 0.6333246830 C14 4.67827082 -2.218236450C15 5.26187944 -3.022968530N16 4.67827082 -3.827700850C17 3.7320509 -3.522968530C18 2.86602545 -4.022968770C192 -3.522968530C202 -2.522968530C21 2.86602545 -2.022968530N22 3.7320509 -2.522968530H23 3.35723424 1.043552040H24 5.66713905 1.866679670H25 6.17041206 3.406522510H26 5.08850574 4.612291340H27 3.50332594 4.278216840H28 3.00005293 2.738373760H29 6.38150167 -1.522964360H30 6.88477468 0.01687863660H31 5.88187933 -3.022968530H32 2.86602545 -4.642968650 H33 1.46306419 -3.832968470!H34 1.46306419 -2.212968590"H35 2.86602545 -1.40296853038                !" #!$"%0H00000000-0000-0000-0000-000000000000muRN);Q@! Ơ?33@-jŒLWVQz. AJ 9.[82-aminopyrimidine, 4-aroring?8eEh#. CHEMBL73038xdPD5j .XCOCCN[S](=O)(=O)C1=CC=C(NC2=NC(=CC=N2)C3=CN=C4C=CC(=C[N]34)Br)C=C1yݮw}bj}Ϟշ_z⫒~ww/O! cckcG|IcMkso|Hϧ|(lZ[ooų] OSA$7aaee9f4-fff0-4d90-89bf-5f10dfcde1b250C1 5.66888237 6.668311120O2 5.3582201 5.71779060C3 6.02606344 4.973488810C4 5.71540117 4.022968770N5 6.38324499 3.278666970S6 6.07258272 2.32814670O7 7.02310276 2.017484430O8 5.12206221 2.638808970C9 5.76192045 1.37762630 C10 4.78341436 1.171407580 C11 4.47275209 0.2208872590 C12 5.14059591 -0.5234143730 N13 4.82993317 -1.473934650 C14 5.49777699 -2.218236450N15 5.18711472 -3.168756720C16 5.85495853 -3.913058280C17 6.83346415 -3.706839560C18 7.14412642 -2.756319280N19 6.47628307 -2.012017730C20 5.54429579 -4.86357880C21 6.12790489 -5.668311120N22 5.54429579 -6.473043440C23 4.59807634 -6.168311120C24 3.7320509 -6.668311120C25 2.86602545 -6.168311120C26 2.86602545 -5.168311120C27 3.7320509 -4.668311120N28 4.59807634 -5.168311120#Br292 -4.668311120C30 6.11910152 -0.3171956540C31 6.42976379 0.6333246830H32 6.25820494 6.475700380 H33 5.86149311 7.257633690!H34 5.0795598 6.860921860"H35 6.5729866 4.681469440#H36 6.40861845 5.461394310$H37 5.16847801 4.314988140%H38 5.33284616 3.535063270&H39 6.98991871 3.406522510'H40 4.36935139 1.632874610(H41 3.86607838 0.09303159270)H42 4.22325993 -1.601790310*H43 7.24752712 -4.168306350+H44 7.75080013 -2.628463750,H45 6.74790478 -5.668311120-H46 3.7320509 -7.2883110.H47 2.32908964 -6.478311060/H48 3.7320509 -4.0483112300H49 6.5331645 -0.77866262201H50 7.03643751 0.761180222053            !" #!$"%#&$'%(&) '* (+ ),*-+.,/-0.1/203140H00000000-0000-0000-0000-000000000000muRN);Q@! Ơ?33@S-A\W=ڻ7. AJ 9.[82-aminopyrimidine, 4-aroring?8eEh#. CHEMBL72464xdPD5j .X^CC1=C([N]2C=CC=CC2=N1)C3=NC(=NC=C3)NC4=CC=CC=C4OSA$8ca8d70f-e0cb-490d-8757-3da311692ed938C1 6.26187944 -3.022968530C2 5.26187944 -3.022968530C3 4.67827082 -2.218236450N4 3.7320509 -2.522968530C5 2.86602545 -2.022968530C62 -2.522968530C72 -3.522968530C8 2.86602545 -4.022968770C9 3.7320509 -3.522968530 N10 4.67827082 -3.827700850 C11 4.98893309 -1.267715930 N12 4.32108927 -0.5234143730 C13 4.63175154 0.4271059930 N14 5.61025763 0.6333246830C15 6.27810097 -0.1109769270C16 5.9674387 -1.061497330N17 3.96390796 1.171407580C18 4.27457047 2.121927980C19 5.25307608 2.32814670C20 5.56373835 3.278666970C214.895895 4.022968770C22 3.91738892 3.816749810C23 3.60672665 2.866229530H24 6.26187944 -3.642968420H25 6.88187933 -3.022968530H26 6.26187944 -2.402968650H27 2.86602545 -1.402968530H28 1.46306419 -2.212968590H29 1.46306419 -3.832968470H30 2.86602545 -4.642968650H31 6.88477468 0.01687863660H32 6.38150167 -1.522964360 H33 3.35723424 1.043552040!H34 5.66713905 1.866679670"H35 6.17041206 3.406522510#H36 5.08850574 4.612291340$H37 3.50332594 4.278216840%H38 3.00005293 2.73837376041              !" #!$"%#&$'%(0H00000000-0000-0000-0000-000000000000muRN);Q@! Ơ?33@ ?|Mzw. AJ 9.[82-aminopyrimidine, 4-aroring?8eEh#. CHEMBL453655xdPD5j .XnCNC(=O)C1=CC=C(NC2=NC=CC(=N2)C3=CN=C(COC)[N]3C(C)C)C=C1 OSA$ab2d20ff-2266-4184-b2cc-0117ce5397d752C1 13.5509253 2.067026380N2 12.6849003 1.56702650C3 11.8188744 2.067026380O4 11.8188744 3.067026380C5 10.9528494 1.56702650C6 10.0868235 2.067026380C7 9.22079849 1.56702650C8 9.22079849 0.5670264960N9 8.35477257 0.0670264810 C10 7.4887476 0.5670264960 N11 7.4887476 1.56702650 C12 6.62272215 2.067026380 C13 5.7566967 1.56702650 C14 5.7566967 0.5670264960N15 6.62272215 0.0670264810C16 4.89067125 0.0670264810C17 3.97712588 0.4737631380N18 3.30799508 -0.2693817020C19 3.80799508 -1.135407090C20 3.40125847 -2.048952580O21 2.40673661 -2.153481010C222 -3.067026380N23 4.78614283 -0.927495420C24 5.52928782 -1.596626040C25 6.4803443 -1.287608980C26 5.32137585 -2.574773550C27 10.0868235 0.0670264810C28 10.9528494 0.5670264960H29 13.8609257 1.530090690H30 14.0878611 2.377026320H31 13.2409248 2.603962180H32 12.6849003 0.9470264910 H33 10.0868235 2.687026260!H34 8.68386269 1.877026440"H35 8.35477257 -0.5529735090#H36 6.62272215 2.687026260$H37 5.21976089 1.877026560%H38 3.84822059 1.080214620&H39 3.35800934 -2.667442320'H40 4.00284195 -2.198944090(H41 1.43360186 -2.814849620)H42 1.74782324 -3.633424520*H43 2.56639814 -3.319203140+H44 5.99003744 -2.011487010,H45 6.67193508 -1.877264020-H46 7.06999922 -1.096018430.H47 6.28875351 -0.6979539390/H48 4.71492434 -2.4458680200H49 5.19247055 -3.1812250601H50 5.92782736 -2.7036790802H51 10.0868235 -0.55297350903H52 11.4897852 0.257026434054              ! "!#"$ #% $&%'&(')(*)+*,+-,.-/.0/1021324350H00000000-0000-0000-0000-000000000000muRN);Q@! Ơ?33@еbE[r. AJ 9.[82-aminopyrimidine, 4-aroring?8eEh#. CHEMBL308853xdPD5j .XvCN[S](=O)(=O)C1=CC=C(NC2=NC(=CC=N2)C3=CN=C4C=CC=C[N]34)C=C1H00000000-0000-0000-0000-000000000000muRN);Q@! Ơ?33@-\uA2( I k. AJ 9.[82-aminopyrimidine, 4-aroring?8eEh#. CHEMBL478408xdPD5j .X`CC(C)[N]1C(=NC=C1C2=NC(=NC=C2)NC3=CC=C(Cl)C=C3)CH00000000-0000-0000-0000-000000000000muRN);Q@! Ơ?33@!%6-Ou06>N. AJ 9.[82-aminopyrimidine, 4-aroring?8eEh#. CHEMBL70808xdPD5j .XCOCCN[S](=O)(=O)C1=CC=C(NC2=NC(=C(Br)C=N2)C3=CN=C4C=CC=C[N]34)C=C1H00000000-0000-0000-0000-000000000000muRN);Q@! Ơ?33@@ˆÿ. AJ 9.[82-aminopyrimidine, 4-aroring?8eEh#. CHEMBL73243xdPD5j .X~COCCCN[S](=O)(=O)C1=CC=C(NC2=NC(=CC=N2)C3=CN=C4C=CC=C[N]34)C=C1H00000000-0000-0000-0000-000000000000muRN);Q@ Ơ?33@PLs. AJ 9.[82-aminopyrimidine, 4-aroring?8eEh#. CHEMBL468963xdPD5j .XCN1CCN(CC1)C2=C(C=C(NC3=NC(=CC=N3)C4=C5C=CC=N[N]5N=C4)C=C2)C(F)(F)FH00000000-0000-0000-0000-000000000000muRN);Q@ Ơ?33@Z,>@8{w֙. AJ 9.[82-aminopyrimidine, 4-aroring?8eEh#. CHEMBL295136xdPD5j .XPCC1=NC(=C(S1)C2=NC(=NC=C2)NC3=CC=CC=C3)CH00000000-0000-0000-0000-000000000000muRN);Q@ ?33@h l yMx. AJ 9.[82-aminopyrimidine, 4-aroring?8eEh#. CHEMBL72509xdPD5j .X`ClC1=CC=CC(=C1)NC2=NC=CC(=N2)C3=CN=C4C=CC=C[N]34H00000000-0000-0000-0000-000000000000muRN);Q@ ?33@\GEBU}. AJ 9.[82-aminopyrimidine, 4-aroring?8eEh#. CHEMBL70824xdPD5j .XCN(C)CCCN(C)[S](=O)(=O)C1=CC=C(NC2=NC(=CC=N2)C3=CN=C4C=CC=C[N]34)C=C1׮w]ob}j}ſ_x䫓^'wz_!Bcc[kbC|IaMki1)|ί|(VlZ[o/ѳ] )OSA$08edf794-c075-4267-a4f6-9f1923a1f8e960 12.8687716 -0.9955336450 11.8891153 -1.196214680 11.573082 -2.144962790 11.2254925 -0.4481475350 10.2458363 -0.6488283870 9.5822134 0.0992387980 8.60255718 -0.1014421580 8.28652382 -1.050190210 7.93893385 0.6466249820 7.19086647 -0.0169979930 8.68700123 1.310248020 7.27531099 1.394692180 6.29115963 1.190063360 5.62748003 1.938121910 5.93796539 2.888732910 5.27105618 3.633872030 4.29229212 3.428881410 3.98163462 2.472890140 3.00285006 2.267845870 2.33157039 3.009092090 2.64222789 3.965083360 3.62416482 4.179828170 2.69379997 1.316800120 3.28579974 0.5022000670 2.69379973 -0.3125998970 1.73599982-0.001299918630 0.867999971 -0.4979000090000-1.09945098e-07 1.005800720 0.868000031 1.51370060 1.73599994 1.005800370 6.92211676 3.093362090 7.59578276 2.347379680! 5.50494719 4.34646940"0#0$0%0&0'0(0)0*0+0,0-0.0/000102030405060708090:0;063            !" #!$"%#&$'%(&)'*(+),*-+.,/-0.1/2031 42 5364758697:8;9<:=; >00H00000000-0000-0000-0000-000000000000muRN);Q@ ?33@_یNo7GD. AJ 9.[82-aminopyrimidine, 4-aroring?8eEh#. CHEMBL72548xdPD5j .XCN(C)CCN[S](=O)(=O)C1=CC=C(NC2=NC(=CC=N2)C3=CN=C4C=CC=C[N]34)C=C1H00000000-0000-0000-0000-000000000000muRN);Q@ ?33@L=¤. AJ 9.[82-aminopyrimidine, 4-aroring?8eEh#. CHEMBL520353xdPD5j .X~CC(C)OCCCN[S](=O)(=O)C1=CC=C(NC2=NC=CC(=N2)C3=CN=C(C)[N]3C)C=C1H00000000-0000-0000-0000-000000000000muRN);Q@ q?33@C$TN;DžH. AJ 9.[82-aminopyrimidine, 4-aroring?8eEh#. CHEMBL434217xdPD5j .XxCC1=N[N]2N=C(C3=CC=CC=C3)C(=C2C=C1)C4=NC(=NC=C4)NC5=CC=CC=C5H00000000-0000-0000-0000-000000000000muRN);Q@ O\ ?33@ Pp@vA. AJ 9.[82-aminopyrimidine, 4-aroring?8eEh#. CHEMBL455467xdPD5j .X|CC(C)[N]1C(=NC=C1C2=NC(=NC=C2)NC3=CC=C(C=C3)C(=O)N4CCN(C)CC4)CH00000000-0000-0000-0000-000000000000muRN);Q@ @?33@FK1+G]f:B. AJ 9.[82-aminopyrimidine, 4-aroring?8eEh#. CHEMBL508739xdPD5j .X|CC(C)[N]1C(=NC=C1C2=C(F)C=NC(=N2)NC3=CC(=C(C=C3)C(=O)N(C)C)C)CH00000000-0000-0000-0000-000000000000muRN);Q@ @?33@)JJ>cHs. AJ 9.[82-aminopyrimidine, 4-aroring?8eEh#. CHEMBL362109xdPD5j .XFC(F)(F)C1=CC=CC(=C1)NC2=NC(=CC=N2)C3=C4C=CC=N[N]4N=C3C5=CC=C(Cl)C=C5{I嬽`}{y;qWϲmCfWp7kKE8*-۶:/j;|%/Ͻ# jN8rĨNvfN‹I_'OSA$14503b44-0d11-44e7-9310-604f95af855f47 8.82737923 5.160626890 7.84984207 4.949863430  8.06060505 3.972326280  7.63907862 5.927400590 6.87230492 4.739100460 6.19972038 5.486132620 5.2221427 5.27540970 4.91032457 4.325234890 5.58290911 3.578202720 6.56731224 3.781345610 5.27105474 2.628072980 4.29229116 2.423081870 3.98163414 1.467090490 3.00284958 1.262045860 2.33156991 2.003292080 2.64222693 2.959283350 3.62416363 3.17402840 2.69379973 0.3110000190 1.73599994-2.16547988e-080 0.8679999710.50790000-2.44626335e-07 -1.005800130 0.867999792 -1.503700020 1.7359997 -1.007099990 2.69379973 -1.318399910 3.28579974 -0.5035998820 4.2857995 -0.503541470 4.78577852 0.3684955240 5.78580952 0.3686019480 6.29093552 -0.4944798050 7.2909255 -0.4900200370 5.79095697 -1.366516710 4.78585243 -1.375471830! 5.7712369 2.069218870"0#0$0%0&0'0(0)0*0+0,0-0.051              !"# $ !%"&#'$(% )&*'+(,)-*.+/,0-1. 200H00000000-0000-0000-0000-000000000000muRN);Q@ ?33@XqDie;. AJ 9.[82-aminopyrimidine, 4-aroring?8eEh#. CHEMBL186656xdPD5j .X~CC1=C(NC2=NC(=CC=N2)C3=CN=CC=C3)C=C(NC(=O)NC4=CC(=CC=C4)Cl)C=C1H00000000-0000-0000-0000-000000000000muRN);Q@ ?33@\Ch4ǟ. AJ 9.[82-aminopyrimidine, 4-aroring?8eEh#. CHEMBL187984xdPD5j .XCC1=C(NC2=NC(=CC=N2)C3=CN=CC=C3)C=C(NC(=O)NC4=C5C=N[NH]C5=CC=C4)C=C1H00000000-0000-0000-0000-000000000000muRN);Q@ ?33@q=F(r. AJ 9.[82-aminopyrimidine, 4-aroring?8eEh#. CHEMBL453895xdPD5j .XCC(C)[N]1C(=NC=C1C2=NC(=NC=C2)NC3=CC(=C(C=C3)C(=O)NC4CCN(C)CC4)F)CH00000000-0000-0000-0000-000000000000muRN);Q@ ?33@,D r *$p. AJ 9.[82-aminopyrimidine, 4-aroring?8eEh#. CHEMBL309573xdPD5j .X|COCCN[S](=O)(=O)C1=CC=C(NC2=NC(=CC=N2)C3=CN=C4C=CC=C[N]34)C=C1H00000000-0000-0000-0000-000000000000muRN);Q@?33@WC@6xoBV. AJ 9.[82-aminopyrimidine, 4-aroring?8eEh#. CHEMBL451462xdPD5j .X~CC(C)[N]1C(=NC=C1C2=NC(=NC=C2F)NC3=CC=C(C=C3)C(=O)N4CCN(C)CC4)CH00000000-0000-0000-0000-000000000000muRN);Q@@?33@8bf@|. AJ 9.[82-aminopyrimidine, 4-aroring?8eEh#. CHEMBL457979xdPD5j .XCC(C)[N]1C(=NC=C1C2=NC(=NC=C2)NC3=CC=C(C=C3)[S](=O)(=O)CC4=CC=CC=C4)CH00000000-0000-0000-0000-000000000000muRN);Q@M?33@ y8H i. AJ 9.[82-aminopyrimidine, 4-aroring?8eEh#. CHEMBL359556xdPD5j .X\N(C1=CC=CC=C1)C2=NC(=CC=N2)C3=C4C=CC=N[N]4N=C3kI嬭 ]{dyͮaOUϲ lCFQp7kKD W2!ږ:.jh!9# hNr}RL vFN‹OI#u=OSA$c8e0a228-2493-4810-b672-7cc1598ed77934 5.27105474 2.628072980 5.93796396 1.882934330 6.92120552 2.09189320 7.58817148 1.346763130 7.28187323 0.3947947030 6.29863214 0.1858358980 5.62168884 0.9288455250 4.29229116 2.423081870 3.98163414 1.467090490 3.00284958 1.262045860 2.33156991 2.003292080 2.64222693 2.959283350 3.62416363 3.17402840 2.69379973 0.3110000190 1.73599994-2.16547988e-080 0.8679999710.50790000-2.44626335e-07 -1.005800130 0.867999792 -1.503700020 1.7359997 -1.007099990 2.69379973 -1.318399910 3.28579974 -0.5035998820 5.50494528 3.340670350000000000 0!037                !" #!$00H00000000-0000-0000-0000-000000000000muRN);Q@&?33@늗IE+iN<. AJ 9.[82-aminopyrimidine, 4-aroring?8eEh#. CHEMBL102926xdPD5j .XzCN(C)CC(O)COC1=CC=C(NC2=NC=CC(=N2)C3=C(C)N=C4C=CC=C[N]34)C=C1H00000000-0000-0000-0000-000000000000muRN);Q@@?33@ LOq". AJ 9.[82-aminopyrimidine, 4-aroring?8eEh#. CHEMBL455468xdPD5j .X~CC(C)[N]1C(=NC=C1C2=NC(=NC=C2)NC3=CC=C(C=C3)C(=O)NC4CCN(C)CC4)CH00000000-0000-0000-0000-000000000000muRN);Q@^@?33@9T~J&Nwzۨ. AJ 9.[82-aminopyrimidine, 4-aroring?8eEh#. CHEMBL488256xdPD5j .XnCNC(=O)C1=CC=C(NC2=NC=CC(=N2)C3=CN=C(C)[N]3C4CCCC4)C=C1H00000000-0000-0000-0000-000000000000muRN);Q@ @?33@'B2fřD #,. AJ 9.[82-aminopyrimidine, 4-aroring?8eEh#. CHEMBL296468xdPD5j .XZCC1=CC(=CC(=C1)C)NC2=NC(=CC=N2)[N]3C=CN=C3C#NH00000000-0000-0000-0000-000000000000muRN);Q@Y?33@rIeZ9q. AJ 9.[82-aminopyrimidine, 4-aroring?8eEh#. CHEMBL419753xdPD5j .XCOC1=C(OC)C(=CC(=C1)NC2=NC=CC(=N2)C3=CN=C(C=C3)N4CCN[C@H](C4)C(C)C)OCH00000000-0000-0000-0000-000000000000muRN);Q@49`?33@WKp]3(. AJ 9.[82-aminopyrimidine, 4-aroring?8eEh#. CHEMBL513354xdPD5j .XlCCN(CC)CC1=CC(=CC=C1)NC2=NC(=CC=N2)C3=C4C=CC=N[N]4N=C3Y嬽 }{yͮoWoSVWvKE9JWreڶ;:>k n=#$hN(~}SFN_I#uOSA$c99cd643-490c-41b7-9a7d-17cd5d90759951 10.8697519 0.2373099330 10.2072506 0.9863706230 9.22729397 0.7871580720 8.90983868 -0.1611152290 9.57234001 -0.9101760980 8.56479263 1.536218880 7.58483601 1.337006450 6.92115068 2.091881990 5.93796396 1.882934330 5.62167215 0.9287921190 6.28856707 0.1835985480 7.2685442 0.3828647430 5.27105474 2.628072980 4.29229116 2.423081870 3.98163414 1.467090490 3.00284958 1.262045860 2.33156991 2.003292080 2.64222693 2.959283350 3.62416363 3.17402840 2.69379973 0.3110000190 1.73599994-2.16547988e-080 0.8679999710.50790000-2.44626335e-07 -1.005800130 0.867999792 -1.503700020 1.7359997 -1.007099990 2.69379973 -1.318399910 3.28579974 -0.5035998820 5.50494528 3.340670350000 0!0"0#0$0%0&0'0(0)0*0+0,0-0.0/000102054             !" #!$"%#&$'%(&)'*(+),* -+ ., /-0.1/203142500H00000000-0000-0000-0000-000000000000muRN);Q@49`?33@1RgxE'9.. AJ 9.[82-aminopyrimidine, 4-aroring?8eEh#. CHEMBL186342xdPD5j .XvCOC1=N[N]2N=CC(=C2C=C1)C3=NC(=NC=C3)NC4=CC=C(C=C4)[N](=O)=OH00000000-0000-0000-0000-000000000000muRN);Q@ =?33@4RMH׈$. AJ 9.[82-aminopyrimidine, 4-aroring?8eEh#. CHEMBL453651xdPD5j .XpCNC(=O)C1=CC=C(NC2=NC=C(F)C(=N2)C3=CN=C(C)[N]3C(C)C)C=C1H00000000-0000-0000-0000-000000000000muRN);Q@?33@kgk @k. AJ 9.[82-aminopyrimidine, 4-aroring?8eEh#. CHEMBL324577xdPD5j .XtCOC1=C(OC)C(=CC(=C1)NC2=NC(=CC=N2)C3=CN=C(C=C3)N4CCOCC4)OCH00000000-0000-0000-0000-000000000000muRN);Q@$?33@.,"JC'#پ. AJ 9.[82-aminopyrimidine, 4-aroring?8eEh#. CHEMBL187752xdPD5j .XrOC1=N[N]2N=CC(=C2C=C1)C3=CC=NC(=N3)NC4=CC(=CC=C4)C(F)(F)FH00000000-0000-0000-0000-000000000000muRN);Q@C?33@gQ{A #%. AJ 9.[82-aminopyrimidine, 4-aroring?8eEh#. CHEMBL182498xdPD5j .XCC1=N[N]2N=C(C3=CC=C(F)C=C3)C(=C2C=C1)C4=NC(=NC=C4)NC5=CC(=CC=C5)C(F)(F)FH00000000-0000-0000-0000-000000000000muRN);Q@gl?33@fKjW BO. AJ 9.[82-aminopyrimidine, 4-aroring?8eEh#. CHEMBL73189xdPD5j .XfCC1=C([N]2C=CC=CC2=N1)C3=NC(=NC=C3)NC4=CC(=CC=C4)ClH00000000-0000-0000-0000-000000000000muRN);Q@KƠ?33@;"ZK He. AJ 9.[82-aminopyrimidine, 4-aroring?8eEh#. CHEMBL495754xdPD5j .XzCCN(CC)CCNC(=O)C1=CC(=CC=C1)NC2=NC(=CC=N2)C3=C4C=CC=N[N]4N=C3H00000000-0000-0000-0000-000000000000muRN);Q@?33@0gV)@l!My. AJ 9.[82-aminopyrimidine, 4-aroring?8eEh#. CHEMBL72461xdPD5j .XCOCCN[S](=O)(=O)C1=CC=C(NC2=NC(=C(Cl)C=N2)C3=CN=C4C=CC=C[N]34)C=C1H00000000-0000-0000-0000-000000000000muRN);Q@E?33@@;L+l. AJ 9.[82-aminopyrimidine, 4-aroring?8eEh#. CHEMBL186510xdPD5j .XzFC1=CC(=CC(=C1)NC2=NC=CC(=N2)C3=C4C=CC=N[N]4N=C3C5=CC=CC=C5)FH00000000-0000-0000-0000-000000000000muRN);Q@N ?33@(h$(K zMR.. AJ 9.[82-aminopyrimidine, 4-aroring?8eEh#. CHEMBL380331xdPD5j .XbBrC1=C(NC2=NC(=CC=N2)C3=C[NH]C4=NC=CC=C34)C=CC=C1H00000000-0000-0000-0000-000000000000muRN);Q@F?33@'r6CD$ֺ. AJ 9.[82-aminopyrimidine, 4-aroring?8eEh#.CHEMBL1081119xdPD5j .X^CC1=CC=C(NC2=NC(=CC=N2)C3=CN=C4C=CC=CC4=C3)C=C1H00000000-0000-0000-0000-000000000000muRN);Q@?33@ @Ik. AJ 9.[82-aminopyrimidine, 4-aroring?8eEh#. CHEMBL359951xdPD5j .XfCC(C)C1=CC=C(NC2=NC(=CC=N2)C3=C4C=CC=N[N]4N=C3)C=C1H00000000-0000-0000-0000-000000000000muRN);Q@cT?33@z M共Y . AJ 9.[82-aminopyrimidine, 4-aroring?8eEh#. CHEMBL186201xdPD5j .XFC1=CC=C(C=C1)C2=N[N]3N=CC=CC3=C2C4=NC(=NC=C4)NC5=CC(=C(F)C=C5)FH00000000-0000-0000-0000-000000000000muRN);Q@F?33@u2M׿ =. AJ 9.[82-aminopyrimidine, 4-aroring?8eEh#. CHEMBL182260xdPD5j .XCC1=N[N]2N=C(C3=CC=C(F)C=C3)C(=C2C=C1)C4=NC(=NC=C4)NC5=CC(=C(F)C=C5)FH00000000-0000-0000-0000-000000000000muRN);Q@ @?33@Jp@Cu. AJ 9.[82-aminopyrimidine, 4-aroring?8eEh#. CHEMBL73645xdPD5j .XfCC1=C([N]2C=CC=CC2=N1)C3=NC(=NC=C3)NC4=CC=C(Cl)C=C46Iլus_smali񼟆է:>y໒񽯗F&[iK] bi{kB iiɾ_o3 nx\^lZپ{L/A3`uOSA$3d15a5ef-17f4-47f8-8e58-da96766f7c1138 4.2857995 -0.503541470 3.28579974 -0.5035998820 2.69379973 0.3110000190 1.73599994-2.16547988e-080 0.8679999710.50790000-2.44626335e-07 -1.005800130 0.867999792 -1.503700020 1.7359997 -1.007099990 2.69379973 -1.318399910 3.00284958 1.262045860 3.98163462 1.467090490 4.29229116 2.423081870 3.62416339 3.17402840 2.6422267 2.959283110 2.33156967 2.003291850 5.27105522 2.628072980 5.58290958 3.578202720 4.91032505 4.325235840 5.22214365 5.275410180 6.19972181 5.486132140 6.50739145 6.437625410 6.87230587 4.73909950 6.56731224 3.781344890 5.77123737 2.0692188700000000 0!0"0#0$0%041              !" #!$"%#&$'%(00H00000000-0000-0000-0000-000000000000muRN);Q@?33@oJ[Kkd+. AJ 9.[82-aminopyrimidine, 4-aroring?8eEh#. CHEMBL233491xdPD5j .XdN#CC1=CN=C(NC2=CC=C(CCN3CCCC3)C=C2)N=C1C4=CC=CC=C4H00000000-0000-0000-0000-000000000000muRN);Q@?33@cr0I6Gfs. AJ 9.[82-aminopyrimidine, 4-aroring?8eEh#. CHEMBL279590xdPD5j .XZCOC1=CC=C(NC2=NC(=C(C=N2)C#N)C3=CC=CC=C3)C=C1H00000000-0000-0000-0000-000000000000muRN);Q@Q?33@`hBEseٺ3<. AJ 9.[82-aminopyrimidine, 4-aroring?8eEh#. CHEMBL74680xdPD5j .X`ClC1=CC=CC(=C1)NC2=NC=CC(=N2)[N]3C=NC4=C3C=CC=C4H00000000-0000-0000-0000-000000000000muRN);Q@?33@ϳHhIvb. AJ 9.[82-aminopyrimidine, 4-aroring?8eEh#. CHEMBL233489xdPD5j .XbN#CC1=CN=C(NC2=CC=C(CN3CCCC3)C=C2)N=C1C4=CC=CC=C4H00000000-0000-0000-0000-000000000000muRN);Q@49`?33@F7M u՜?. AJ 9.[82-aminopyrimidine, 4-aroring?8eEh#. CHEMBL292021xdPD5j .XfN(C1=CC=CC(=C1)[N]2C=CN=C2)C3=NC(=CC=N3)C4=CN=CC=C4H00000000-0000-0000-0000-000000000000muRN);Q@?33@)Nѿ@t4*U. AJ 9.[82-aminopyrimidine, 4-aroring?8eEh#. CHEMBL370237xdPD5j .XnNCCNC(=O)C1=CC=C(NC2=NC=CC(=N2)C3=CC4=C(S3)C=CC=C4)C=C1H00000000-0000-0000-0000-000000000000muRN);Q@'?33@и"1LH+/. AJ 9.[82-aminopyrimidine, 4-aroring?8eEh#. CHEMBL296682xdPD5j .XZCCNC1=NC(=C(S1)C2=NC(=NC=C2)NC3=CC(=CC=C3)O)CH00000000-0000-0000-0000-000000000000muRN);Q@@?33@^=-F΢(&. AJ 9.[82-aminopyrimidine, 4-aroring?8eEh#. CHEMBL113544xdPD5j .XCOCCN=NNC1=CC=C(C=C1)C(=O)NC2=CC(=CC=C2)NC3=NC(=CC=N3)C4=CN=CC=C4H00000000-0000-0000-0000-000000000000muRN);Q@E?33@moLHȗ ^. AJ 9.[82-aminopyrimidine, 4-aroring?8eEh#. CHEMBL189512xdPD5j .XjC1OC2=C(O1)C=C(NC3=NC=CC(=N3)C4=C5C=CC=N[N]5N=C4)C=C2H00000000-0000-0000-0000-000000000000muRN);Q@?33@ϦD_3A. AJ 9.[82-aminopyrimidine, 4-aroring?8eEh#. CHEMBL326843xdPD5j .XzCC1=C(NC2=NC(=CC=N2)C3=CN=CC=C3)C=C(NC(=O)C4=CC=C(N)C=C4)C=C1H00000000-0000-0000-0000-000000000000muRN);Q@?33@Q# K [. AJ 9.[82-aminopyrimidine, 4-aroring?8eEh#. CHEMBL189732xdPD5j .XFC(F)(F)C1=CC=C(C=C1)C2=N[N]3N=CC=CC3=C2C4=CC=NC(=N4)NC5=CC=CC=C5kI嬽 ]{d{ͮqoUϲmCnSp7kKD8 w1ڶ:.jh!=# jNrLvfNËOI_'uOSA$39ffb261-e21a-4682-835f-82b9ed2619dd47 8.29093742 0.4938075840 7.29094696 0.4981507960  7.28660393 -0.5018398760  7.29528999 1.498141410 6.2909565 0.5024940970 5.78714418 -0.367333740 4.78712225 -0.363038510 4.28579998 0.5022583010 4.78961229 1.372086410 5.7947464 1.376617190 3.28579974 0.5022000670 2.69379973 -0.3125998970 1.73599982-0.001299918630 0.867999971 -0.4979000090000-1.09945098e-07 1.005800720 0.868000031 1.51370060 1.73599994 1.005800370 2.69379997 1.316800120 3.00285006 2.267845870 2.33157039 3.009092090 2.64222789 3.965083360 3.62416482 4.179828170 4.29229212 3.428881410 3.98163462 2.472890140 5.27105618 3.633872030 5.58291101 4.584001540 4.91032648 5.331034180 5.22214556 6.281208520 6.19972372 6.491930480 6.87230778 5.744897840 6.56731367 4.787143230 5.77123785 3.075017690!0"0#0$0%0&0'0(0)0*0+0,0-0.051              !"# $!%"&#'$ (%)&*'+(,)-*.+/,0-1.200H00000000-0000-0000-0000-000000000000muRN);Q@49`?33@JOD. AJ 9.[82-aminopyrimidine, 4-aroring?8eEh#. CHEMBL189543xdPD5j .X~CC1=N[N]2N=C(C3=CC=C(F)C=C3)C(=C2C=C1)C4=NC(=NC=C4)NC5=CC=CC=C5H00000000-0000-0000-0000-000000000000muRN);Q@49`?33@>$@y3B.. AJ 9.[82-aminopyrimidine, 4-aroring?8eEh#. CHEMBL183200xdPD5j .X|CC1=C(C(=C([NH]1)C#N)C)C2=CC=NC(=N2)NC3=CC(=C(C)C=C3)[N](=O)=OH00000000-0000-0000-0000-000000000000muRN);Q@49`?33@7BΡ)or. AJ 9.[82-aminopyrimidine, 4-aroring?8eEh#. CHEMBL189317xdPD5j .XFC1=CC=C(C=C1)C2=N[N]3N=CC=CC3=C2C4=NC(=NC=C4)NC5=CC(=C(Cl)C=C5)C(F)(F)FH00000000-0000-0000-0000-000000000000muRN);Q@49`?33@v&Kd`N쩯. AJ 9.[82-aminopyrimidine, 4-aroring?8eEh#. CHEMBL488271xdPD5j .XlCNC(=O)C1=CC=C(NC2=NC=CC(=N2)C3=CN=C(C)[N]3CC4CC4)C=C1H00000000-0000-0000-0000-000000000000muRN);Q@?33@n9^MN6{8. AJ 9.[82-aminopyrimidine, 4-aroring?8eEh#. CHEMBL308848xdPD5j .XfCC1=C([N]2C=CC=CC2=N1)C3=NC(=NC=C3)NC4=C(Cl)C=CC=C4H00000000-0000-0000-0000-000000000000muRN);Q@9X ?33@to,:F.&s8;. AJ 9.[82-aminopyrimidine, 4-aroring?8eEh#. CHEMBL420677xdPD5j .XzCOC1=C(OC)C(=CC(=C1)NC2=NC=CC(=N2)C3=CN=C(C=C3)N4CCN(C)CC4)OCH00000000-0000-0000-0000-000000000000muRN);Q@?33@ZHc/FfC:R0u. AJ 9.[82-aminopyrimidine, 4-aroring?8eEh#. CHEMBL72893xdPD5j .XCOCCN[S](=O)(=O)C1=CC=C(NC2=NC(=C(SC3=CC=CC=C3)C=N2)C4=CN=C5C=CC=C[N]45)C=C1H00000000-0000-0000-0000-000000000000muRN);Q@?33@e%/EY'J. AJ 9.[82-aminopyrimidine, 4-aroring?8eEh#. CHEMBL112554xdPD5j .XtCOC1=C(OC)C(=CC(=C1)NC2=NC(=CC=N2)C3=CN=C(C=C3)N4CCCCC4)OC-y~qwo,uz?U^.iɞ៮ўPtz[%Ǽ[ҷF~zwY'lO?ڹ=V{hLN[kw OSA$7c65d63c-faff-426e-b341-c05a3a1a738058 3.47294855 -2.005012750 4.33749485 -1.502459530 4.33454418 -0.5024638770 5.20507240.0001366735810 6.07182312 -0.4986053410 6.93712139 0.002651542430 5.20216942 1.000163670 4.33757162 1.502690320 3.46704316 1.000089880 3.46111274-0.005037538240 2.60249662 1.502642870 1.7349999 1.005200150 1.73499997.04465108e-080 0.867500007 -0.4975000020000-1.02134571e-07 1.005200270 0.867499948 1.512900110 0.867500067 -1.497499940 1.73729885 -2.00136280 1.74177122 -3.006497380 0.867619216 -3.502656460-0.00217931787 -2.99879360 0.00217411411 -1.998771790 0.863217711 -4.502646920-0.00650855154 -5.006524560 -0.0109321717 -6.011714940 0.854370058 -6.513027670 1.72405112 -6.019350050 1.72847486 -5.014159680 6.06819439 1.500164270 6.06819391 2.500164270 2.60470939 2.252639530 0!0"0#0$0%0&0'0(0)0*0+0,0-0.0/00010203040506070809061             ! " #!$"%#&$'%(&)' *(+),*-+.,/-0.1/2031425364758697:8;9<00H00000000-0000-0000-0000-000000000000muRN);Q@?33@)E@. AJ 9.[82-aminopyrimidine, 4-aroring?8eEh#. CHEMBL382823xdPD5j .XtO=C(N1CCCC1)C2=CC=C(NC3=NC=CC(=N3)C4=CC5=C(S4)C=CC=C5)C=C2H00000000-0000-0000-0000-000000000000muRN);Q@?33@=1_rYG Bn+ . AJ 9.[82-aminopyrimidine, 4-aroring?8eEh#. CHEMBL418301xdPD5j .XnO=C(NC1=CC(=CC=C1)NC2=NC(=CC=N2)C3=CN=CC=C3)C4=CN=CC=C4H00000000-0000-0000-0000-000000000000muRN);Q@?33@cGPNk\]X0. AJ 9.[82-aminopyrimidine, 4-aroring?8eEh#. CHEMBL360878xdPD5j .X^CN(C1=CC=CC=C1)C2=NC(=CC=N2)C3=C4C=CC=N[N]4N=C3H00000000-0000-0000-0000-000000000000muRN);Q@M?33@zRL~ *.. AJ 9.[82-aminopyrimidine, 4-aroring?8eEh#. CHEMBL364623xdPD5j .XlCC(C)(C)C1=CC=C(NC2=NC(=CC=N2)C3=C4C=CC=N[N]4N=C3)C=C1kI嬭 ]{dyͮqo&]ϲ?mCFQp7kKD8W!ڶ:.k h!=#$h^z}SLvF^‹OIuOSA$9ddaf09c-d45c-4a10-9d39-8e62fbc932a446 8.60255718 -1.107239720 7.93893385 -0.3591728810 7.19086695 -1.022796150 8.68700027 0.3044503930 7.27531052 0.3888940810 6.29115915 0.1842649580 5.62747908 0.9323232770 5.93796396 1.882934330 5.27105474 2.628072980 4.29229116 2.423081870 3.98163414 1.467090490 3.00284958 1.262045860 2.33156991 2.003292080 2.64222693 2.959283350 3.62416363 3.17402840 2.69379973 0.3110000190 1.73599994-2.16547988e-080 0.8679999710.50790000-2.44626335e-07 -1.005800130 0.867999792 -1.503700020 1.7359997 -1.007099990 2.69379973 -1.318399910 3.28579974 -0.5035998820 6.9221158 2.087563750 7.5957818 1.341581580 5.50494528 3.34067035000000 0!0"0#0$0%0&0'0(0)0*0+0,0-049             !" #!$"%#&$'%(& )' *(+),*-+.,/-000H00000000-0000-0000-0000-000000000000muRN);Q@hr?33@2#qK=Z& EO. AJ 9.[82-aminopyrimidine, 4-aroring?8eEh#. CHEMBL515949xdPD5j .XzCOCC[S](=O)(=O)C1=CC=C(NC2=NC=CC(=N2)C3=CN=C(C)[N]3C(C)C)C=C1H00000000-0000-0000-0000-000000000000muRN);Q@49`?33@Oc@e.2O. AJ 9.[82-aminopyrimidine, 4-aroring?8eEh#. CHEMBL365318xdPD5j .XFC(F)(F)C1=C(Cl)C=CC(=C1)NC2=NC=CC(=N2)C3=C4C=CC=N[N]4N=C3C5=CC=CC=C5H00000000-0000-0000-0000-000000000000muRN);Q@49`?33@<}DBóXaǘ. AJ 9.["Imidazo pyrazines?8eEh#. CHEMBL321517xdPD5j .XjCOC(=O)C1=CC=C2N=C(NC3=C(C)C=CC=C3Cl)C4=CN=C[N]4C2=C1H00000000-0000-0000-0000-000000000000muRN);Q@" ?33@ r@ |. AJ 9.["Imidazo pyrazines?8eEh#. CHEMBL365872xdPD5j .XCN(C)CCN1CCN(CC1)C2=NC3=C(C=C2)N=C(NC4=C(C)C=CC=C4Cl)C5=CN=C[N]35H00000000-0000-0000-0000-000000000000muRN);Q@ ?33@O&d0. AJ 9.["Imidazo pyrazines?8eEh#. CHEMBL85634xdPD5j .XhCOC1=C(OC)C=C2[N]3C=NC=C3C(=NC2=C1)NC4=C(C)C=CC=C4ClH00000000-0000-0000-0000-000000000000muRN);Q@ ?33@pkEENφL 5V. AJ 9.["Imidazo pyrazines?8eEh#. CHEMBL315310xdPD5j .X`COC1=C2N=C(NC3=C(C)C=CC=C3Cl)C4=CN=C[N]4C2=CC=C1H00000000-0000-0000-0000-000000000000muRN);Q@KƠ?33@rF#w4. AJ 9.["Imidazo pyrazines?8eEh#. CHEMBL84880xdPD5j .XnCCN(CC)C1=CC2=C(C=C1)[N]3C=NC=C3C(=N2)NC4=C(Cl)C=CC=C4CH00000000-0000-0000-0000-000000000000muRN);Q@z?33@QCKeO٠etJz. AJ 9.["Imidazo pyrazines?8eEh#. CHEMBL185781xdPD5j .XCC1=C(NC2=NC3=C(N=C(C=C3)N4C[C@@H](O)[C@H](O)C4)[N]5C=NC=C25)C(=CC=C1)Cl OSA$5972c3e5-43bf-4647-9573-3ce63e7947a248C1 4.39585447 -4.960643770C2 5.26187944 -4.460643770C3 5.26187944 -3.460644010N4 4.39585447 -2.960644010C5 4.39585447 -1.960643890N6 5.26187944 -1.460643890C7 5.26187944 -0.4606439170C8 4.39585447 0.0393560790N9 4.37979507 1.080863120 C10 5.27783203 1.608617190 C11 6.17991066 1.087801690 C12 6.17188072 0.046201840 N13 5.27397728 2.608609680 C14 6.08072281 3.199508910C15 5.76804209 4.149367330H16 5.4844408 4.700702190O176.352705 4.960643770C18 4.76804972 4.145512580H19 5.04739237 4.699017520O20 4.17715025 4.952258110C21 4.46270084 3.193272350N22 3.52982879 -0.4606439170C23 2.5836091 -0.155911610N242 -0.9606439470C25 2.5836091 -1.765376210C26 3.52982879 -1.460643890C27 6.12790489 -2.960644010C28 6.99393034 -3.460644010C29 6.99393034 -4.460643770C30 6.12790489 -4.960643770Cl31 6.12790489 -1.960643890H32 4.08585453 -4.423707960 H33 3.85891891 -5.270643710!H34 4.70585442 -5.497579570"H35 3.85891843 -3.270643950#H36 6.71803713 1.395729780$H37 6.7051959 -0.2699862120%H38 6.39279032 2.663772110&H39 6.64614487 3.453866960'H40 6.96955347 4.898213390(H41 3.56080127 4.885074140)H42 3.89533496 3.443264010*H43 4.15477276 2.655145650+H44 2.3909986 0.4334110020,H45 2.3909986 -2.35469890-H46 7.53086615 -3.150644060.H47 7.53086615 -4.770643710/H48 6.12790489 -5.58064365052             !"# $!%"& #' $( %) &*'+(,)-*.+/,0-1.2/30H00000000-0000-0000-0000-000000000000muRN);Q@@?33@|>iIFM. AJ 9.["Imidazo pyrazines?8eEh#. CHEMBL315141xdPD5j .XfCN(C)C1=C2N=C(NC3=C(C)C=CC=C3Cl)C4=CN=C[N]4C2=CC=C1H00000000-0000-0000-0000-000000000000muRN);Q@n?33@1IQן. AJ 9.["Imidazo pyrazines?8eEh#. CHEMBL184115xdPD5j .XlCC1=C(NC2=NC3=CC(=C(Cl)C=C3[N]4C=NC=C24)Cl)C(=CC=C1)ClH00000000-0000-0000-0000-000000000000muRN);Q@?33@Y)PM;W 7. AJ 9.["Imidazo pyrazines?8eEh#. CHEMBL186120xdPD5j .XlCC1=C(NC2=NC3=C(N=C(NCCO)C=C3)[N]4C=NC=C24)C(=CC=C1)ClH00000000-0000-0000-0000-000000000000muRN);Q@ 7@?33@͊SJ/. AJ 9.["Imidazo pyrazines?8eEh#. CHEMBL364029xdPD5j .XnCN(CCO)C1=NC2=C(C=C1)N=C(NC3=C(C)C=CC=C3Cl)C4=CN=C[N]24H00000000-0000-0000-0000-000000000000muRN);Q@49`?33@wFP$. AJ 9.["Imidazo pyrazines?8eEh#. CHEMBL426818xdPD5j .XtCC1=C(NC2=NC3=C(N=C(C=C3)N4CCOCC4)[N]5C=NC=C25)C(=CC=C1)ClH00000000-0000-0000-0000-000000000000muRN);Q@49`?33@5XpxD͍w2. AJ 9.["Imidazo pyrazines?8eEh#. CHEMBL365529xdPD5j .XrCC1=C(NC2=NC3=CC=C(C=C3[N]4C=NC=C24)[N](=O)=O)C(=CC=C1)ClH00000000-0000-0000-0000-000000000000muRN);Q@49`?33@eŲэN΄\q. AJ 9.["Imidazo pyrazines?8eEh#. CHEMBL322640xdPD5j .XzCOC1=C(NCCN2CCOCC2)C=C3N=C(NC4=C(C)C=CC=C4Cl)C5=CN=C[N]5C3=C1H00000000-0000-0000-0000-000000000000muRN);Q@?33@ a3Fo]. AJ 9.["Imidazo pyrazines?8eEh#. CHEMBL322640xdPD5j .XxCC1CN(CC(C)N1)C2=CC=C3[N]4C=NC=C4C(=NC3=C2)NC5=C(C)C=CC=C5ClH00000000-0000-0000-0000-000000000000muRN);Q@?33@ƲA; j. AJ 9.[Amino purines?8eEh#. CHEMBL314397xdPD5j .XnCOC1=CC=C(CNC2=C3N=C[N](CC(C)C)C3=NC(=N2)N(CCO)CCO)C=C1H00000000-0000-0000-0000-000000000000muRN);Q@ @?33@T.wwnD/0 m. AJ 9.[Amino purines?8eEh#. CHEMBL280074xdPD5j .XRC[N]1C=NC2=C(NCC3=CC=CC=C3)N=C(NCCO)N=C12H00000000-0000-0000-0000-000000000000muRN);Q@ O\ ?33@zrTM.>7. AJ 9.[Amino purines?8eEh#. CHEMBL336016xdPD5j .XfCC(C)[N]1C=NC2=C(NCC3=CC=CC=C3)N=C(N=C12)N4CCC(O)C4H00000000-0000-0000-0000-000000000000muRN);Q@j?33@?Iˏ. AJ 9.[Amino purines?8eEh#. CHEMBL84944xdPD5j .XnCC(C)C(CO)NC1=NC2=C(N=C[N]2C(C)C)C(=N1)NCC3=CC(=CC=C3)OH00000000-0000-0000-0000-000000000000muRN);Q@@?33@B&u. AJ 9.[Amino purines?8eEh#. CHEMBL568080xdPD5j .XCC(C)[N]1C=NC2=C(NCC3=CC=C(C=C3)[N]4C=CC=C4)N=C(N[C@@H]5CC[C@@H](N)CC5)N=C12H00000000-0000-0000-0000-000000000000muRN);Q@@?33@h'8lBuc). AJ 9.[Amino purines?8eEh#. CHEMBL568303xdPD5j .XCC(C)[N]1C=NC2=C(NCC3=CN=C(C=C3)C4=CC=CS4)N=C(N[C@@H]5CC[C@@H](N)CC5)N=C12H00000000-0000-0000-0000-000000000000muRN);Q@@?33@GM!UxL ). AJ 9.[Amino purines?8eEh#. CHEMBL568310xdPD5j .XCC(C)[N]1C=NC2=C(NCC3=CN=C(C=C3)C4=CC(=CC=C4)F)N=C(N[C@@H]5CC[C@@H](N)CC5)N=C127ϯ'䪏yv}w?{v?[?78(i~-Vg/Wv;e{/M?˯ OSA$6bedef96-54c0-46f8-88be-3859640d281866 3.11290836 -2.985330340 2.13477087 -2.777371410 1.46560431 -3.520483970 1.82579994 -1.826299910 2.41779995 -1.011499880 1.82579994 -0.1968998910 0.868000031-0.507900001.84131366e-0710 -0.86602509 1.500000240 -0.866024733 2.500000240 -1.73582327 3.003863330 -1.74029529 4.008997920 -0.866143167 4.505156520 0.00365517824 4.001293660-0.000698601187 3.001271720 -0.861741304 5.505146980 0.0124107935 6.001306530 0.00793787371 7.006441120 -0.861860693 7.51030350 -1.72718644 7.00903130 -1.73153985 6.009009840  0.873212576 7.507739070 -0.868000567 -0.5079001190 -0.868000269 -1.513700130 -1.73332381 -2.014914040 -1.73192179 -3.014913080 -0.859213531 -3.513719320 -0.857763469 -4.51374960 -1.72016585 -5.020034790 -1.7143625 -6.02001810 -2.59287381 -4.521228310 -2.60317945 -3.516136880!-9.89074067e-08 -2.011600020" 0.867999852 -1.514999990# 0.649519265 1.374999880$ -2.38336802 -1.640825150% -1.0626781 -6.39124250& -2.36169434 -6.39878130'0(0)0*0+0,0-0.0/000102030405060708StereoHydrogen -2.60011673 -2.51868963090:0;0<0=StereoHydrogen -0.8508811 -5.51434660>0?0@0A070""             !"# $!%!"&#'$(%)&*'+(,)-*.+/,0-1.2/ 30 41 5263748596:7;8<9=:>;?<@=A>B?C@ DA E028 =H00000000-0000-0000-0000-000000000000muRN);Q@@?33@7! YL_$V. AJ 9.[Amino purines?8eEh#. CHEMBL584355xdPD5j .XCCN[C@@H]1CC[C@H](CC1)NC2=NC3=C(N=C[N]3C(C)C)C(=N2)NCC4=CC=C(C=C4)C5=CC=CC=C5H00000000-0000-0000-0000-000000000000muRN);Q@@?33@#\2 AKus. AJ 9.[Amino purines?8eEh#. CHEMBL423582xdPD5j .XN[C@@H]1CC[C@H](CC1)NC2=NC3=C(N=C[N]3C4CCCC4)C(=N2)NCC5=CC=CC(=C5)IH00000000-0000-0000-0000-000000000000muRN);Q@49`?33@]eLSgA". AJ 9.[Amino purines?8eEh#. CHEMBL566550xdPD5j .XCC(C)[N]1C=NC2=C(NCC3=CC=C(S3)C4=CC=CS4)N=C(N[C@@H]5CC[C@@H](N)CC5)N=C12H00000000-0000-0000-0000-000000000000muRN);Q@ =?33@`NMI|,_^F. AJ 9.[Amino purines?8eEh#. CHEMBL568311xdPD5j .XCOC1=CC=CC(=C1)C2=CC=C(CNC3=C4N=C[N](C(C)C)C4=NC(=N3)N[C@@H]5CC[C@@H](N)CC5)S2H00000000-0000-0000-0000-000000000000muRN);Q@?33@o4r"B=`w8l. AJ 9.[Amino purines?8eEh#. CHEMBL566971xdPD5j .XCC(C)[N]1C=NC2=C1N=C(N[C@@H]3CC[C@@H](N)CC3)N=C2NCC4=CC=C(C=C4)C5=CC(=CS5)CH00000000-0000-0000-0000-000000000000muRN);Q@Ơ?33@2XL :7+. AJ 9.[Amino purines?8eEh#. CHEMBL84436xdPD5j .XjC[C@@H](O)CNC1=NC(=C2N=C[N](C(C)C)C2=N1)NCC3=CC=CC=C3H00000000-0000-0000-0000-000000000000muRN);Q@Ơ?33@OWy%BD". AJ 9.[Amino purines?8eEh#. CHEMBL568301xdPD5j .XCC(C)[N]1C=NC2=C(NCC3=CC=C(S3)C4=CC=C(F)C=C4)N=C(N[C@@H]5CC[C@@H](N)CC5)N=C12H00000000-0000-0000-0000-000000000000muRN);Q@Ơ?33@!F@51T }. AJ 9.[Amino purines?8eEh#. CHEMBL568093xdPD5j .XCC(C)[N]1C=NC2=C(NCC3=CN=C(C=C3)C4=CSC=C4)N=C(N[C@@H]5CC[C@@H](N)CC5)N=C12H00000000-0000-0000-0000-000000000000muRN);Q@Ơ?33@j@bG. AJ 9.[Amino purines?8eEh#. CHEMBL572943xdPD5j .XCCCCN(CCCC)[C@@H]1CC[C@H](CC1)NC2=NC3=C(N=C[N]3C(C)C)C(=N2)NCC4=CC=C(C=C4)C5=CC=CC=C5H00000000-0000-0000-0000-000000000000muRN);Q@hr?33@,G7jJ!U. AJ 9.[Amino purines?8eEh#. CHEMBL568079xdPD5j .XCC(C)[N]1C=NC2=C(NCC3=CC=C(S3)C4=CC(=CC=C4)F)N=C(N[C@@H]5CC[C@@H](N)CC5)N=C12H00000000-0000-0000-0000-000000000000muRN);Q@hr?33@^69Fd!. AJ 9.[Amino purines?8eEh#. CHEMBL566972xdPD5j .XCC(C)[N]1C=NC2=C(NCC3=CC=C(C=C3)C4=CN=CC=C4)N=C(N[C@@H]5CC[C@@H](N)CC5)N=C12H00000000-0000-0000-0000-000000000000muRN);Q@@?33@9A1. AJ 9.[Amino purines?8eEh#. CHEMBL568311xdPD5j .XCC(C)[N]1C=NC2=C1N=C(N[C@@H]3CC[C@@H](N)CC3)N=C2NCC4=CC=C(C=C4)C5=CC=C(C)S5H00000000-0000-0000-0000-000000000000muRN);Q@@?33@8.[aAtmA. AJ 9.[Amino purines?8eEh#. CHEMBL578865xdPD5j .XCC(C)[N]1C=NC2=C(NCC3=CC=C(C=C3)C4=CC=C(Cl)S4)N=C(N[C@@H]5CC[C@@H](N)CC5)N=C12H00000000-0000-0000-0000-000000000000muRN);Q@@?33@C)@O֝h"@ . AJ 9.[Amino purines?8eEh#. CHEMBL76925xdPD5j .XxCC(C)[N]1C=NC2=C(NCC3=CC4=CC=CC=C4C=C3)N=C(N=C12)N5CCCCC5CCOH00000000-0000-0000-0000-000000000000muRN);Q@A?33@oDS5G*ht[G. AJ 9.[Amino purines?8eEh#. CHEMBL573263xdPD5j .XCC(C)[N]1C=NC2=C(NCC3=CC=C(C=C3)C4=CC=CC=C4)N=C(N[C@@H]5CC[C@H](CC5)NC(C)=O)N=C12H00000000-0000-0000-0000-000000000000muRN);Q@@?33@87@#$;5. AJ 9.[Amino purines?8eEh#. CHEMBL576375xdPD5j .XCCCN[C@@H]1CC[C@H](CC1)NC2=NC3=C(N=C[N]3C(C)C)C(=N2)NCC4=CC=C(C=C4)C5=CC=CC=C5H00000000-0000-0000-0000-000000000000muRN);Q@@?33@d.E]G?h<. AJ 9.[Amino purines?8eEh#. CHEMBL90454xdPD5j .XnCOC1=CC=C(CNC2=C3N=C[N](C(C)C)C3=NC(=N2)NC(C)(O)CO)C=C1H00000000-0000-0000-0000-000000000000muRN);Q@49`?33@Y!KKM3k. AJ 9.[Amino purines?8eEh#. CHEMBL573262xdPD5j .XCC(C)[N]1C=NC2=C(NCC3=CC=C(C=C3)C4=CC=CC=C4)N=C(N[C@@H]5CCCC[C@@H]5N)N=C12_7ϯ'㪇x7u|G5{v=ۺ?s},O~-g/Ww{v;zu{/L?ˎ OSA$b83e90d5-11c6-4156-b78b-d5f480e2af8367 3.11290836 -2.985330340 2.13477087 -2.777371410 1.46560431 -3.520483970 1.82579994 -1.826299910 2.41779995 -1.011499880 1.82579994 -0.1968998910 0.868000031-0.507900001.84131366e-0710 -0.86602509 1.500000240 -0.866024733 2.500000240 -1.73803246 3.000030280 -1.73808014 4.000061510 -0.874968648 4.505136970-0.00296101021 4.005106930 0.00593505288 3.000001670 -0.879369676 5.505127430 -1.75356984 6.001314640 -1.75801897 7.00133610 -0.897138774 7.510205270 -0.0229388271 7.014018540-0.00961899944 6.008962150 -0.868000567 -0.5079001190 -0.868000269 -1.513700130 -1.73332381 -2.014914040 -1.73192179 -3.014913080 -0.865893602 -3.514971490 -0.860138297 -4.514986040 -1.72922957 -5.020067690 -2.60407615 -4.525134560 -2.60101295 -3.519994740 -3.46698976 -3.019910570 -9.89074067e-08 -2.011600020! 0.867999852 -1.514999990" 0.649519265 1.374999880# -2.38336802 -1.640825150$ -4.1165452 -3.394847390% -3.4669168 -2.269910570&0'0(0)0*0+0,0-0.0/00010203040506070809StereoHydrogen -0.86622113 -2.514351130:0;0<0=0>0?0@0A0BStereoHydrogen -3.46560669 -4.02246618071!!            !"# $ !%"&#'$(%)&*'+(,)-*.+/,0-1. 2/ 30 41 5263748596:7;8<9=:>;?<@=A>B?C@DAEBF029BH00000000-0000-0000-0000-000000000000muRN);Q@49`?33@VY&Bd. AJ 9.[Amino purines?8eEh#. CHEMBL80713xdPD5j .XlCOC1=CC=C(CNC2=C3N=C[N](C(C)C)C3=NC(=N2)N(CCO)CCO)C=C1H00000000-0000-0000-0000-000000000000muRN);Q@49`?33@u^. AJ 9.[Amino purines?8eEh#. CHEMBL574150xdPD5j .XCC(C)[N]1C=NC2=C(NCC3=CC=C(C=C3)C4=CC=CC=C4)N=C(NC5(CO)CCCC5)N=C12H00000000-0000-0000-0000-000000000000muRN);Q@/?33@_C. AJ 9.[Amino purines?8eEh#. CHEMBL573263xdPD5j .XvCC(C)[N]1C=NC2=C(NCC3=CC=C(C=C3)C4=CC=CC=C4)N=C(NCCCN)N=C12H00000000-0000-0000-0000-000000000000muRN);Q@/?33@^SG@q;a. AJ 9.[Amino purines?8eEh#. CHEMBL90628xdPD5j .XhCOC1=CC=C(CNC2=C3N=C[N](C(C)C)C3=NC(=N2)NC(O)CN)C=C1H00000000-0000-0000-0000-000000000000muRN);Q@?33@9 }M#KUw. AJ 9.[Amino purines?8eEh#. CHEMBL80750xdPD5j .XbCOC1=CC=C(CNC2=C3N=C[N](C(C)C)C3=NC(=N2)NCCO)C=C1H00000000-0000-0000-0000-000000000000muRN);Q@?33@tdFp*QK6n. AJ 9.[Amino purines?8eEh#. CHEMBL420571xdPD5j .X~COC1=CC=C(CNC2=C3N=C[N](C(C)C)C3=NC(=N2)N(CCO)CC4=CC=CC=C4)C=C1H00000000-0000-0000-0000-000000000000muRN);Q@?33@Fw*#. AJ 9.[Amino purines?8eEh#. CHEMBL90082xdPD5j .XnCOC1=CC=C(CNC2=C3N=C[N](C(C)C)C3=NC(=N2)NC4CCCCC4O)C=C1H00000000-0000-0000-0000-000000000000muRN);Q@?33@8 DBK ٺ. AJ 9.[Amino purines?8eEh#. CHEMBL90549xdPD5j .X~CC(C)[N]1C=NC2=C(NCC3=CC=C(C=C3)C4=CC=CC=C4)N=C(N=C12)N(CCO)CCOH00000000-0000-0000-0000-000000000000muRN);Q@?33@#eL9RXTI. AJ 9.[Amino purines?8eEh#. CHEMBL150272xdPD5j .XN[C@H]1CC[C@@H](CC1)NC2=NC3=C(N=C[N]3C4CCCC4)C(=N2)NCC5=CC=CC=C5H00000000-0000-0000-0000-000000000000muRN);Q@KƠ?33@UAݲP)X. AJ 9.[Amino purines?8eEh#. CHEMBL93626xdPD5j .XCOC1=CC=C(CNC2=NC(=NC3=C2N=C[N]3CC4=CC=C(C=C4)[N](=O)=O)N(CCO)CCO)C=C1H00000000-0000-0000-0000-000000000000muRN);Q@Ơ?33@o~A8^(Һ. AJ 9.[Amino purines?8eEh#. CHEMBL91212xdPD5j .XbCC(C)[N]1C=NC2=C(NC3=CC=CC=C3)N=C(N=C12)N(CCO)CCOH00000000-0000-0000-0000-000000000000muRN);Q@Ơ?33@'u2~#Av IIF. AJ 9.[Amino purines?8eEh#. CHEMBL75924xdPD5j .XpCOC1=CC=C(CNC2=C3N=C[N](C(C)C)C3=NC(=N2)N4CCC(O)CC4)C=C1H00000000-0000-0000-0000-000000000000muRN);Q@Ơ?33@jIA߇Mvk?. AJ 9.[Amino purines?8eEh#. CHEMBL92544xdPD5j .XlCC(C)[N]1C=NC2=C(NCC3=CC=C(Br)C=C3)N=C(N=C12)N(CCO)CCOH00000000-0000-0000-0000-000000000000muRN);Q@Ơ?33@65J@[42Q. AJ 9.[Amino purines?8eEh#. CHEMBL91360xdPD5j .XlCCCCC1=CC=C(CNC2=NC(=NC3=C2N=C[N]3C(C)C)N(CCO)CCO)C=C1H00000000-0000-0000-0000-000000000000muRN);Q@Ơ?33@QcHk!e. AJ 9.[Amino purines?8eEh#. CHEMBL461557xdPD5j .XCC[C@H](CO)NC1=NC2=C(N=C[N]2C(C)C)C(=N1)NCC3=CC=C(C=C3)C4=CC=CC=C4H00000000-0000-0000-0000-000000000000muRN);Q@Ơ?33@xtG=nN?O. AJ 9.[Amino purines?8eEh#. CHEMBL90860xdPD5j .XCOC1=CC=C(CNC2=C3N=C[N](C(C)C)C3=NC(=N2)NCCC4=C[NH]C5=CC=CC=C45)C=C1H00000000-0000-0000-0000-000000000000muRN);Q@Ơ?33@FBMi_DѾ. AJ 9.[Amino purines?8eEh#. CHEMBL574156xdPD5j .XCC(C)[N]1C=NC2=C(NCC3=CC=C(C=C3)C4=CC=CC=C4)N=C(NC5CCCC(N)C5)N=C12H00000000-0000-0000-0000-000000000000muRN);Q@Ơ?33@ F4A=Pt. AJ 9.[Amino purines?8eEh#. CHEMBL133498xdPD5j .XlCOC1=CC=C(CNC2=C3N=C[N](C(C)C)C3=NC(=N2)N4CCCC4CO)C=C1 OSA$9523373a-e2e1-4380-a33b-f78a050b172457C1 3.58267617 -5.528330330O2 4.44870138 -5.028330330C3 4.44870138 -4.028330330C4 3.58267617 -3.528330560C5 3.58267617 -2.528330560C6 4.44870138 -2.028330560C7 4.44870138 -1.028330560N8 5.31472683 -0.5283305640C9 5.31472683 0.4716694650 C10 6.18075228 0.9716694360 N11 7.1269722 0.6669371720 C12 7.7105813 1.471669440 N13 7.1269722 2.276401760 C14 7.43763447 3.226922040C15 6.76979065 3.971223830C16 8.41614056 3.433140750C17 6.18075228 1.971669440N18 5.31472683 2.471669440C19 4.44870138 1.971669440N20 4.44870138 0.9716694360N21 3.58267617 2.471669440C22 2.66913056 2.064932820C232 2.808077570C242.5 3.674103020C25 3.47814751 3.466191290C26 4.2212925 4.135322090O27 4.01338053 5.11346960C28 5.31472683 -2.528330560C29 5.31472683 -3.528330560H30 3.27267623 -4.991394520H31 3.04574037 -5.838330270H32 3.89267612 -6.065266130 H33 3.04574037 -3.838330510!H34 3.04574037 -2.218330620"H35 4.23664904 -0.4457211490#H36 3.83812046 -1.135992410$H37 5.85166264 -0.8383305670%H38 8.33058167 1.471669440&H39 7.63024521 3.81624460'H40 7.23125744 4.385286810(H41 6.35572767 4.432690620)H42 6.30832386 3.557160850*H43 8.54399586 2.826467040+H44 9.0228138 3.560996290,H45 8.28828526 4.039814470-H46 2.16754007 1.700505970.H47 2.97913051 1.527997020/H48 1.49840951 3.1725044300H49 1.58513904 2.3473277101H50 2.69159055 4.2637581802H51 1.93360186 3.9262797803H52 4.05696726 3.244003304H53 4.54984236 3.6095323605H54 4.79614639 4.3675785106H55 4.47413063 5.5283303307H56 5.85166264 -2.2183306208H57 5.85166264 -3.83833051060             !" #!$"%#&$' %( &)'*(+),*-+.,/-0.1/2031425364758697:8;0H00000000-0000-0000-0000-000000000000muRN);Q@9`?33@ ,B#!A. AJ 9.[Amino purines?8eEh#. CHEMBL328678xdPD5j .XCOC1=CC=C(CNC2=NC(=NC3=C2N=C[N]3CC4=C(C=CC=C4)C5=CC=CC=C5)N(CCO)CCO)C=C1H00000000-0000-0000-0000-000000000000muRN);Q@@?33@7 F'l . AJ 9.[Amino purines?8eEh#. CHEMBL573925xdPD5j .XCC(C)[N]1C=NC2=C(NCC3=CC=C(C=C3)C4=CC=CC=C4)N=C(N=C12)N5CCC(N)C5H00000000-0000-0000-0000-000000000000muRN);Q@@?33@;aw4EΧs. AJ 9.[Amino purines?8eEh#. CHEMBL90300xdPD5j .XCOC1=CC=C(CNC2=C3N=C[N](C(C)C)C3=NC(=N2)N(C)CC(O)C4=CC(=C(O)C=C4)O)C=C1H00000000-0000-0000-0000-000000000000muRN);Q@@?33@S,&Fnp. AJ 9.[Amino purines?8eEh#. CHEMBL328316xdPD5j .XCC(C)[N]1C=NC2=C(NCC3=CC=C(C=C3)C4=CC=CC=C4)N=C(NCC5=CC=CO5)N=C12H00000000-0000-0000-0000-000000000000muRN);Q@49`?33@`.AL. AJ 9.[Amino purines?8eEh#. CHEMBL88694xdPD5j .XpCOC1=CC=C(CNC2=C3N=C[N](C(C)C)C3=NC(=N2)N(CC=C)CC=C)C=C1H00000000-0000-0000-0000-000000000000muRN);Q@49`?33@!ȭMJRbz. AJ 9.[Amino purines?8eEh#. CHEMBL330111xdPD5j .XbCOC1=CC=C(CNC2=C3N=C[N](C(C)C)C3=NC(=N2)NCCN)C=C1H00000000-0000-0000-0000-000000000000muRN);Q@49`?33@]pCЍ\. AJ 9.[Amino purines?8eEh#. CHEMBL90233xdPD5j .XxCC(O)NC1=NC(=C2N=C[N](C(C)C)C2=N1)NCC3=CC=C(C=C3)C4=CC=CC=C4H00000000-0000-0000-0000-000000000000muRN);Q@49`?33@T(g,K֦v. AJ 9.[Amino purines?8eEh#. CHEMBL433154xdPD5j .XhCOC1=CC=C(CNC2=C3N=C[N](C(C)C)C3=NC(=N2)N4CCCC4)C=C1_vﯯ$ທu|G5c{vݘ5[7s}8(iO-/W{w;je{+\OSA$09e8dfa5-8264-48a1-8e3c-fc426692c55c53 0.00647383928 6.001329420 -0.861743748 5.505146030 -0.866145134 4.505155560 0.00365335657 4.001293180-0.000699912489 3.001271720 -0.866025746 2.499999760 -0.866025507 1.499999760-3.93881159e-08 0.999999940000 0.868000209 -0.5078993440 1.82580018 -0.1968995930 2.41779995 -1.011499640 1.82580006 -1.826299550 2.13477087 -2.777370930 3.11290836 -2.985330340 1.46560407 -3.520483020 0.86800009 -1.5149996302.44586772e-07 -2.011599780 -0.867999732 -1.513699890 -0.867999971-0.50790 -1.7333231 -2.014913560 -2.64865661 -1.611106040 -3.31986952 -2.352408170 -2.81922889 -3.21979570 -1.83893347 -3.013995890 -1.73582447 3.00386190 -1.74029696 4.008996490 0.649518847 1.3750001200000 0!0"0#0$0%0&0'0(0)0*0+0,0-0.0/0001020304056               !" #!$"%# &$ '%(&)'*(+),*-+.,/-0.1/2031425364700H00000000-0000-0000-0000-000000000000muRN);Q@49`?33@a:)K Jq5. AJ 9.[Amino purines?8eEh#. CHEMBL90707xdPD5j .XZCOC1=CC=C(CNC2=C3N=C[N](C)C3=NC(=N2)NCCO)C=C1H00000000-0000-0000-0000-000000000000muRN);Q@49`?33@DQv@צe@Z7M. AJ 9.[Amino purines?8eEh#. CHEMBL576357xdPD5j .XCC(C)[N]1C=NC2=C(NC(C)C3=CC=C(C=C3)C4=CC=CC=C4)N=C(N[C@@H]5CC[C@@H](N)CC5)N=C12H00000000-0000-0000-0000-000000000000muRN);Q@49`?33@_{>B>G1 . AJ 9.[Amino purines?8eEh#. CHEMBL573465xdPD5j .XCCN(CC)[C@@H]1CC[C@H](CC1)NC2=NC3=C(N=C[N]3C(C)C)C(=N2)NCC4=CC=C(C=C4)C5=CC=CC=C5H00000000-0000-0000-0000-000000000000muRN);Q@T?33@bQFU8G. AJ 9.[Amino purines?8eEh#. CHEMBL86066xdPD5j .XZCC(C)[N]1C=NC2=C(NCC3=CC=CC=C3)N=C(NCCO)N=C12H00000000-0000-0000-0000-000000000000muRN);Q@cT?33@ߊMFś&5y3. AJ 9.[Amino purines?8eEh#.CHEMBL1643251xdPD5j .XVCOC1=CC(=C(OC)C=C1)NC2=NC(=NC3=C2N=C[NH]3)NH00000000-0000-0000-0000-000000000000muRN);Q@?33@3|-?L\Lxm. AJ 9.[Amino purines?8eEh#. CHEMBL323417xdPD5j .XnCC(C)C(CO)NC1=NC2=C(N=C[N]2C(C)C)C(=N1)NCC3=CC=C(O)C=C3H00000000-0000-0000-0000-000000000000muRN);Q@?33@IG7. AJ 9.[Amino purines?8eEh#. CHEMBL377131xdPD5j .XzCOC1=CC=C(CNC2=C3N=C[N](C(C)C)C3=NC(=N2)C4=CC=C(C=O)C=C4)C=C1H00000000-0000-0000-0000-000000000000muRN);Q@`?33@KC{O}]. AJ 9.[,2,4-diaminopyrimidines?8eEh#. CHEMBL455651xdPD5j .XCCN(CC)C(=O)C1=CC=C(NC2=NC(=C(C=N2)C(F)(F)F)N[C@@H]3CCC[C@H]3N(C)C)C=C1H00000000-0000-0000-0000-000000000000muRN);Q@"?33@Ehc!G/̒. AJ 9.["Amino quinazoline?8eEh#. CHEMBL411224xdPD5j .XCC1=C(OC2CCN(CC2)C(=O)CC(C)(C)C)C=CC(=C1)NC3=NC=NC4=CN=C(C=C34)N5CCOCC5H00000000-0000-0000-0000-000000000000muRN);Q@!׍@?33@DkKD9Y. AJ 9.["Amino quinazoline?8eEh#. CHEMBL434257xdPD5j .X|CCOC1=C(OCC)C=C2C(=NC(=NC2=C1)CCCCl)NC3=CC(=CC=C3)C4=CSC(=N4)CH00000000-0000-0000-0000-000000000000muRN);Q@!q&?33@Hd"Bn. AJ 9.["Amino quinazoline?8eEh#. CHEMBL126997xdPD5j .XlCCOC1=C(OCC)C=C2C(=NC=NC2=C1)NC3=CC(=CC=C3)C4=CN=CN=C4H00000000-0000-0000-0000-000000000000muRN);Q@!e`?33@H@. AJ 9.["Amino quinazoline?8eEh#. CHEMBL430434xdPD5j .XC[C@H](OC1=CC=CC2=C1C(=NC=N2)NC3=CC(=C(OC4=CN=C(C)C=C4)C=C3)C)C(=O)N5CCOCC5H00000000-0000-0000-0000-000000000000muRN);Q@!["?33@%LCG Lh/,. AJ 9.["Amino quinazoline?8eEh#. CHEMBL340904xdPD5j .XhCCOC1=C(OCC)C=C2C(=NC=NC2=C1)NC3=CC(=CC=C3)C4=CN=CS4H00000000-0000-0000-0000-000000000000muRN);Q@! Ơ?33@O.3nD `z . AJ 9.["Amino quinazoline?8eEh#. CHEMBL126549xdPD5j .XnCCOC1=C(OCC)C=C2C(=NC=NC2=C1)NC3=CC(=CC=C3)C4=CSC(=N4)CH00000000-0000-0000-0000-000000000000muRN);Q@! Ơ?33@zN[E8d. AJ 9.["Amino quinazoline?8eEh#. CHEMBL518826xdPD5j .XCC(C)(OC1=C2C(=NC=NC2=CC=C1)NC3=CC(=C(OCC4=NC=CC=C4)C=C3)Cl)C(N)=OH00000000-0000-0000-0000-000000000000muRN);Q@ Ơ?33@}."fD'`e-e. AJ 9.["Amino quinazoline?8eEh#. CHEMBL171439xdPD5j .XjCOC1=C(NC2=NC=NC3=CC(=C(OC)C=C23)OCCCN4CCOCC4)C=CC=C1H00000000-0000-0000-0000-000000000000muRN);Q@ ?33@sID!eDi. AJ 9.["Amino quinazoline?8eEh#. CHEMBL488436xdPD5j .XCOC(=O)CNCC1=CC=C(O1)C2=NC=C3N=CN=C(NC4=CC=C(OCC5=CC=CC=C5)C=C4)C3=C2{~wd>w=ϟǷ>w?W_os{ylczwwg߿? OSA$2296964d-30ef-438c-9407-ce91bb3704a962 -6.65299129 -1.220906730 -6.24719572 -0.3069427610 -5.25278187 -0.2013898490 -4.66416359 -1.009801030 -4.84698677 0.7125741840 -3.85257316 0.8181270360 -3.44677782 1.732091070 -2.45236397 1.837643860 -1.9559232 2.705746650 -0.976004004 2.498960020 -0.867468238 1.503192540 -1.78446746 1.092787980 0 1.005699990 000 0.867899835 -0.4978002310 1.73709989-4.86199326e-070 2.60379982 -0.4989005030 3.47479987 0.002199356910 3.47350001 1.007899280 2.6012001 1.512399550 2.59852886 2.512395860 3.46321559 3.014707330 4.33360386 2.511864660 5.19834185 3.014150380 5.2015233 4.014176370 6.0684123 4.512677190 6.93357134 4.011179920 7.80046034 4.509680750 8.66862679 4.003012180 9.53556728 4.501487260 9.54314995 5.501489640 8.67498302 6.008158210 7.79923344 5.514824390! 4.3311348 4.517019270" 3.45756507 4.019835950# 1.73580003 1.005699750$ 0.867900193 1.513499860% -3.41110945 0.2118186060& 1.94801044 2.885659690'0(0)0*0+0,0-0.0/000102030405060708090:0;0<0=066         $   #"  !"# $!%!"&#'#$(%)&*'+(,)-*.+/,0-1.2/ 30415263748596:7;8<9=: >;!?<"@=$A00H00000000-0000-0000-0000-000000000000muRN);Q@ q?33@Ƶ O',*. AJ 9.["Amino quinazoline?8eEh#. CHEMBL510436xdPD5j .XlOC(=O)\C=C\C(=O)CC1=CC=C2N=CN=C(NC3=CC=CC(=C3)Br)C2=C1H00000000-0000-0000-0000-000000000000muRN);Q@ q?33@#N{H̸Dx. AJ 9.[Odds?8eEh#. CHEMBL520187xdPD5j .XpCN1CCN(CCCOC2=C(C)C=C3C(=C(C=NC3=C2)C#N)NC4=NC=CC=C4)CC1H00000000-0000-0000-0000-000000000000muRN);Q@ 1?33@ FQOaXX. AJ 9.["Amino quinazoline?8eEh#. CHEMBL136397xdPD5j .XbC\C=C\C(=O)NC1=NC=C2N=CN=C(NC3=CC(=CC=C3)Br)C2=C1ynb޽ۓe׷[{uʒ}^vo?yn\.|xm{q뢏E7]OSA$2be7794f-3b1d-42d4-85bb-148b39cfa89538 -4.33155537 1.49317110 -3.46408701 0.9956786630 -2.59951162 1.498181940 -1.7320435 1.000689270 -1.729150770.0006934404370 -0.867468238 1.5031925400 1.005699990000 0.867899835 -0.4978002310 1.73709989-4.86199326e-070 2.60379982 -0.4989005030 3.47479987 0.002199356910 3.47350001 1.007899280 2.6012001 1.512399550 2.59852886 2.512395860 3.46321559 3.014707330 3.45756555 4.019836430 4.33113575 4.51701880 5.20152378 4.014175420 5.19834185 3.014149190 4.33360386 2.511863950# 4.33436537 5.517013550 1.73580003 1.005699750 0.867900193 1.513499860 -0.869638145 2.253189330 1.94801044 2.885659690000000 0!0"0#0$0%040              ! "!#"$#%$&%'00H00000000-0000-0000-0000-000000000000muRN);Q@ b@?33@|MJfU'. AJ 9.[Odds?8eEh#. CHEMBL426619xdPD5j .XbCC1=NC2=C([NH]1)C=C3N=CN=C(NC4=CC(=CC=C4)Br)C3=C2H00000000-0000-0000-0000-000000000000muRN);Q@ ?33@u 4HӭCTdp. AJ 9.[82-aminopyrimidine, 4-aroring?8eEh#. CHEMBL404504xdPD5j .XbN#CC1=C(NC2=NC(=CC=C2)C3=CN=C4C=CC=C[N]34)C=CC=C1Y7]cm$oeNq&ԆŅ~:y-=Fv{Qi U7&ZekB[]Oɞ_ko!pSMN  V$dZ]1k\/M3"]OSA$f8aecb77-bf08-460c-9c8b-0dd6e85539ea37 4.60847425 4.370693210 3.94488692 5.118792060 3.28129983 5.866890910 2.29713869 5.662309170 1.98248243 4.713103770 2.64719033 3.96600080 2.32810187 3.012849330 3.00285006 2.267845870 3.98670411 2.473903180 4.29580879 3.424963950 3.63104367 4.172058110 2.69379997 1.316800120 3.28579974 0.5022000670 2.69379973 -0.3125998970 1.73599982-0.001299918630 0.867999971 -0.4979000090000-1.09945098e-07 1.005800720 0.868000031 1.51370060 1.73599994 1.005800370 1.63349462 6.410399910 1.94402564 7.360995770 2.92818689 7.565577510 3.60181713 6.819562910 1.24795926 4.5615267800000000 0!0"0#0$040                !" #!$"%#&$'00H00000000-0000-0000-0000-000000000000muRN);Q@ ?33@90O . AJ 9.[82-aminopyrimidine, 4-aroring?8eEh#. CHEMBL257831xdPD5j .XCOC1=CC=C(C=C1)[S](=O)(=O)NC2=CC=C(C=C2)C3=NC(=NC=C3)NC4=CC5=C(C=C4)N=CS5H00000000-0000-0000-0000-000000000000muRN);Q@ ?33@7ABQM. AJ 9.["Amino quinazoline?8eEh#. CHEMBL193210xdPD5j .X\ClCC(=O)NC1=CC=C2N=CN=C(NC3=CC=CC(=C3)Br)C2=C1H00000000-0000-0000-0000-000000000000muRN);Q@ ?33@8$J4*-. AJ 9.["Amino quinazoline?8eEh#. CHEMBL473631xdPD5j .XCOC1=C(OC)C=C2C(=NC=NC2=C1)NC3=CC(=C(C=C3)C4=NC5=C(S4)C=CC=C5)OCH00000000-0000-0000-0000-000000000000muRN);Q@ ?33@͹LR8$. AJ 9.[Odds?8eEh#. CHEMBL556881xdPD5j .XZCC1=NC(=CC=C1)C2=NC(=C3SC=CC3=N2)NC4=CC=NC=C4H00000000-0000-0000-0000-000000000000muRN);Q@j?33@ٴ尭@ ];. AJ 9.["Amino quinazoline?8eEh#. CHEMBL424696xdPD5j .XCOC1=NC(=C(Cl)C=C1)NC2=NC=NC3=C2C(=CC(=C3)OCCCN4CCOCC4)OC5CCOCC5H00000000-0000-0000-0000-000000000000muRN);Q@j?33@$"Я4K -c:AZr. AJ 9.[82-aminopyrimidine, 4-aroring?8eEh#. CHEMBL255932xdPD5j .XCC1=C[N](C=N1)C2=CC(=CC(=C2)NC(=O)C3=CC(=C(C)C=C3)NC4=NC(=CC=N4)C5=CN=CC=C5)C(F)(F)FH00000000-0000-0000-0000-000000000000muRN);Q@/?33@XLBauk. AJ 9.[82-aminopyrimidine, 4-aroring?8eEh#. CHEMBL297570xdPD5j .XlCN(C1=CC(=CC=C1)[N](=O)=O)C2=NC=CC(=N2)C3=C(C)N=C(C)S3i]5m۰=k}Ͽ/.kV!~jR{y}.My_e -߹^S7OSA$0e1e5007-cf6f-4b89-91d0-32ee50991de839 2.60544705 2.502638820 2.60249686 1.502643110 3.4670434 1.000090360 3.46111274-0.005036853250 4.33454418 -0.5024631620 5.20507240.0001373292330 5.20216942 1.000164270 4.33757162 1.502690790 4.33749485 -1.502458690 5.20499182 -1.999901060 3.47294855 -2.00501180 1.73500001 1.005200390 0.867499888 1.512900110 0 1.005200030000 0.867500722 -0.4975000320 1.735000493.57627869e-070 0.867501378 -1.497500060 0.0566490702 -2.082798960 -0.893861294 -1.772106050 0.365714669 -3.035416840 1.36737573 -3.038239240 1.95365357 -3.848349330 1.67869496 -2.08304334000000000 0!0"0#0$0%0&041             ! "!#"$#%$&%'&(00H00000000-0000-0000-0000-000000000000muRN);Q@Ơ?33@JQM֒T.. AJ 9.["Amino quinazoline?8eEh#. CHEMBL190636xdPD5j .XZCOCC(=O)NC1=CC2=C(C=C1)N=CN=C2NC3=CC(=CC=C3)Iy8h]1n`i|6g?_vkO _&aλ^`[}ѵs"QJ1:C/J|Gq. AJ 9.["Amino quinazoline?8eEh#. CHEMBL147232xdPD5j .XlCOC1=C(OCCN2CCCC2)C=C3N=CN=C(NC4=C(F)C=C(Cl)C=C4)C3=C1y}vl5o)U=j/m~]nzs_?=ݽ񙶳rz:soek\[m:ogooݫqWOSA$eed505cf-91fa-4030-8a94-6bc91685294751 -1.73204899-0.002535521980 -0.865292549 -0.50126719500001.37129419e-07 1.005601290 -0.8674892781.5030570 -1.73204327 1.000517130 -2.5995326 1.497972970 -3.46408653 0.9954329730 -4.38003826 1.39783680 -5.05011368 0.6555063130 -4.54814386 -0.2111125890 -3.56816483-0.003810069290 0.867900312 1.513501050 1.73580015 1.005600570 2.60120034 1.512300370 3.47350025 1.007900120 3.47480011 0.002300123220 2.60380006 -0.4988997280 2.60372448 -1.49889970 3.46971202 -1.998965140 3.47109413 -3.004164460  2.60428238 -3.502799750 4.33929157 -3.510670660 5.20609236 -3.001777890 6.07427216 -3.498027320 5.20471001 -1.996578930 4.33652687 -1.500272510 1.737099891.22368604e-070 0.867900074 -0.4976999760 1.95417714 -1.8738507000 0!0"0#0$0%0&0'0(0)0*0+0,0-0.0/000102054              !" #!$"%#&$'%(&)' *( +) ,* -+ ., /- 0.1/203142500H00000000-0000-0000-0000-000000000000muRN);Q@Ƨ?33@]SsD͗DM. AJ 9.[,2,4-diaminopyrimidines?8eEh#.CHEMBL1738742xdPD5j .XvCOC1=C(C=CC(=C1)NC2=NC(=CC=N2)NC3=CN=C4C=CC=CC4=C3)N5CCOCC5H00000000-0000-0000-0000-000000000000muRN);Q@@?33@SMZEM!q^. AJ 9.["Amino quinazoline?8eEh#. CHEMBL524059xdPD5j .X\BrC1=CC=CC(=C1)NC2=NC=NC3=CN=C(CC(=O)C=C)C=C23H00000000-0000-0000-0000-000000000000muRN);Q@@?33@sFxIK=/~Y. AJ 9.["Imidazo pyrazines?8eEh#. CHEMBL186240xdPD5j .XxCN(CCN1CCOCC1)C2=NC=C3[N]4C=NC=C4C(=NC3=C2)NC5=C(C)C=CC=C5ClH00000000-0000-0000-0000-000000000000muRN);Q@@?33@oO>JM3G. AJ 9.[64- and 4,6-aminopyrimidines?8eEh#.CHEMBL1257671xdPD5j .XzFC(F)(F)OC1=CC=C(NC2=CC(=NC=N2)C3=C[N](CC4=CC=CN=C4)N=C3)C=C1H00000000-0000-0000-0000-000000000000muRN);Q@@?33@Ԙ:YI. AJ 9.["amino non-purines?8eEh#.CHEMBL1258141xdPD5j .XrCOCCCNC(=O)CC[N]1C=CC2=C(NC3=CC=C(OC(F)(F)F)C=C3)N=CN=C12H00000000-0000-0000-0000-000000000000muRN);Q@Y?33@^T(GWϽ#(. AJ 9.["Amino quinazoline?8eEh#. CHEMBL126600xdPD5j .XbCCOC1=C(OCC)C=C2C(=NC=NC2=C1)NC3=CC(=CC=C3)C(C)=OH00000000-0000-0000-0000-000000000000muRN);Q@49`?33@vH$;x. AJ 9.["Amino quinazoline?8eEh#. CHEMBL204294xdPD5j .XhCOC1=CC(=C2C(=NC=NC2=C1)NC3=CC(=C(F)C=C3)Cl)OC4CCOC4H00000000-0000-0000-0000-000000000000muRN);Q@+?33@(kMhkMaԧ. AJ 9.["Amino quinazoline?8eEh#. CHEMBL564470xdPD5j .XrCC1=CC(=N[NH]1)NC2=NC(=NC3=CC=CC=C23)SC4=C(Cl)C(=CC=C4)ClH00000000-0000-0000-0000-000000000000muRN);Q@?33@LC3Aܟ9,o. AJ 9.[Odds?8eEh#. CHEMBL181293xdPD5j .X\FC1=C(Cl)C=C(NC2=NC=NC3=N[N]4C=CC=CC4=C23)C=C1H00000000-0000-0000-0000-000000000000muRN);Q@)?33@IE'Ot. AJ 9.[,2,4-diaminopyrimidines?8eEh#. CHEMBL209280xdPD5j .XxFC1=CC=C(C=C1)N(C(=O)NC2=C(Cl)C=CC=C2)C3=NC(=NC=C3)NC4CCOCC4H00000000-0000-0000-0000-000000000000muRN);Q@?33@ѡF{(.. AJ 9.[82-aminopyrimidine, 4-aroring?8eEh#. CHEMBL411704xdPD5j .XNC(=O)NC1=CC=C(NC2=NC=CC(=N2)C3=CC=C(C=C3)[S](=O)(=O)N4CCNCC4)C=C1H00000000-0000-0000-0000-000000000000muRN);Q@cT?33@#'[G?b,%. AJ 9.["Amino quinazoline?8eEh#. CHEMBL380946xdPD5j .XCOC1=C(CN(C)[C@@H](CN(C)C)C(N)=O)C=C2C(=NC=NC2=C1)NC3=C(F)C(=CC=C3)ClH00000000-0000-0000-0000-000000000000muRN);Q@/?33@4$Ja. AJ 9.["Amino quinazoline?8eEh#. CHEMBL356700xdPD5j .XtCOC1=C(OCCOCCN2CCOCC2)C=C3N=CN=C(NC4=C(F)C=C(Cl)C=C4)C3=C1H00000000-0000-0000-0000-000000000000muRN);Q@n?33@I8 K7w. AJ 9.["amino non-purines?8eEh#. CHEMBL123156xdPD5j .XnCOC1=CC(=CC=C1)CNC2=C3C(=NC=NC3=N[NH]2)NC4=CC(=CC=C4)ClH00000000-0000-0000-0000-000000000000muRN);Q@?33@5N5Eka6]. AJ 9.["amino non-purines?8eEh#. CHEMBL185854xdPD5j .XJCC1=C(O)C=C(NC2=NC=N[N]3C=CC=C23)C=C1H00000000-0000-0000-0000-000000000000muRN);Q@?33@FH6c. AJ 9.[Odds?8eEh#. CHEMBL474619xdPD5j .XjCOC1=CC(=CC(=C1)NC2=C(C(N)=O)C3=NN=C[N]3C(=N2)NCCN)OCH00000000-0000-0000-0000-000000000000muRN);Q@?33@Kqa"5aO&NJ>?b. AJ 9.[,2,4-diaminopyrimidines?8eEh#. CHEMBL497854xdPD5j .XfCC1=NOC(=C1)CNC2=NC(=C(Br)C=N2)NC3=N[NH]C(=C3)C4CC4H00000000-0000-0000-0000-000000000000muRN);Q@ ?33@ĤW. AJ 9.["Amino quinazoline?8eEh#.CHEMBL1081852xdPD5j .XLCC1=CC(=CC=C1)NC2=NC=NC3=CC=C(Br)C=C23H00000000-0000-0000-0000-000000000000muRN);Q@p?33@݌!@'5!{O^. AJ 9.[Aminopyrazines?8eEh#. CHEMBL178505xdPD5j .X^OCCCNC1=C(C=CN=C1)C2=CN=CC(=N2)NC3=CC=CC(=C3)ClH00000000-0000-0000-0000-000000000000muRN);Q@/?33@/]g@LsIt z. AJ 9.["Amino quinazoline?8eEh#.CHEMBL1164262xdPD5j .XCCOC(=O)C1=CC2=C(S1)C=CC(=C2)NC3=NC=NC4=CC(=C(OC)C=C34)OCCCN5CCCCC5CH00000000-0000-0000-0000-000000000000muRN);Q@/?33@ -JNsJ. AJ 9.["Amino quinazoline?8eEh#. CHEMBL127929xdPD5j .X~CCOC1=C(OCC)C=C2C(=NC(=NC2=C1)CC(C)C)NC3=CC(=CC=C3)C4=CSC(=N4)CH00000000-0000-0000-0000-000000000000muRN);Q@z?33@afYJbzW. AJ 9.[,2,4-diaminopyrimidines?8eEh#. CHEMBL192440xdPD5j .XvClC1=C(Cl)C(=CC=C1)CNC2=NC(=NC=C2Br)NC3=CC4=C([NH]C=N4)C=C3H00000000-0000-0000-0000-000000000000muRN);Q@Ơ?33@9hMNBy0. AJ 9.["Amino quinazoline?8eEh#.CHEMBL1630118xdPD5j .XONC(=O)\C=C\C1=CC=C(C=C1)C2=CC=C3N=CN=C(NC4=CC(=C(OCC5=CC=CC(=C5)F)C=C4)Cl)C3=C2H00000000-0000-0000-0000-000000000000muRN);Q@Ơ?33@ g2N'/U. AJ 9.[Odds?8eEh#. CHEMBL402910xdPD5j .XNC(=O)C1=C[N](C2=CC3=C(CCC3)C=C2)C4=NC(=NC=C4[C]1=O)NC5=CC(=CC=C5)C(=O)N6CCCCC6H00000000-0000-0000-0000-000000000000muRN);Q@Ơ?33@unT@_~w/. AJ 9.["Amino quinazoline?8eEh#. CHEMBL179511xdPD5j .XTClCCNC1=CC=C2N=CN=C(NC3=CC=CC(=C3)Cl)C2=C1H00000000-0000-0000-0000-000000000000muRN);Q@hr?33@'I"h0R. AJ 9.["Amino quinazoline?8eEh#. CHEMBL281948xdPD5j .XnC([N]1C=NC2=CC=C(NC3=NC=NC4=CC=CC=C34)C=C12)C5=CC=CC=C5H00000000-0000-0000-0000-000000000000muRN);Q@W @?33@r/@QS)%K. AJ 9.["Amino quinazoline?8eEh#. CHEMBL293113xdPD5j .XlCCN(CC)CCOC1=C(OC)C=C2N=CN=C(NC3=CC(=C(F)C=C3)Cl)C2=C1H00000000-0000-0000-0000-000000000000muRN);Q@@?33@U,+K̞g<¯. AJ 9.[,2,4-diaminopyrimidines?8eEh#. CHEMBL186396xdPD5j .XCCNC(=O)NC1=CC=C(C=C1)N(C)C2=NC(=NC=C2)NC3=CC=C(C[S](C)(=O)=O)C=C3H00000000-0000-0000-0000-000000000000muRN);Q@\)?33@yx|m@s|YAwo. AJ 9.["Amino quinazoline?8eEh#. CHEMBL329040xdPD5j .XLNC1=CC=C2C(=NC=NC2=C1)NC3=CC=CC(=C3)ClH00000000-0000-0000-0000-000000000000muRN);Q@=p?33@ȰQ7BOk. AJ 9.["Amino quinazoline?8eEh#. CHEMBL340259xdPD5j .XrCCOC1=NC(=CS1)C2=CC=CC(=C2)NC3=NC=NC4=CC(=C(OCC)C=C34)OCCH00000000-0000-0000-0000-000000000000muRN);Q@`?33@ f8G3_. AJ 9.[,2,4-diaminopyrimidines?8eEh#. CHEMBL578454xdPD5j .XZCC1=NC(=NC(=C1)NC2=CC(=CC=C2)Cl)NCC3=CC=CC=C3H00000000-0000-0000-0000-000000000000muRN);Q@?33@eW@IH1|1. AJ 9.["Amino quinazoline?8eEh#. CHEMBL272885xdPD5j .XhBrC1=C(NCCC[N]2C=CN=C2)C(=CC=C1)NC3=NC=NC4=CC=NC=C34H00000000-0000-0000-0000-000000000000muRN);Q@?33@YvQOں|Ґ. AJ 9.[Odds?8eEh#. CHEMBL281957xdPD5j .XCCN(CC)C\C=C\C1=NC(=C2C(=C1C)C=CC3=C2[N](C)C(=N3)NC4=C(Cl)C=CC=C4Cl)OH00000000-0000-0000-0000-000000000000muRN);Q@?33@X˷I߷ks"Y. AJ 9.["Amino quinazoline?8eEh#. CHEMBL126934xdPD5j .XCCOC1=C(OCC)C=C2C(=NC=NC2=C1)NC3=CC(=CC=C3)C4=CSC(=N4)CC5=CC=CC=C5H00000000-0000-0000-0000-000000000000muRN);Q@?33@/">F'? . AJ 9.[,2,4-diaminopyrimidines?8eEh#. CHEMBL575273xdPD5j .XCNC1CCN(CC1)C2=CC(=C(NC3=NC=C(Cl)C(=N3)NC4=C(C=CC=C4)[S](=O)(=O)C(C)C)C=C2)OCH00000000-0000-0000-0000-000000000000muRN);Q@?33@n-BI*:EG. AJ 9.["Amino quinazoline?8eEh#. CHEMBL127083xdPD5j .XdOCCN(CCO)CCCNC1=NC=C2C(=NC=NC2=C1)NC3=CC=CC(=C3)BrH00000000-0000-0000-0000-000000000000muRN);Q@?33@$D̳"8-Gnk. AJ 9.[Odds?8eEh#.CHEMBL1079625xdPD5j .XCC1=C(NC2=NC3=C(C=CC=C3)[N]2C4=NC=NC(=C4)N)C=C(NC(=O)C5=C(C=NC=C5)C(C)(C)C)C=C1H00000000-0000-0000-0000-000000000000muRN);Q@?33@k?1mJ 5?. AJ 9.[Odds?8eEh#. CHEMBL333382xdPD5j .XvCC1=NC(=C2C(=C1C)C=CC3=C2N=C([NH]3)NC4=C(Br)C=C(Br)C=C4Br)OoY߬=mzj\yr֧Uy⭖Q/͟WKS[aVz{Jӽoio}+HlN]h [ݮmǝAsc}cOSA$c73b5ccf-e716-457d-a9e1-4202b3ed41f639 -0.865314245 -0.50122970300003.67518737e-07 1.005600210 0.867900431 1.513400080 1.73580027 1.005599860 1.73710001-1.46016504e-070 0.867900014 -0.4977999930 0.867577076 -1.497799870 2.60379934 -0.4989004730 3.47479963 0.002199061450 3.47260022 1.005399110 2.60120034 1.512399440 2.81400061 2.497598890 3.81700063 2.599898820 4.22400045 1.677498820 4.31977415 3.464316840 3.82255292 4.331940650 4.32408762 5.197114940# 5.32407665 5.192458630 3.83063269 6.066922190 2.82544351 6.071602820# 2.33204603 6.941406730 2.31370926 5.206476690 2.81736374 4.336621760# 2.31588626 3.471451040 0.86790067 2.513400080 4.95709085 1.519135950 5.06977034 3.461912630 0.218381718 2.888400320000 0!0"0#0$0%0&042               !" #!$"%#&$ '%(&)00H00000000-0000-0000-0000-000000000000muRN);Q@?33@(DJfz6. AJ 9.["Amino quinazoline?8eEh#. CHEMBL127852xdPD5j .XjCOC1=C(OC)C=C2C(=NC=NC2=C1)NC3=CC=CC(=C3)C4=CSC(=N4)CH00000000-0000-0000-0000-000000000000muRN);Q@?33@XWFvNVe. AJ 9.["Amino quinazoline?8eEh#. CHEMBL126788xdPD5j .XvCCOC1=C(OCC)C=C2C(=NC=NC2=C1)NC3=C(Cl)C=CC(=C3)C4=CSC(=N4)CH00000000-0000-0000-0000-000000000000muRN);Q@?33@Bf`IZZ. AJ 9.[64- and 4,6-aminopyrimidines?8eEh#. CHEMBL204555xdPD5j .X~OCC1=CC=CC(=N1)C#CC2=CN=CN=C2NC3=CC(=C(OCC4=CC=CC(=C4)F)C=C3)ClH00000000-0000-0000-0000-000000000000muRN);Q@?33@*%f0Ht'! . AJ 9.["Amino quinazoline?8eEh#. CHEMBL279093xdPD5j .XvCOC1=C(OCCCN2CCN(C)CC2)C=C3N=CN=C(NC4=C(F)C=C(Br)C=C4)C3=C1H00000000-0000-0000-0000-000000000000muRN);Q@ ?33@>wI]k:q. AJ 9.["Amino quinazoline?8eEh#. CHEMBL16294xdPD5j .XTCC(C)(C)NC1=NC(=NC2=CC=CC=C12)NC3=CC=CC=C3H00000000-0000-0000-0000-000000000000muRN);Q@@?33@Ҷ|N>#s. AJ 9.["Amino quinazoline?8eEh#.CHEMBL1630115xdPD5j .XNC1=C(NC(=O)C2=CC=C(S2)C3=CC4=C(C=C3)N=CN=C4NC5=CC(=C(OCC6=CC(=CC=C6)F)C=C5)Cl)C=CC=C1H00000000-0000-0000-0000-000000000000muRN);Q@?33@=@ O. AJ 9.["Amino quinazoline?8eEh#. CHEMBL178268xdPD5j .X`CC1=N[NH]C(=N1)NC2=NC(=NC3=CC=CC=C23)C4=CC=CC=C4H00000000-0000-0000-0000-000000000000muRN);Q@?33@, HmzTW^. AJ 9.["Amino quinazoline?8eEh#. CHEMBL51709xdPD5j .XLFC1=NC=C2C(=NC=NC2=C1)NC3=CC=CC(=C3)BrH00000000-0000-0000-0000-000000000000muRN);Q@n?33@&FZZxnD,kj8. AJ 9.["Amino quinazoline?8eEh#.CHEMBL1630116xdPD5j .XONC(=O)\C=C\C1=CC=C(O1)C2=CC=C3N=CN=C(NC4=CC(=C(OCC5=CC=CC(=C5)F)C=C4)Cl)C3=C2}ww7;~}k[_/sy>Xo۟>;ߺ;vr9la}{JwoW OSA$02ddf290-5e65-4e99-af6e-cafc1b0d6ae858 -6.6034894 -2.160898450 -5.60862541 -2.262117620 -5.02353477 -1.45114970 -5.4333086 -0.5389624830 -4.02867079 -1.552369120 -3.44358015 -0.7414010760 -2.44871616 -0.8426204320 -1.94849789 -1.7085520 -0.969488978 -1.497498040 -0.865292549 -0.5012671950 -1.78407121 -0.09486185760 000 1.37129419e-07 1.005601290 0.867900312 1.513501050 1.73580015 1.005600570 2.60120034 1.512300370 3.47350025 1.007900120 3.47480011 0.002300123220 2.60380006 -0.4988997280 2.60372448 -1.49889970 3.46971202 -1.998965140 3.46667123 -3.004105330 4.34152889 -3.499018670 5.21060896 -2.99391770 6.07878971 -3.490165950 6.94264364 -2.986423490 7.81082439 -3.482671980 7.81220818 -4.487871650 8.68039227 -4.984176640 9.54720688 -4.485482690 9.5458231 -3.48028350 8.6776247 -2.973778250 10.4126339 -2.981647250! 5.20483112 -1.993903280" 4.33879232 -1.49386430# 4.34735441 -4.49900150$ 1.737099891.22368604e-070% 0.867900074 -0.4976999760& -7.04230738 -2.769124510' -5.30129528 -2.946258070( 1.95417714 -1.87385070)0*0+0,0-0.0/00010203040506070809062       %     $" !"# $!%!"&#'$($%)&*'+(,)-*.+/,0- 1. 2/30415263748596:7!;8"<9%=00H00000000-0000-0000-0000-000000000000muRN);Q@j?33@`Xp@^f<. AJ 9.["Amino quinazoline?8eEh#. CHEMBL124620xdPD5j .XJNC1=CC=CC(=C1)NC2=NC=NC3=CC(=NC=C23)NH00000000-0000-0000-0000-000000000000muRN);Q@KƠ?33@?qYL7O<-y. AJ 9.["Amino quinazoline?8eEh#. CHEMBL341110xdPD5j .XRCN(C)C1=CC=C(NC2=NC=NC3=CC(=NC=C23)N)C=C1H00000000-0000-0000-0000-000000000000muRN);Q@,@?33@OdRM{A*. AJ 9.["amino non-purines?8eEh#. CHEMBL122040xdPD5j .XjOC1=CC(=CC=C1)NC2=C3C(=NC=NC3=N[NH]2)NC4=CC(=CC=C4)ClH00000000-0000-0000-0000-000000000000muRN);Q@@?33@,5SGYb . AJ 9.["Amino quinazoline?8eEh#. CHEMBL341035xdPD5j .XCCOC1=C(OCC)C=C2C(=NC(=NC2=C1)C(F)(F)F)NC3=CC(=CC=C3)C4=CSC(=N4)CH00000000-0000-0000-0000-000000000000muRN);Q@l?33@CդmLuR4. AJ 9.["Amino quinazoline?8eEh#.CHEMBL1630113xdPD5j .XONC(=O)\C=C\C1=CC=C(S1)C2=CC=C3N=CN=C(NC4=CC(=C(OCC5=CC=CC(=C5)F)C=C4)Cl)C3=C2}www~i_{_u{Zxo߿+)+nϝo۶oww}U OSA$5f82859f-ac07-451f-b14f-19b98b63106f58 -6.6034894 -2.160898450 -5.60862541 -2.262117620 -5.02353477 -1.45114970 -5.4333086 -0.5389624830 -4.02867079 -1.552369120 -3.44358015 -0.7414010760 -2.44871616 -0.8426204320 -1.94849789 -1.7085520 -0.969488978 -1.497498040 -0.865292549 -0.5012671950 -1.78407121 -0.09486185760 000 1.37129419e-07 1.005601290 0.867900312 1.513501050 1.73580015 1.005600570 2.60120034 1.512300370 3.47350025 1.007900120 3.47480011 0.002300123220 2.60380006 -0.4988997280 2.60372448 -1.49889970 3.46971202 -1.998965140 3.46667123 -3.004105330 4.34152889 -3.499018670 5.21060896 -2.99391770 6.07878971 -3.490165950 6.94264364 -2.986423490 7.81082439 -3.482671980 7.81220818 -4.487871650 8.68039227 -4.984176640 9.54720688 -4.485482690 9.5458231 -3.48028350 8.6776247 -2.973778250 10.4126339 -2.981647250! 5.20483112 -1.993903280" 4.33879232 -1.49386430# 4.34735441 -4.49900150$ 1.737099891.22368604e-070% 0.867900074 -0.4976999760& -7.04230738 -2.769124510' -5.30129528 -2.946258070( 1.95417714 -1.87385070)0*0+0,0-0.0/00010203040506070809062       %     $" !"# $!%!"&#'$($%)&*'+(,)-*.+/,0- 1. 2/30415263748596:7!;8"<9%=00H00000000-0000-0000-0000-000000000000muRN);Q@M?33@`ԲG>g. AJ 9.["Amino quinazoline?8eEh#. CHEMBL258404xdPD5j .XCN1CCN(CC1)C(=O)COC2=C3C(=NC=NC3=CC=C2)NC4=CC(=C(OCC5=NC=CC=C5)C=C4)ClH00000000-0000-0000-0000-000000000000muRN);Q@Ơ?33@LD&TH. AJ 9.["Amino quinazoline?8eEh#. CHEMBL430606xdPD5j .XrC=CC(=O)NC1=CC2=C(C=C1)N=CN=C2NC3=CC=C(OCC4=CC=CC=C4)C=C3H00000000-0000-0000-0000-000000000000muRN);Q@š?33@"^?@_FXCo. AJ 9.[Amino purines?8eEh#. CHEMBL133498xdPD5j .XjCCCCNC1=NC(=NC2=C1N=C[N]2C(C)C)C#CC(C)(O)CC3=CC=CC=C3H00000000-0000-0000-0000-000000000000muRN);Q@9`?33@`IKU. AJ 9.["Amino quinazoline?8eEh#. CHEMBL203714xdPD5j .XrFC1=CC=C(NC2=NC=NC3=CN=C(NC(=O)C#CCCN4CCOCC4)C=C23)C=C1ClH00000000-0000-0000-0000-000000000000muRN);Q@9`?33@nIG(. AJ 9.["Amino quinazoline?8eEh#. CHEMBL338355xdPD5j .XxCCOC1=C(OCC)C=C2C(=NC(=NC2=C1)CCN)NC3=CC(=CC=C3)C4=CSC(=N4)C9}7ogs_|{>gq_3:zo{u~OߕkO[m3d_}^] OSA$c00161f2-b5a2-4a2f-87db-3d923f42971159 -2.59953308 1.497969510 -1.73204327 1.000514510 -0.867489696 1.503055100 1.005599980000 -0.865292609 -0.5012671350 -0.863828897 -1.5012660 -1.72912157 -2.002532960 0.867900729 -0.4977004830 1.73710048 2.0428665e-080 2.60380077 -0.4988996680 3.47480059 0.002300684110 3.47350001 1.007900710 2.60119987 1.512300490 1.73580003 1.005600090 0.867900014 1.513500090 4.33936882 1.508171560 4.33905602 2.508171560 5.20492506 3.00844240 2.60372519 -1.498899820 3.46971297 -1.998965260 3.46667242 -3.004105810 4.34153032 -3.499019150 5.21061039 -2.993917940 5.20483255 -1.99390340 4.33879328 -1.49386430 4.34735584 -4.499002460 5.15903187 -5.083159450 4.86005545 -6.037889480 3.85542893 -6.044602390 3.54135656 -5.093449590 3.2722857 -6.856971740 5.20469046 3.75844240! 5.85456133 2.63364530" 1.95417774 -1.873850820#0$0%0&0'0(0)0*0+0,0-0.0/000102030405060708090:062               !" #!$"%#&$'%(&)'*(+),*-+.,/-0.1/2031425364758697:8;9<:=00H00000000-0000-0000-0000-000000000000muRN);Q@6E?33@OCr?MN/. AJ 9.[,2,4-diaminopyrimidines?8eEh#.CHEMBL1643233xdPD5j .XCC1=CC=C(NC2=NC(=NC(=C2)NC3=CC=C(N[S](=O)(=O)C4=C(F)C=CC=C4)C=C3)C)C=C1H00000000-0000-0000-0000-000000000000muRN);Q@6E?33@76M*Awh. AJ 9.["Amino quinazoline?8eEh#. CHEMBL129009xdPD5j .X`BrC1=CC(=CC=C1)NC2=NC=NC3=CC(=NC=C23)NCCN4CCOCC4H00000000-0000-0000-0000-000000000000muRN);Q@49`?33@T!&KNs . AJ 9.[82-aminopyrimidine, 4-aroring?8eEh#. CHEMBL584366xdPD5j .X\NCCNC1=NC=CC(=C1)C2=CC=NC(=N2)NC3=CC=CC(=C3)ClH00000000-0000-0000-0000-000000000000muRN);Q@@?33@_$v.D4!<" a. AJ 9.[Odds?8eEh#.CHEMBL1087566xdPD5j .XCOC1=CC(=NC=N1)[N]2C(=NC3=C2C=CC=C3)NC4=C(C)C=CC(=C4)NC(=O)C5=CC(=CC=C5)C(F)(F)FH00000000-0000-0000-0000-000000000000muRN);Q@ 7@?33@y~G NyuK. AJ 9.["Amino quinazoline?8eEh#.CHEMBL1164353xdPD5j .XCCOC(=O)C1=CC2=C(S1)C=CC(=C2)NC3=NC=NC4=CC(=C(OC)C=C34)OCCCN(C)CH00000000-0000-0000-0000-000000000000muRN);Q@?33@W\•HEAU. AJ 9.["Amino quinazoline?8eEh#. CHEMBL190664xdPD5j .XjCOCC(=O)NC1=CC2=C(C=C1)N=CN=C2NC3=C(F)C=C(Cl)C(=C3)ClH00000000-0000-0000-0000-000000000000muRN);Q@49`?33@L28G݄. AJ 9.["Amino quinazoline?8eEh#. CHEMBL31574xdPD5j .XpCOCCOC1=C(NC(=O)C=C)N=C2C(=NC=NC2=C1)NC3=CC(=C(F)C=C3)Cl{kw~?g{ߵ{~wo]~߯yk߫cOSA$64228f1a-f02c-4545-9265-2e067c383ebf46 4.33136845 -1.506208060 3.46540165 -1.00610650 2.59931755 -1.506004930 1.73335087 -1.005903240 0.867266834 -1.505801680 0.0013000964 -1.005699990000 0.865890741 0.5002332330 0.865621448 1.500233170 -0.000538706779 1.999999760 1.73151231 2.000466350 1.7312429 3.000466350 -0.872299969 0.5044991970 -1.73770022-0.002200482650 -2.60560012 0.5055997370 -3.47350025-0.002200126650 -3.47350025 -1.007900120 -2.60560012 -1.505700110 -1.73640001 -1.007900120 -0.869699955 -1.506800060 -2.60560012 1.505599740 -3.47162533 2.005599980 -3.46865988 3.010740280 -4.34355497 3.505587820 -5.21259689 3.000421290  -6.08081484 3.49660420 -5.20674372 2.000407220 -4.34066725 1.500433560 -4.34945583 4.505570410 1.5155108 0.1254082020 -1.95608103 1.8805997400 0!0"0#0$0%0&0'0(0)0*0+0,0-048            ! "!#"$#%$&%'& (' )( *)+*,+-,.-/00H00000000-0000-0000-0000-000000000000muRN);Q@49`?33@2h'-|GO1uݼ. AJ 9.["Amino quinazoline?8eEh#. CHEMBL193167xdPD5j .XZClCC(=O)NC1=CC=C2N=CN=C(NC3=CC=CC(=C3)I)C2=C1H00000000-0000-0000-0000-000000000000muRN);Q@49`?33@cKHՙw. AJ 9.[Amino purines?8eEh#. CHEMBL90826xdPD5j .XCOC1=CC=C(CNC2=NC(=NC3=C2N=C[N]3CC4=CC=C(C=C4)C5=CC=CC=C5)Cl)C=C1H00000000-0000-0000-0000-000000000000muRN);Q@49`?33@ICa{. AJ 9.["Amino quinazoline?8eEh#. CHEMBL190096xdPD5j .XzCN(C)C\C=C\C(=O)NC1=CC2=C(C=C1)N=CN=C2NC3=C(F)C=C(Cl)C(=C3)ClH00000000-0000-0000-0000-000000000000muRN);Q@49`?33@`GɀD<. AJ 9.[Amino purines?8eEh#. CHEMBL539688xdPD5j .XpCC(C)[N]1C=NC2=C(NC3CC4=C(C3)C=CC=C4)N=C(N=C12)N(CCO)CCOH00000000-0000-0000-0000-000000000000muRN);Q@49`?33@}}bDKJ\7. AJ 9.["Amino quinazoline?8eEh#. CHEMBL329676xdPD5j .XFClC1=CC=CC(=C1)NC2=NC=NC3=C2C=CC=C3H00000000-0000-0000-0000-000000000000muRN);Q@49`?33@sj JP . AJ 9.[Amino purines?8eEh#. CHEMBL90696xdPD5j .XhCC(C)[N]1C=NC2=C(NCCCC3=CC=CC=C3)N=C(N=C12)N(CCO)CCOH00000000-0000-0000-0000-000000000000muRN);Q@49`?33@.l ;I E>>. AJ 9.["Amino quinazoline?8eEh#. CHEMBL328701xdPD5j .XZCOC(=O)NC1=CC2=C(C=C1)N=CN=C2NC3=CC(=CC=C3)BrH00000000-0000-0000-0000-000000000000muRN);Q@49`?33@MFA|5$w. AJ 9.[Amino purines?8eEh#. CHEMBL89964xdPD5j .XxCC(C)[N]1C=NC2=C(NC3=CC=C(Br)C=C3)N=C(NC4=CC=C(Br)C=C4)N=C12H00000000-0000-0000-0000-000000000000muRN);Q@49`?33@hB)uo. AJ 9.["Amino quinazoline?8eEh#. CHEMBL214475xdPD5j .X|COC1=C(OC2CCN(CC2)CC(N)=O)C=C3C(=NC=NC3=C1)NC4=C(F)C=CC(=C4)ClH00000000-0000-0000-0000-000000000000muRN);Q@T?33@WBL+rۦ(. AJ 9.[Odds?8eEh#. CHEMBL203024xdPD5j .XxCCOC1=C(NC2=NC=CC(=C2)C3=CC(=NC=C3)NC4=C(OCC)C=CC=C4)C=CC=C1H00000000-0000-0000-0000-000000000000muRN);Q@X`?33@@=pKt PW=. AJ 9.["Amino quinazoline?8eEh#. CHEMBL597839xdPD5j .XnCOC1=C(OCCCC(=O)NO)C=C2C(=NC=NC2=C1)NC3=CC(=C(F)C=C3)ClH00000000-0000-0000-0000-000000000000muRN);Q@?33@H0(ռ$. AJ 9.["Amino quinazoline?8eEh#. CHEMBL126405xdPD5j .X~CCOC1=C(OCC)C=C2C(=NC(=NC2=C1)CN(C)C)NC3=CC(=CC=C3)C4=CSC(=N4)CH00000000-0000-0000-0000-000000000000muRN);Q@?33@ٌ/ CgQ-{. AJ 9.[Odds?8eEh#. CHEMBL215072xdPD5j .XfCOC1=C(OC)C=C2NC3=NC=NC(=C3NCC2=C1)NC4=CC(=CC=C4)BrH00000000-0000-0000-0000-000000000000muRN);Q@KƠ?33@]s"CK]e. AJ 9.["Amino quinazoline?8eEh#. CHEMBL402453xdPD5j .XFNC1=C(O)C=CC=C1NC2=NC=NC3=CC=NC=C23 >Yt|-3g k}Xh2Wh'E܆nA@J9LRS VPJ0_|HicLeSl Bxyp5ςߜ,AUOSA$ef93ff1b-d909-436b-bb28-35167b38a67730 -0.883121312 4.517879490 -0.0172355138 4.017637730 0.856334448 4.514820580 0.859563828 5.514815330 1.72672284 4.011977670 1.72354126 3.011951450 0.858803332 2.509665730 -0.011585176 3.012508630 -0.876271605 2.510196690 -0.873599946 1.510200140 -0.0013000964 1.005699990 000 -0.871000409 -0.5011002420 -1.73770022-0.002199915470 -2.60690045 -0.4999994640 -3.47480035-0.002199172970 -3.47479987 1.003500820 -2.60689974 1.511300680 -1.73900008 1.003500340 -0.882912099 5.267879490 -1.53274488 4.143060680 1.51029038 5.887715820 -1.52679026 2.883460040000000032             00H00000000-0000-0000-0000-000000000000muRN);Q@KƠ?33@4 AiP0Ҳ. AJ 9.["Amino quinazoline?8eEh#. CHEMBL526639xdPD5j .XCC1=CC(=CC=C1)[N]2N=C(C=C2NC(=O)NC3=CC(=CC=C3)NC4=NC=NC5=CC=C(C=C45)[N](=O)=O)C(C)(C)CH00000000-0000-0000-0000-000000000000muRN);Q@Ơ?33@@2^N3!?. AJ 9.[Aminopyrazines?8eEh#. CHEMBL199383xdPD5j .XfCC(=O)NC1=CC(=CC=C1)C2=NC(=CN=C2)NC3=CC(=CC=C3)OCCNH00000000-0000-0000-0000-000000000000muRN);Q@Ơ?33@7OI 7@]. AJ 9.["Amino quinazoline?8eEh#. CHEMBL93353xdPD5j .XVCOC1=C(OC)C2=NC=NC(=C2C=C1)NC3=CC(=CC=C3)Bryfh5o(zd,ėw7W'E߆.'~ɍn9ZRS5޷3V=*|AkckHHm5rЫ*SmdSlY`^9O뤱QUuOSA$2dd74f47-fa6a-4b99-a3c0-65d1b9b71c4e36 -0.870424747 2.503052710 -0.8674892781.50305701.37129419e-07 1.005601290 0.867900312 1.513501050 0.86790067 2.513501170 0.00187546015 3.013501640 1.73580015 1.005600570 2.60120034 1.512300370 3.47350025 1.007900120 3.47480011 0.002300123220 2.60380006 -0.4988997280 1.737099891.22368604e-070 0.867900074 -0.4976999760 000 2.60372448 -1.49889970 3.46971202 -1.998965140 3.46667123 -3.004105330 4.34152889 -3.499018670 5.21060896 -2.99391770 5.20483112 -1.993903280 4.33879232 -1.49386430# 4.34735441 -4.49900150 1.95417714 -1.87385070000000000 0!0"0#038                ! "!#"$#%00H00000000-0000-0000-0000-000000000000muRN);Q@Ơ?33@ygN垿s0m. AJ 9.[Odds?8eEh#. CHEMBL319467xdPD5j .XtN[S](=O)(=O)C1=CC=C(NC2=NC(=C3N=C[NH]C3=N2)OCC4CCCCC4)C=C1H00000000-0000-0000-0000-000000000000muRN);Q@E?33@v$+aOܞPbk. AJ 9.["Amino quinazoline?8eEh#. CHEMBL364623xdPD5j .XCOC1=C(OC)C=C2C(=NC=NC2=C1)NC3=C(C)C=CC(=C3)NC(=O)C4=CC(=CC=C4)N(C)CH00000000-0000-0000-0000-000000000000muRN);Q@hr?33@cjfD#ls\CϿ>. AJ 9.[,2,4-diaminopyrimidines?8eEh#. CHEMBL214475xdPD5j .XxCN1CCN(CC1)C2=CC=C(NC3=NC(=C(C=N3)C(=O)C4=CC(=CC=C4)F)N)C=C2H00000000-0000-0000-0000-000000000000muRN);Q@+?33@xK\q. AJ 9.["Amino quinazoline?8eEh#. CHEMBL271564xdPD5j .XXCN(C)CCCCNC1=C(C)C=CC=C1NC2=NC=NC3=CC=NC=C23H00000000-0000-0000-0000-000000000000muRN);Q@ ?33@ă2M9ރ . AJ 9.["Amino quinazoline?8eEh#. CHEMBL215205xdPD5j .XCCN(CCO)CCCOC1=CC2=NC=NC(=C2C=C1)NC3=N[NH]C(=C3)CC(=O)NC4=CC(=CC=C4)FH00000000-0000-0000-0000-000000000000muRN);Q@ ?33@;ğAe{. AJ 9.["Amino quinazoline?8eEh#. CHEMBL216673xdPD5j .X~COC1=CC(=C(Cl)C=C1)NC2=NC=NC3=C2C(=CC(=C3)OCCCN4CCOCC4)OC5CCOC5H00000000-0000-0000-0000-000000000000muRN);Q@$ ?33@NpDuEI. AJ 9.[Amino purines?8eEh#. CHEMBL83719xdPD5j .XlCC(C)[N]1C=NC2=C(NC34CC5CC(CC(C5)C3)C4)N=C(NCCCO)N=C12H00000000-0000-0000-0000-000000000000muRN);Q@?33@xCrM. AJ 9.[64- and 4,6-aminopyrimidines?8eEh#. CHEMBL383172xdPD5j .XpCC1=C(NC2=NC=NC(=C2C#N)NC3CCCC3)C=C(C=C1)C(=O)NC4=NOC=C4H00000000-0000-0000-0000-000000000000muRN);Q@?33@h-$KphLr. AJ 9.["Amino quinazoline?8eEh#. CHEMBL258391xdPD5j .XCN(CCO)C(=O)COC1=C2C(=NC=NC2=CC=C1)NC3=CC(=C(OCC4=NC=CC=C4)C=C3)ClH00000000-0000-0000-0000-000000000000muRN);Q@?33@a RDLף;. AJ 9.["Amino quinazoline?8eEh#. CHEMBL270945xdPD5j .XFNC1=C(F)C=CC=C1NC2=NC=NC3=CC=NC=C23 0?0@0A0B0C0D0E075     "         !"#$ % !&!"'#($)%*&+',(-).*/+0,1-2.3/405162 73 84 95 :6;7<8=9>:?;@<A=B>C?D@EAFBGCHD!IE"J00H00000000-0000-0000-0000-000000000000muRN);Q@!?33@Vk@za)5. AJ 9.[,Pyrimidinyl quinolones?8eEh#. CHEMBL192126xdPD5j .XrO=[C]1C=CC2=C(N=C(NC3=NC=C(C=C3)N4CCNCC4)N=C2)[N]1C5CCCC5H00000000-0000-0000-0000-000000000000muRN);Q@z?33@g8H٭獤#. AJ 9.[,Pyrimidinyl quinolones?8eEh#. CHEMBL180715xdPD5j .XxCOC1=C(C(=CC=C1)OC)C2=CC3=CN=C(NC4=CC=CC=C4)N=C3[N](C)[C]2=OH00000000-0000-0000-0000-000000000000muRN);Q@@?33@l0D{FRB. AJ 9.[,Pyrimidinyl quinolones?8eEh#. CHEMBL183455xdPD5j .XXCOC1=C(C2CCCC2)C3=NC(=NC=C3C=C1)NC4=CC=CC=C4H00000000-0000-0000-0000-000000000000muRN);Q@Ǯ ?33@4 +/@VpM. AJ 9.[,Pyrimidinyl quinolones?8eEh#. CHEMBL139653xdPD5j .XZCCOCC[N]1[C](=O)C=CC2=CN=C(NC3=CC=CC=C3)N=C12H00000000-0000-0000-0000-000000000000muRN);Q@Q?33@ȴTF0zmO. AJ 9.[,Pyrimidinyl quinolones?8eEh#. CHEMBL190091xdPD5j .XCCOC(=O)C1=C(C)C2=C(N=C(NC3=CC=C(C=C3)N4CCNCC4)N=C2)[N](C5CCCC5)[C]1=OH00000000-0000-0000-0000-000000000000muRN);Q@O?33@59NJ)_]H. AJ 9.[,Pyrimidinyl quinolones?8eEh#. CHEMBL143491xdPD5j .X`O=[C]1C=CC2=C(N=C(NC3=CC=CC=C3)N=C2)[N]1C4CCCCC4H00000000-0000-0000-0000-000000000000muRN);Q@}?33@Eo@FKq|. AJ 9.[,Pyrimidinyl quinolones?8eEh#. CHEMBL181834xdPD5j .XbCOC1=CC=C2C=NC(=NC2=C1C(C)C)NC3=CC=C(C=C3)N4CCCC4H00000000-0000-0000-0000-000000000000muRN);Q@N ?33@JDFJѼ`H̭.. AJ 9.[,Pyrimidinyl quinolones?8eEh#. CHEMBL361987xdPD5j .XlOC1=CC=C2C=NC(=NC2=C1C3CCCC3)NC4=CC=C(N5CCNCC5)C(=C4)FH00000000-0000-0000-0000-000000000000muRN);Q@F?33@L='P{BR4. AJ 9.[,Pyrimidinyl quinolones?8eEh#. CHEMBL190317xdPD5j .X|CC1=C[C](=O)[N](C2CCCC2)C3=C1C=NC(=N3)NC4=CC=C(C=C4)N5CCC(N)C5H00000000-0000-0000-0000-000000000000muRN);Q@ 7@?33@NIɧʑ\. AJ 9.[,Pyrimidinyl quinolones?8eEh#. CHEMBL361621xdPD5j .XCOC1=CC(=C(Cl)C(=C1Cl)C2=CC3=CN=C(NC4=CC=CC=C4)N=C3[N](C)[C]2=O)OCH00000000-0000-0000-0000-000000000000muRN);Q@I?33@8;9WBjR€zr. AJ 9.[,Pyrimidinyl quinolones?8eEh#. CHEMBL190323xdPD5j .XzBrC1=CC2=C(N=C(NC3=CC=C(C=C3)N4CCNCC4)N=C2)[N](C5CCCC5)[C]1=OH00000000-0000-0000-0000-000000000000muRN);Q@m`?33@IDnFDž{_$. AJ 9.[,Pyrimidinyl quinolones?8eEh#. CHEMBL190460xdPD5j .X~CC1=C(I)[C](=O)[N](C2CCCC2)C3=C1C=NC(=N3)NC4=CC=C(C=C4)N5CCNCC5H00000000-0000-0000-0000-000000000000muRN);Q@j?33@@[H> p& . AJ 9.[,Pyrimidinyl quinolones?8eEh#. CHEMBL574148xdPD5j .X~C[N]1[C](=O)C(=CC2=CN=C(NC3=CC=C(F)C=C3)N=C12)C4=C(Cl)C=CC=C4ClH00000000-0000-0000-0000-000000000000muRN);Q@49`?33@Gߵ2`@0. AJ 9.[,Pyrimidinyl quinolones?8eEh#. CHEMBL107530xdPD5j .XCCN(CC)CCCOC1=CC=C(NC2=NC=C3C=C([C](=O)[N](C)C3=C2)C4=C(Cl)C=CC=C4Cl)C=C1H00000000-0000-0000-0000-000000000000muRN);Q@49`?33@qF^. AJ 9.[,Pyrimidinyl quinolones?8eEh#. CHEMBL359738xdPD5j .XPCOC1=CC=C2C=NC(=NC2=C1C(C)C)NC3=CC=CC=C3H00000000-0000-0000-0000-000000000000muRN);Q@ @?33@N-H.FB|. AJ 9.[,Pyrimidinyl quinolones?8eEh#. CHEMBL181281xdPD5j .XtCOC1=CC=CC(=C1C2=CC3=CN=C(NC4=CC=CC=C4)N=C3[N](C)[C]2=O)ClH00000000-0000-0000-0000-000000000000muRN);Q@$?33@Krt5. AJ 9.[,Pyrimidinyl quinolones?8eEh#. CHEMBL182325xdPD5j .XtCOC1=CC=C2C=NC(=NC2=C1C(C)C)NC3=CC=C(C=C3)N4CCN(CC4)C(C)=O;yu5|0{\r7ViHy$'Vr_pןwU^:c+;^:ek=JK6_+57g؟m.Y} OSA$d1f6bc96-8c32-4828-9e20-188de97084d060 -0.870425761 2.50305080 -0.867489696 1.503055100 1.005599980000 0.867900729 -0.4977004830 1.73710048 2.0428665e-080 2.60380077 -0.4988996680 3.47480059 0.002300684110 3.47350001 1.007900710 2.60119987 1.512300490 1.73580003 1.005600090 0.867900014 1.513500090 0.867899776 2.513500210 0.00187426805 3.013499980 1.7339251 3.013500210 4.33936882 1.508171560 4.33905602 2.508171560 3.46689177 3.007928610 3.46653104 4.007959840 4.32948446 4.513305190 5.20164871 4.013548370 5.2108593 3.008445980 4.32477045 5.513294220 5.18986702 6.025078770 5.18512774 7.030267720 4.31529188 7.52367210 3.45014715 7.022087570 3.45488644 6.016898630 4.31057692 8.523660660 3.44220352 9.019572260 5.17423534 9.027738570 4.98900509 1.133374690 0!0"0#0$0%0&0'0(0)0*0+0,0-0.0/000102030405060708090:0;063             !" #!$"%#&$'%(& )' *( +) ,*-+.,/-0.1/2031425364758697:8;9<:=;>00H00000000-0000-0000-0000-000000000000muRN);Q@/?33@ၜrJ4"Ej. AJ 9.[,Pyrimidinyl quinolones?8eEh#. CHEMBL191845xdPD5j .XCC1=C[C](=O)[N](C2CCCC2)C3=C1C=NC(=N3)NC4=CC=C(C=C4)N5CCN(CCO)CC5H00000000-0000-0000-0000-000000000000muRN);Q@?33@.0KyŅLP. AJ 9.[,Pyrimidinyl quinolones?8eEh#. CHEMBL180797xdPD5j .XzC[N]1[C](=O)C(=C(C)C2=C1N=C(NC3=CC=CC=C3)N=C2)C4=C(C)C=CC=C4CH00000000-0000-0000-0000-000000000000muRN);Q@?33@6cL%K涅;TU. AJ 9.[,Pyrimidinyl quinolones?8eEh#. CHEMBL181013xdPD5j .XNCC(C)C1=C2N=C(NC3=CC=CC=C3)N=CC2=CC=C1OH00000000-0000-0000-0000-000000000000muRN);Q@+?33@6=D?@O. AJ 9.[,Pyrimidinyl quinolones?8eEh#. CHEMBL181791xdPD5j .XC[N]1[C](=O)C(=CC2=CN=C(NC3=CC=CC=C3)N=C12)C4=C(Cl)C(=CC=C4Cl)CNH00000000-0000-0000-0000-000000000000muRN);Q@E?33@ʡRKO޹I;". AJ 9.[,Pyrimidinyl quinolones?8eEh#. CHEMBL192060xdPD5j .XCC1=C[C](=O)[N](C2CCCC2)C3=C1C=NC(=N3)NC4=CC(=C(C=C4)N5CCNCC5)Cl{3v{6_ZhfYvyۼ+};c->_>o~ߟ[ OSA$7c4f9768-cfbe-4ac7-b410-16e01ad9509b58C1 3.7320509 2.539854050C2 3.7320509 1.539854050C3 2.86602545 1.039854050C4 2.86602545 0.03985404220O52 -0.460145950N6 3.7320509 -0.460145950C7 3.7320509 -1.460145950C8 2.92303371 -2.047931190C9 3.2320509 -2.998987670 C10 4.2320509 -2.998987670 C11 4.5410676 -2.047931190 C12 4.59807634 0.03985404220 C13 4.59807634 1.039854050 C14 5.49201822 1.574515340N15 6.39808512 1.060669420C16 6.39808512 0.01903862130N17 5.49201822 -0.4948072430N18 7.26217651 -0.4842957560C19 8.13012314 0.01236241780C20 8.13397789 1.012354970C21 9.00192356 1.509013180C22 9.86601543 1.005678770C23 9.86216068 0.005686215590C24 8.99421501 -0.4909719820N25 10.7339621 1.502336980C26 11.598053 0.9990025760C27 12.4659996 1.495660780N28 12.4698544 2.495653390C29 11.6057625 2.998987670C30 10.7378159 2.502329590Cl31 9.00577831 2.509005780H32 4.35205078 2.539854050 H33 3.7320509 3.159853940!H34 3.11205101 2.539854050"H35 2.32908964 1.349854110#H36 4.28447485 -1.178671840$H37 2.61303377 -1.510995390%H38 2.35663557 -2.300107960&H39 2.62559938 -3.127892970'H40 3.29685855 -3.615591290(H41 4.16724348 -3.615591290)H42 4.83850241 -3.127892730*H43 5.10746574 -2.300107960+H44 4.85106754 -1.510995510,H45 5.48484898 2.194473980-H46 7.25978708 -1.10429120.H47 7.59824085 1.324422240/H48 10.3978977 -0.30638107700H49 8.9918251 -1.110967401H50 11.1976967 0.52559483102H51 11.9947472 0.5225223303H52 12.6758051 0.912238304H53 13.0769911 1.6009682405H54 13.0079803 2.8035814806H55 12.0061188 3.4723956607H56 11.2090683 3.4754679208H57 10.5280104 3.0857520109H58 10.1268244 2.39702177062               !"# $!%"&#'$(%)&*'+ (, )- *. +/ ,0-1.2/30415263748596:7;8<9=0H00000000-0000-0000-0000-000000000000muRN);Q@hr?33@H6J,Rx. AJ 9.[,Pyrimidinyl quinolones?8eEh#. CHEMBL181523xdPD5j .X~C[N]1[C](=O)C(=CC2=CN=C(NC3=CC=CC=C3)N=C12)C4=C(Cl)C(=CC=C4Cl)NH00000000-0000-0000-0000-000000000000muRN);Q@-`?33@#/7-Dyw>'. AJ 9.[,Pyrimidinyl quinolones?8eEh#. CHEMBL360675xdPD5j .X~C[N]1[C](=O)C(=CC2=C1N=C(NC3=CC=CC=C3)N=C2)C4=C(Cl)C=CC(=C4Cl)CH00000000-0000-0000-0000-000000000000muRN);Q@49`?33@𡼤Dȋݕ. AJ 9.[,Pyrimidinyl quinolones?8eEh#. CHEMBL190455xdPD5j .XzCCC1=C[C](=O)[N](C2CCCC2)C3=C1C=NC(=N3)NC4=CC=C(C=C4)N5CCNCC5H00000000-0000-0000-0000-000000000000muRN);Q@49`?33@gQVlN.ۚ. AJ 9.[,Pyrimidinyl quinolones?8eEh#. CHEMBL190303xdPD5j .XtCC(=O)C1=C(C)C2=C(N=C(NC3=NC=CC=C3)N=C2)[N](C4CCCC4)[C]1=OsUzthlןV{޽}9}>ߞ>_~x۟[IOSA$c36b96ec-21df-4181-b918-b0d25670c9fd48 4.34064913 -1.497902150 4.34076643 -0.4979020950 5.20685053 0.001996427770 3.47479963 0.002199477980 2.60379958 -0.4989004430 2.60368085 -1.498900410 1.73709977-2.33661439e-070 1.73580003 1.005699750 0.867900193 1.513499860 0 1.005699990 -0.867468238 1.503192540 -1.73204362 1.000689270 -2.60249615 1.50331140 -3.46701431 0.9905504580 -3.46114016 -0.01463243270 -2.59074759 -0.5070545080 -1.72616959 -0.00449362490000 0.867899597 -0.4977999630 2.60119963 1.512399670 2.59852791 2.51239610 1.78718209 3.09975410 2.09282064 4.053371910 3.09284759 4.054716590 3.40899587 3.105744120 3.47349954 1.007899520 4.33939028 1.50813270 -0.869637966 2.2531893300000 0!0"0#0$0%0&0'0(0)0*0+0,0-0.0/051             !" #!$" %#&$'%(&)'*(+),*-+.,/-0.1/200H00000000-0000-0000-0000-000000000000muRN);Q@49`?33@mIbHJў. AJ 9.[,Pyrimidinyl quinolones?8eEh#. CHEMBL190096xdPD5j .XzCCC1=CC2=C(N=C(NC3=NC=C(C=C3)N4CCNCC4)N=C2)[N](C5CCCC5)[C]1=OH00000000-0000-0000-0000-000000000000muRN);Q@49`?33@!WC{a[!. AJ 9.[,Pyrimidinyl quinolones?8eEh#. CHEMBL190096xdPD5j .XxCC(C)CC[N]1[C](=O)C=C(C)C2=C1N=C(NC3=CC=C(C=C3)N4CCNCC4)N=C2H00000000-0000-0000-0000-000000000000muRN);Q@49`?33@:HCR' . AJ 9.[,Pyrimidinyl quinolones?8eEh#. CHEMBL189980xdPD5j .XCC1=C[C](=O)[N](C2CCCC2)C3=C1C=NC(=N3)NC4=CC=C(C=C4)N5CCN(CC5)C(=O)OC(C)(C)CH00000000-0000-0000-0000-000000000000muRN);Q@49`?33@W:,jEv8 ơ. AJ 9.[,Pyrimidinyl quinolones?8eEh#. CHEMBL190684xdPD5j .X~CN1CCN(CC1)C2=CC=C(NC3=NC4=C(C=N3)C(=C[C](=O)[N]4C5CCCC5)C)C=C2H00000000-0000-0000-0000-000000000000muRN);Q@49`?33@6mA ai<. AJ 9.[,Pyrimidinyl quinolones?8eEh#. CHEMBL192803xdPD5j .XFC(F)(F)C1=C[C](=O)[N](C2CCCC2)C3=C1C=NC(=N3)NC4=CC=C(C=C4)N5CCNCC5H00000000-0000-0000-0000-000000000000muRN);Q@49`?33@/CEH/. AJ 9.[,Pyrimidinyl quinolones?8eEh#. CHEMBL189956xdPD5j .XCC1=C[C](=O)[N](C2CCCC2)C3=C1C=NC(=N3)NC4=CC=C(C=C4)N5CCC(CCCO)CC5H00000000-0000-0000-0000-000000000000muRN);Q@49`?33@4AH?jTnR. AJ 9.[,Pyrimidinyl quinolones?8eEh#. CHEMBL190664xdPD5j .XCC1=C[C](=O)[N](C2CCCC2)C3=C1C=NC(=N3)NC4=CC=C(C=C4)N5CCNC(C)(C)C5H00000000-0000-0000-0000-000000000000muRN);Q@49`?33@`c_d@ak. AJ 9.[,Pyrimidinyl quinolones?8eEh#. CHEMBL190685xdPD5j .XC[C@@H]1CN(C[C@H](C)N1)C2=CC=C(NC3=NC4=C(C=N3)C(=C[C](=O)[N]4C5CCCC5)C)C=C2H00000000-0000-0000-0000-000000000000muRN);Q@49`?33@G.im:D|[8dſ. AJ 9.[,Pyrimidinyl quinolones?8eEh#. CHEMBL364473xdPD5j .XCC1=C[C](=O)[N](C2CCCC2)C3=C1C=NC(=N3)NC4=CC=C(C=C4)N5CCN(CC5)C=OH00000000-0000-0000-0000-000000000000muRN);Q@49`?33@j{^CUQU. AJ 9.[,Pyrimidinyl quinolones?8eEh#. CHEMBL189963xdPD5j .XCC(=O)C1=C(C)C2=C(N=C(NC3=NC=C(C=C3)N4CCNCC4)N=C2)[N](C5CCCC5)[C]1=O OSA$e2f8a2e0-ed6b-4269-9c69-d4c7ab0108b362C1 2.86602545 2.539854050C2 2.86602545 1.539854050O32 1.039854050C4 3.7320509 1.039854050C5 4.59807634 1.539854050C6 4.59807634 2.539854050C7 5.46410179 1.039854050C8 5.46410179 0.03985404220N9 6.35804367 -0.4948072430 C10 7.26411057 0.01903862130 N11 8.12820244 -0.4842957560 C12 8.99614811 0.01236241780 N13 9.00000286 1.012354970 C14 9.86794949 1.509013180C15 10.7320404 1.005678770C16 10.7281866 0.005686215590C17 9.86023998 -0.4909719820N18 11.599987 1.502336980C19 12.4640789 0.9990025760C20 13.3320246 1.495660780N21 13.3358793 2.495653390C22 12.4717875 2.998987670C23 11.6038418 2.502329590N24 7.26411057 1.060669420C25 6.35804367 1.574515340N26 4.59807634 -0.460145950C27 4.59807634 -1.460145950C28 3.78905916 -2.047931190C29 4.09807634 -2.998987670C30 5.09807634 -2.998987670C31 5.40709305 -2.047931190C32 3.7320509 0.03985404220 O33 2.86602545 -0.460145950!H34 3.48602533 2.539854050"H35 2.86602545 3.159853940#H36 2.24602556 2.539854050$H37 5.21807623 2.539854050%H38 4.59807634 3.159853940&H39 3.97807646 2.539854050'H40 8.12581253 -1.10429120(H41 9.87033939 2.129008530)H42 11.2639236 -0.3063809570*H43 9.85785007 -1.11096740+H44 12.0637226 0.5255946520,H45 12.860774 0.5225225090-H46 13.5418301 0.9122383590.H47 13.9430161 1.600968360/H48 13.8740063 2.8035814800H49 12.8721437 3.4723956601H50 12.0750923 3.4754676802H51 11.3940363 3.0857520103H52 10.9928503 2.3970220104H53 6.35087442 2.1944739805H54 5.1505003 -1.1786718406H55 3.47905922 -1.5109953907H56 3.22266102 -2.3001079608H57 3.49162483 -3.1278929709H58 4.16288424 -3.615591290:H59 5.03326893 -3.615591290;H60 5.70452785 -3.127892730<H61 5.97349119 -2.300107960=H62 5.71709299 -1.51099551066            !"# $!%"&#'$(%)&* '+ (,)-*.+/,0-1.2/30415263748596:7;8<9=:>;?<@=A0H00000000-0000-0000-0000-000000000000muRN);Q@49`?33@M+F`zAy>'k. AJ 9.[,Pyrimidinyl quinolones?8eEh#. CHEMBL183855xdPD5j .XnCOC1=CC(=C2C=NC(=NC2=C1C3CCCC3)NC4=CC=C(C=C4)N5CCNCC5)CH00000000-0000-0000-0000-000000000000muRN);Q@49`?33@bhD> ,o ;. AJ 9.[,Pyrimidinyl quinolones?8eEh#. CHEMBL361769xdPD5j .XjCOC1=C(C2CCCC2)C3=NC(=NC=C3C=C1)NC4=CC=C(C=C4)N5CCCC5H00000000-0000-0000-0000-000000000000muRN);Q@49`?33@<[TCB.#P&=>. AJ 9.[,Pyrimidinyl quinolones?8eEh#. CHEMBL359761xdPD5j .XlCC1=C(Br)[C](=O)[N](C2CCCC2)C3=C1C=NC(=N3)NC4=NC=CC=C4H00000000-0000-0000-0000-000000000000muRN);Q@49`?33@RM 'Ͱ. AJ 9.[,Pyrimidinyl quinolones?8eEh#. CHEMBL427535xdPD5j .XCC1=C(Br)[C](=O)[N](C2CCCC2)C3=C1C=NC(=N3)NC4=NC=C(C=C4)N5CCCNCC5H00000000-0000-0000-0000-000000000000muRN);Q@49`?33@~iX?~EPٓ". AJ 9.[,Pyrimidinyl quinolones?8eEh#. CHEMBL360675xdPD5j .XC[N]1[C](=O)C(=CC2=CN=C(NC3=CC=CC=C3)N=C12)C4=C(Cl)C=CC=C4C(F)(F)FH00000000-0000-0000-0000-000000000000muRN);Q@49`?33@+uF9-_R[. AJ 9.[,Pyrimidinyl quinolones?8eEh#. CHEMBL183269xdPD5j .XlCOC1=C(C2CCCC2)C3=NC(=NC=C3C=C1)NC4=CC=C(C=C4)N5CCCCC5H00000000-0000-0000-0000-000000000000muRN);Q@49`?33@íyB/P '. AJ 9.[,Pyrimidinyl quinolones?8eEh#. CHEMBL189978xdPD5j .XCC1CN(CC(C)N1)C2=CN=C(NC3=NC4=C(C=N3)C(=C(Br)[C](=O)[N]4C5CCCC5)C)C=C2H00000000-0000-0000-0000-000000000000muRN);Q@49`?33@JZoEiaN@. AJ 9.[,Pyrimidinyl quinolones?8eEh#. CHEMBL435302xdPD5j .XCCCCOC1=CC2=C(N=C(NC3=NC=C(C=C3)N4CCNCC4)N=C2)[N](C5CCCC5)[C]1=OH00000000-0000-0000-0000-000000000000muRN);Q@49`?33@;JUNҘds/. AJ 9.[,Pyrimidinyl quinolones?8eEh#. CHEMBL189490xdPD5j .XCC1=C(Br)[C](=O)[N](C2CCCC2)C3=C1C=NC(=N3)NC4=NC=C(C=C4)N5CCOCC5H00000000-0000-0000-0000-000000000000muRN);Q@49`?33@JR\pKezV^. AJ 9.[,Pyrimidinyl quinolones?8eEh#. CHEMBL192308xdPD5j .XzBrC1=CC2=C(N=C(NC3=CC=C(C=N3)N4CCNCC4)N=C2)[N](C5CCCC5)[C]1=OH00000000-0000-0000-0000-000000000000muRN);Q@49`?33@Gќ2?. AJ 9.[,Pyrimidinyl quinolones?8eEh#. CHEMBL181323xdPD5j .XC[N]1[C](=O)C(=CC2=CN=C(NC3=CC=C(OCCCC(O)=O)C=C3)N=C12)C4=C(Cl)C=CC=C4Cl OSA$a8b47d78-a668-4eb1-8ea1-3ba92742fb6c54C1 5.46410179-2.250N2 5.46410179-1.250C3 4.59807634-0.750O4 3.7320509-1.250C5 4.598076340.250C6 5.464101790.750C7 6.330127240.250C8 7.22406912 0.7846612930N9 8.13013554 0.2708154320 C10 8.13013554 -0.7708154320 N11 8.99422741 -1.274149780 C12 9.86217403 -0.7774916290 C13 10.7262659 -1.280825970 C14 11.5942116 -0.7841678260C15 11.5980663 0.2158247380O16 12.466012 0.7124829290C17 13.3301039 0.2091485410C18 14.1980505 0.7058067320C19 15.0621424 0.2024723440C20 15.930088 0.6991305350O21 16.7941799 0.1957961320O22 15.9339428 1.699123140C23 10.7339745 0.7191591260C24 9.86602783 0.222500950N25 7.22406912 -1.284661290C26 6.33012724-0.750C27 3.73205090.750C28 3.73205091.750Cl29 4.598076342.250C30 2.866025452.250C3121.750C3220.750 C33 2.866025450.250!Cl34 2.86602545-0.750"H35 4.84410191-2.250#H36 5.46410179 -2.869999890$H37 6.08410168-2.250%H38 5.464101791.370&H39 7.21689987 1.404619810'H40 8.9918375 -1.894145250(H41 10.723876 -1.900821330)H42 12.1299486 -1.096235160*H43 12.9297476 -0.2642593380+H44 13.7267981 -0.267331660,H45 14.5984068 1.17921460-H46 13.8013563 1.182286980.H47 14.6617861 -0.2709355950/H48 15.4588375 -0.27400773800H49 17.3323059 0.50372421701H50 10.7363644 1.3391544802H51 9.33029079 0.53456813103H52 2.86602545 2.8699998904H53 1.46306419 2.0599999405H54 1.46306419 0.439999998057            ! " # !$"%#&$'%(&) '* (+ ),*-+.,/-0.1/20314253647580H00000000-0000-0000-0000-000000000000muRN);Q@49`?33@V_KFz!. AJ 9.[,Pyrimidinyl quinolones?8eEh#. CHEMBL434917xdPD5j .XvC[N]1[C](=O)C(=CC2=CN=C(NC3=CC=CC=C3)N=C12)C4=C(Cl)C=CC=C4OH00000000-0000-0000-0000-000000000000muRN);Q@ =?33@I OC). AJ 9.[,Pyrimidinyl quinolones?8eEh#. CHEMBL337642xdPD5j .XbCC[N]1[C](=O)C=CC2=CN=C(NC3=CC=C(OCCOC)C=C3)N=C12H00000000-0000-0000-0000-000000000000muRN);Q@?33@|Kyln]. AJ 9.[,Pyrimidinyl quinolones?8eEh#. CHEMBL140205xdPD5j .XhCC[N]1[C](=O)C=CC2=CN=C(NC3=CC=C(C=C3)N4CCOCC4)N=C12H00000000-0000-0000-0000-000000000000muRN);Q@j?33@a)*F;'u. AJ 9.[,Pyrimidinyl quinolones?8eEh#. CHEMBL181959xdPD5j .X~C[N]1[C](=O)C(=CC2=CN=C(NC3=CC=CC=C3)N=C12)C4=C(Cl)C=C(N)C=C4ClH00000000-0000-0000-0000-000000000000muRN);Q@M?33@gLx$5. AJ 9.[,2,4-diaminopyrimidines?8eEh#. CHEMBL476578xdPD5j .XC[N]1N=C(C)C2=C1C=C(C=C2)N(C)C3=NC(=NC=C3)NC4=CC(=CC=C4)[S](N)(=O)=OH00000000-0000-0000-0000-000000000000muRN);Q@# Ơ?33@Ţ4 H-. AJ 9.[,2,4-diaminopyrimidines?8eEh#. CHEMBL478409xdPD5j .XC[N]1C=C2C=CC(=CC2=N1)N(C)C3=NC(=NC=C3)NC4=CC(=CC=C4)[S](N)(=O)=OH00000000-0000-0000-0000-000000000000muRN);Q@"?33@aW`GvMCں. AJ 9.[,2,4-diaminopyrimidines?8eEh#. CHEMBL462192xdPD5j .X`CNC1=NC(=NC=C1)NC2=CC=C(C=C2)C3=NC4=C(S3)C=CC=C4H00000000-0000-0000-0000-000000000000muRN);Q@!e`?33@s GOEK. AJ 9.[,2,4-diaminopyrimidines?8eEh#. CHEMBL206400xdPD5j .XvCOC1=C(OC)C(=CC(=C1)NC2=NC3=C(C=C[N]3C4=CC(=CC=C4)N)C=N2)OCH00000000-0000-0000-0000-000000000000muRN);Q@ ?33@ M!;d. AJ 9.[,2,4-diaminopyrimidines?8eEh#. CHEMBL103382xdPD5j .XrCC1=CC(=C(F)C=C1)NC2=NC(=NC=C2)NC3=CC=C(C=C3)[S](N)(=O)=OH00000000-0000-0000-0000-000000000000muRN);Q@ 7@?33@>=tNY4Dy. AJ 9.[,2,4-diaminopyrimidines?8eEh#. CHEMBL254170xdPD5j .X^CC1=C(NC2=NC(=CC=N2)NC3=C4OCOC4=CC=C3Cl)C=CC=C1H00000000-0000-0000-0000-000000000000muRN);Q@?33@MF@j. AJ 9.[,2,4-diaminopyrimidines?8eEh#. CHEMBL372464xdPD5j .XrBrC1=C(NC2=CC3=C(OCO3)C=C2)N=C(NC4=CC=C5[NH]C=NC5=C4)N=C1H00000000-0000-0000-0000-000000000000muRN);Q@ 7@?33@QgC)A[. AJ 9.[,2,4-diaminopyrimidines?8eEh#. CHEMBL379697xdPD5j .XxCOC1=C(OC)C(=CC(=C1)NC2=NC3=C(C=C[N]3C4=CC=C(SC)C=C4)C=N2)OC}{ݨn}wofdvjU<WioW%F.UG9O\ZCS[F#~j] k%m|xȆ}ڻd oZmN.dU $OSA$63981af2-b73f-41dd-86e5-7676413d4ff552 -4.44483328 1.685820940 -5.30718422 1.179509760 -5.29988146 0.1795363720 -6.16821432 -0.326848090 -7.03712749 0.1681170170 -7.90023613 -0.3369010390 -6.16095924 -1.326853040 -5.2941823 -1.825612070 -4.42584944 -1.31922770 -4.42429352 -0.3140840230 -3.55912399 -1.818013190 -2.69380021 -1.316799640 -1.82580018 -1.814699770 -0.95780015 -1.318099980 -0.957799971 -0.310999990000 0.591999948 -0.8146004080-2.28217132e-07 -1.629400250 0.308970243 -2.580471990 1.29280663 -2.786611560 1.60183239 -3.737698080 0.937005103 -4.484736920 1.25015855 -5.434439660 2.22920179 -5.638092040 -0.0468311161 -4.278597830 -0.365840048 -3.325419430 -1.82580018 0.1969003830 -2.69380021 -0.3109996320 -7.0248003 -1.83061790 -7.02044773 -2.830608370 -3.55807257 -2.5680124800 0!0"0#0$0%0&0'0(0)0*0+0,0-0.0/00010203055             !" #!$"%#&$'%(& )'*(+),*-+.,/-0.1/20314253600H00000000-0000-0000-0000-000000000000muRN);Q@ 7@?33@X5 L@ FX. AJ 9.[,2,4-diaminopyrimidines?8eEh#. CHEMBL182843xdPD5j .XCN(CC=C)C1=NC=CC(=N1)NC2=C(C)C=CC(=C2)NC(=O)C3=CC(=NC=C3)N4CCOCC4H00000000-0000-0000-0000-000000000000muRN);Q@?33@mcHCD%j+. AJ 9.[,2,4-diaminopyrimidines?8eEh#. CHEMBL365608xdPD5j .XvBrC1=CN=C(NC2=CC3=C([NH]C=C3)C=C2)N=C1NC4=CC=C5[NH]C=CC5=C4H00000000-0000-0000-0000-000000000000muRN);Q@?33@Rf,H1w)fP4@. AJ 9.[,2,4-diaminopyrimidines?8eEh#. CHEMBL426972xdPD5j .XCC1=C(NC2=NC(=NC=C2)NCCCN3CCCC3)C=C(NC(=O)C4=CC(=NC=C4)N5CCOCC5)C=C1H00000000-0000-0000-0000-000000000000muRN);Q@ 7@?33@^c=EHUd\?. AJ 9.[,2,4-diaminopyrimidines?8eEh#. CHEMBL251796xdPD5j .XrCC1=CC(=C2C=N[NH]C2=C1)NC3=NC(=NC=C3)NC4=CC(=CC=C4)C(N)=OH00000000-0000-0000-0000-000000000000muRN);Q@O?33@#cuJF"I=. AJ 9.[,2,4-diaminopyrimidines?8eEh#. CHEMBL189937xdPD5j .XCN(C1=CC=C(NC(=O)NC2=CC=C(C=C2)C(C)=O)C=C1)C3=NC(=NC=C3)NC4=CC(=CC=C4)C[S](C)(=O)=OH00000000-0000-0000-0000-000000000000muRN);Q@n?33@:6HC[KZ߆. AJ 9.[,2,4-diaminopyrimidines?8eEh#. CHEMBL257625xdPD5j .XtN[S](=O)(=O)C1=CC(=CC=C1)NC2=NC(=CC=N2)NC3=C4OCOC4=CC=C3ClH00000000-0000-0000-0000-000000000000muRN);Q@49`?33@HDQoLwh41. AJ 9.[,2,4-diaminopyrimidines?8eEh#. CHEMBL100391xdPD5j .XnCN(C)CC(O)COC1=CC=C(NC2=NC(=C(Cl)C=N2)NC3=CC=CC=C3)C=C1H00000000-0000-0000-0000-000000000000muRN);Q@49`?33@&ZLע w#. AJ 9.[,2,4-diaminopyrimidines?8eEh#. CHEMBL430507xdPD5j .XCN(C)CC(O)COC1=CC=C(NC2=NC(=CC=N2)N(CC#N)C3=C(Cl)C=CC(=C3)Cl)C=C1H00000000-0000-0000-0000-000000000000muRN);Q@`?33@8JgK̆ ĻZ. AJ 9.[,2,4-diaminopyrimidines?8eEh#. CHEMBL456163xdPD5j .XlOC[C@H](NC1=NC(=C(Cl)C=N1)NC2=N[NH]C=C2)C3=CC=C(F)C=C3H00000000-0000-0000-0000-000000000000muRN);Q@H@?33@WF4nh>". AJ 9.[,2,4-diaminopyrimidines?8eEh#. CHEMBL101119xdPD5j .XnCOC1=CC=C(NC2=CC=NC(=N2)NC3=CC=C(OCC(O)CN(C)C)C=C3)C=C13=yd`}կ Ďۺr-.W`7kd]_dGvAWʻ[vPJ%P "k;?q-vaL.l16+UdSfBH抮7U OSA$13f4fd00-740e-4fce-9739-88c4b827908d57 -3.46701622 -2.992558240 -2.60319972 -3.496365070 -1.73498189 -3.000181670 -1.73352337 -1.994982720 -0.865302444 -1.498741870 0.00147473812 -1.997500060 0.867500067 -1.497499940 0.867500007 -0.4975000020000 -1.02134571e-07 1.005200270 0.867499948 1.512900110 1.7349999 1.005200150 1.73499997.04465108e-080 2.60249662 1.502642870 2.60544705 2.502638580 1.73491824 3.005239250 1.73782086 4.005266190 2.60241866 4.507792950 2.600967885.5077920 1.73421812 6.006535050 1.73276746 7.00653410 0.866017699 7.505277160 2.59806681 7.507789610 2.59661627 8.507788660 1.72986662 9.006531720 3.46191549 9.009043690 3.47294736 4.005192760 3.47887826 3.0000655701.63252862e-05 -3.002699140 -0.868219495 -3.509139780 1.51701915 -1.872499820 3.25090647 1.125728130 0.217043281 7.12933540!0"0#0$0%0&0'0(0)0*0+0,0-0.0/000102030405060708059             ! "!#"$#%$&%'&(' )(*)+*,+-,.-/.0/102132435465768798:00H00000000-0000-0000-0000-000000000000muRN);Q@?33@> ~wH'{X. AJ 9.[,2,4-diaminopyrimidines?8eEh#. CHEMBL101747xdPD5j .XnCN(C)CC(O)COC1=CC=C(NC2=NC(=CC=N2)NC3=C(Cl)C=CC=C3)C=C13Nytl}ծ!ۺr}.Wb3kf]_dGvAW[vPJ-P "k;?:q-vqL.l1>+Ue[BHwW @OSA$330ca4af-037d-4f3b-9db8-f3ba45b309de53 10.3966665 -0.04570460320 9.52698898 -0.5393245820 9.51963711 -1.539297580 8.66466236 -0.03297144170 7.79498434 -0.5265913010 7.78763247 -1.526564360 6.9326582 -0.02023807170 6.06298018 -0.5138577820 5.20065403-0.007504402190 4.32792139 -0.5062679050 3.465543755.97238868e-050 3.46704316 1.000089880 2.60249662 1.502642870 1.7349999 1.005200150 1.73499997.04465108e-080 0.867500007 -0.4975000020000-1.02134571e-07 1.005200270 0.867499948 1.512900110 0.867500067 -1.497499940 1.73352551 -1.997499940 2.60256791 -1.492333770 2.60106897 -0.4923349020 3.46864438 -1.99230790 3.47449684 -2.992321970 2.60545468 -3.497488020 1.73055995 -3.002640010 4.33977604 1.498853450 5.21100903 0.9975867270 8.43437672 -1.906329270 2.60470939 2.252639530 0.21798107 -1.872499940 0!0"0#0$0%0&0'0(0)0*0+0,0-0.0/0001020304055             ! "!#"$#%$&%'&(')(*)+*,+ -, .-/.0/1021324354600H00000000-0000-0000-0000-000000000000muRN);Q@?33@ My8@q0. AJ 9.[,2,4-diaminopyrimidines?8eEh#. CHEMBL382416xdPD5j .X|COC1=C(OC)C(=CC(=C1)NC2=NC3=C(C=C[N]3C4=CC(=CC=C4)CC#N)C=N2)OCH00000000-0000-0000-0000-000000000000muRN);Q@5@?33@p$oPI*I'. AJ 9.[,2,4-diaminopyrimidines?8eEh#. CHEMBL489853xdPD5j .XVOC1=CC=C(NC2=NC(=NC=C2)NC3=CC=C(O)C=C3)C=C1H00000000-0000-0000-0000-000000000000muRN);Q@ ?33@sc2JM. AJ 9.[,2,4-diaminopyrimidines?8eEh#. CHEMBL263837xdPD5j .XCC(C)OC1=C(C=CC(=C1)F)N(C(=O)OC2=C(C)C=CC=C2C)C3=NC(=NC=C3)NC4=CC=C(C=C4)N5CCN(C)CC5H00000000-0000-0000-0000-000000000000muRN);Q@C?33@=鈬CAb!d. AJ 9.[,2,4-diaminopyrimidines?8eEh#. CHEMBL189308xdPD5j .XCN(C1=CC=C(NC(=O)NC2=C(F)C=CC(=C2)C(F)(F)F)C=C1)C3=NC(=NC=C3)NC4=CC(=CC=C4)C[S](C)(=O)=OH00000000-0000-0000-0000-000000000000muRN);Q@ ?33@f(I C:. AJ 9.[,2,4-diaminopyrimidines?8eEh#. CHEMBL381292xdPD5j .XxCCC1=CC=C(C=C1)[N]2C=CC3=CN=C(NC4=CC(=C(OC)C(=C4)OC)OC)N=C23H00000000-0000-0000-0000-000000000000muRN);Q@F?33@p Dyc%gA. AJ 9.[,2,4-diaminopyrimidines?8eEh#. CHEMBL101156xdPD5j .XCN(C)CC(O)COC1=CC=C(NC2=NC(=CC=N2)N(CCC#N)C3=C(Cl)C=CC(=C3)Cl)C=C1H00000000-0000-0000-0000-000000000000muRN);Q@@?33@,JDSJs@. AJ 9.[,2,4-diaminopyrimidines?8eEh#. CHEMBL491647xdPD5j .XCOC1=CC(=CC=C1)NC(=O)C2=CC=C(NC3=NC(=NC=C3F)NC4=CC=C(O)C=C4)C=C2H00000000-0000-0000-0000-000000000000muRN);Q@ ?33@UɃ֣N3A$. AJ 9.[,2,4-diaminopyrimidines?8eEh#. CHEMBL99689xdPD5j .XpCN(C)CC(O)COC1=CC=C(NC2=NC(=CC=N2)NC3=C(C=CC=C3)C#N)C=C1H00000000-0000-0000-0000-000000000000muRN);Q@@?33@-"OSӰfq. AJ 9.[,2,4-diaminopyrimidines?8eEh#. CHEMBL491647xdPD5j .XCOC1=CC=C(NC(=O)C2=CC=C(NC3=NC(=NC=C3F)NC4=CC=C(O)C=C4)C=C2)C=C1H00000000-0000-0000-0000-000000000000muRN);Q@O?33@f1TDW;k2MY. AJ 9.[,2,4-diaminopyrimidines?8eEh#. CHEMBL428630xdPD5j .XpOC(=O)C1=CC=C(NC2=NC=C(C3C=NN=N3)C(=N2)NC4=CC=CC=C4)C=C1H00000000-0000-0000-0000-000000000000muRN);Q@49`?33@{LI1uO,. AJ 9.[,2,4-diaminopyrimidines?8eEh#. CHEMBL99948xdPD5j .XtCN(C)CC(O)COC1=CC=C(NC2=NC=CC(=N2)NC3=C(Cl)C=CC(=C3)C)C=C1H00000000-0000-0000-0000-000000000000muRN);Q@49`?33@}+!EyLF). AJ 9.[,2,4-diaminopyrimidines?8eEh#. CHEMBL208012xdPD5j .XCOC1=C(OC)C(=CC(=C1)NC2=NC=C3C=C[N](C4=CC=CC(=C4)C(=O)NCCCN(C)C)C3=N2)OCH00000000-0000-0000-0000-000000000000muRN);Q@ ?33@~fNzv lv*. AJ 9.[,2,4-diaminopyrimidines?8eEh#. CHEMBL211514xdPD5j .XCOC1=C(C=CC=C1)N(C(=O)OC2=C(C)C=CC=C2C)C3=NC(=NC=C3)NC4=CC=C(C=C4)N5CCN(C)CC5H00000000-0000-0000-0000-000000000000muRN);Q@I?33@} fH'. AJ 9.[,2,4-diaminopyrimidines?8eEh#. CHEMBL461140xdPD5j .XCOC1=C(C=CC(=C1)NC2=NC=CC(=N2)NC3=N[NH]C(=C3)C)C4=NC5=C(S4)C=CC=C5H00000000-0000-0000-0000-000000000000muRN);Q@X`?33@2C{:e7. AJ 9.[,2,4-diaminopyrimidines?8eEh#. CHEMBL207235xdPD5j .X|CCCCC1=CC=C(C=C1)[N]2C=CC3=CN=C(NC4=CC(=C(OC)C(=C4)OC)OC)N=C23H00000000-0000-0000-0000-000000000000muRN);Q@?33@Uy;I9 y. AJ 9.[,2,4-diaminopyrimidines?8eEh#.CHEMBL1097003xdPD5j .XCN(C)C1=NC(=C(C=N1)C(=O)NC2=C(F)C=C(F)C=C2)NC3=CC(=C(OC4=CC(=NC=C4)N)C=C3)FH00000000-0000-0000-0000-000000000000muRN);Q@?33@NǀEڔB &. AJ 9.[,2,4-diaminopyrimidines?8eEh#. CHEMBL207584xdPD5j .XCOC1=C(OC)C(=CC(=C1)NC2=NC3=C(C=C[N]3C4=C(C=CC=C4)C(N)=O)C=N2)OCo{ݨgwofzdvzU_vioE~GxV;o\RR!vZB;~j osnlhΗ=n mmO.Edu lOSA$db4eec03-0be2-4c1a-867c-5f0092868d6152 -4.44483328 1.685820940 -5.30718422 1.179509760 -5.29988146 0.1795363720 -6.16821432 -0.326848090 -7.03712749 0.1681170170 -7.90023613 -0.3369010390 -6.16095924 -1.326853040 -5.2941823 -1.825612070 -4.42584944 -1.31922770 -4.42429352 -0.3140840230 -3.55912399 -1.818013190 -2.69380021 -1.316799640 -1.82580018 -1.814699770 -0.95780015 -1.318099980 -0.957799971 -0.310999990000 0.591999948 -0.8146004080-2.28217132e-07 -1.629400250 0.308970243 -2.580471990 1.29280663 -2.786611560 1.60183239 -3.737698080 0.937005103 -4.484736920 -0.0468311161 -4.278597830 -0.365840048 -3.325419430 1.96085882 -2.042497160 2.93930697 -2.248990060 1.6504631 -1.091889740 -1.82580018 0.1969003830 -2.69380021 -0.3109996320 -7.0248003 -1.83061790 -7.02044773 -2.830608370 -3.55807257 -2.568012480 3.17210388 -2.961945530!3.440346 -1.690904140"0#0$0%0&0'0(0)0*0+0,0-0.0/00010203055             ! " #!$"%#&$'%(&)'*(+) ,*-+.,/-0.1/20314253600H00000000-0000-0000-0000-000000000000muRN);Q@?33@KֲJ>@ǒ=. AJ 9.[,2,4-diaminopyrimidines?8eEh#. CHEMBL471790xdPD5j .XfCN(C)CCNC1=NC(=C(C=N1)C(N)=O)NC2=CC(=CC=C2)C(F)(F)FH00000000-0000-0000-0000-000000000000muRN);Q@?33@ E.=7. AJ 9.[,2,4-diaminopyrimidines?8eEh#. CHEMBL474433xdPD5j .XLCC1=C(NC2=NC(=NC=C2C(N)=O)NCCN)C=CC=C1H00000000-0000-0000-0000-000000000000muRN);Q@?33@uy>=GpeGP>. AJ 9.[,2,4-diaminopyrimidines?8eEh#. CHEMBL98335xdPD5j .XlCN(C)CC(O)COC1=CC=C(NC2=NC(=C(F)C=N2)NC3=CC=CC=C3)C=C1H00000000-0000-0000-0000-000000000000muRN);Q@?33@4<]ChwP1A. AJ 9.[,2,4-diaminopyrimidines?8eEh#. CHEMBL188434xdPD5j .XCN(C1=CC=C(NC(=O)NC2=CC=C(OC(F)(F)F)C=C2)C=C1)C3=NC(=NC=C3)NC4=CC(=CC=C4)[S](N)(=O)=OH00000000-0000-0000-0000-000000000000muRN);Q@?33@:MB޾{k. AJ 9.[,2,4-diaminopyrimidines?8eEh#. CHEMBL516244xdPD5j .XrCSC1=CC(=N[NH]1)NC2=NC(=NC=C2Cl)N[C@@H](CO)C3=CC=C(F)C=C3H00000000-0000-0000-0000-000000000000muRN);Q@?33@pwUN@㿁nn. AJ 9.[,2,4-diaminopyrimidines?8eEh#. CHEMBL100664xdPD5j .XnCOC1=C(NC2=CC=NC(=N2)NC3=CC=C(OCC(O)CN(C)C)C=C3)C=CC=C1H00000000-0000-0000-0000-000000000000muRN);Q@KƠ?33@HcI#%pd. AJ 9.[,2,4-diaminopyrimidines?8eEh#. CHEMBL445162xdPD5j .XtC[S](=O)(=O)C1=CC(=CC=C1)NC2=NC(=CC=N2)NC3=C4OCOC4=CC=C3ClH00000000-0000-0000-0000-000000000000muRN);Q@?33@zWOG6NM(. AJ 9.[,2,4-diaminopyrimidines?8eEh#. CHEMBL430854xdPD5j .XnCN(C)CC(O)COC1=CC=C(NC2=NC(=CC=N2)NC3=CC=C(Cl)C=C3)C=C1H00000000-0000-0000-0000-000000000000muRN);Q@@?33@R֟B_yvus[/~֋}_n?~P?_~f=_~rt:] {$OSA$1ee0d0f4-1fd8-4a4f-95f5-a072874077ba44 3.464092979.42349434e-050 3.46704316 1.000089880 2.60249662 1.502642870 1.7349999 1.005200150 1.73499997.04465108e-080 0.867500007 -0.4975000020000# -0.865298927 -0.5012562270-1.02134571e-07 1.005200270 0.867499948 1.512900110 0.867500067 -1.497499940 1.73352551 -1.997499940 2.64621854 -1.587757830 3.31778193 -2.33496690 2.81450605 -3.201019050 1.83498228 -2.992367980 3.21975517 -4.115225320 3.11448932 -5.111563680 4.02869558 -4.706314560 4.33453989 1.497532610 4.33453941 2.502732750 5.20203972 3.00023270 6.06953955 2.502732520  6.93483877 3.00398850 6.06953955 1.497532490 5.20203972 0.989832640 2.60470939 2.252639530 0.21798107 -1.872499940 4.06381798 -2.257960320000 StereoHydrogen 4.3315897 0.4975369570!0"0#0$0%0&0'0(0)0*0+047              !" #!$"%#&$'%(&)'*(+),*-+.01 H00000000-0000-0000-0000-000000000000muRN);Q@^5@?33@6@K3wь. AJ 9.["amino non-purines?8eEh#. CHEMBL73303xdPD5j .XTCOC1=CC=CC(=C1)NC2=C3C(=C(C)N=C3N=C[NH]2)CH00000000-0000-0000-0000-000000000000muRN);Q@! Ơ?33@2XVGΊu0. AJ 9.["amino non-purines?8eEh#.CHEMBL1098060xdPD5j .XrFC(F)(F)C1=CC=CC(=C1)NC2=C3C=C(CCC4=CC=CC=C4)[NH]C3=NC=N2=l7|}Uw5Oom/zb? U?ǫxa]j>ZmacܺLesx}';KxqiIoW@OSA$0ae5f8d9-0676-4ce5-b7a0-5fb59740c3c045 -0.0760426372 5.196852680 -0.0819436908 4.196869850  -1.08192635 4.202770710  0.918038905 4.190968990 -0.0878446549 3.196887490 0.78119719 2.691720960 0.775343955 1.691707020 -0.0907327086 1.191733480 -0.959774613 1.696899890 -0.962739766 2.70204020 -1.82579994 1.196899890 -1.82579994 0.1968999650 -0.957799971 -0.310999990 000 0.592000067 -0.8145996930 1.59200001 -0.8145413990 2.09194946 0.05151307580 3.09194946 0.05157119040 3.59192872 0.9236081240 4.59195995 0.9237142210 5.09708548 0.06063226980 4.59710646 -0.8114045260 3.59200191 -0.82035934901.29835058e-07 -1.629399660 -0.957799852 -1.318099740 -1.8257997 -1.814699890 -2.69379973-1.31680 -2.69379997 -0.3110000490 -2.47531891 1.571899770 0.231728166 -2.34270334000 0!0"0#0$0%0&0'0(0)0*0+0,048              !" #! $" %#&$'%(&)'*(+),*-+.,/00H00000000-0000-0000-0000-000000000000muRN);Q@! Ơ?33@ԪkKɝ>. AJ 9.["amino non-purines?8eEh#. CHEMBL518383xdPD5j .XCOC1=CC(=C(OCCCN(C)C)C=C1NC2=NC(=C3C=C[NH]C3=N2)NC4=C(C(N)=O)C(=CC=C4)F)ClH00000000-0000-0000-0000-000000000000muRN);Q@! Ơ?33@B_Mল |h. AJ 9.["amino non-purines?8eEh#.CHEMBL1095448xdPD5j .X|NC1=NC2=C(C=C(CC3=C(Cl)C=C(Cl)C=C3)[NH]2)C(=N1)NC4=CC=CC(=C4)FH00000000-0000-0000-0000-000000000000muRN);Q@ ?33@Q-a[EZR믝y. AJ 9.["amino non-purines?8eEh#. CHEMBL360573xdPD5j .XCN(C)[S](=O)(=O)C1=CC=C(NC2=CC(=NC3=C(C=N[N]23)C#N)N[C@H]4CC[C@H](N)CC4)C=C1H00000000-0000-0000-0000-000000000000muRN);Q@ O\ ?33@PѤAt E8Qu. AJ 9.["amino non-purines?8eEh#. CHEMBL178190xdPD5j .XCN(C)[S](=O)(=O)C1=CC=C(NC2=CC(=NC3=C(C=N[N]23)C4CCCC4)N[C@H]5CC[C@H](N)CC5)C=C1H00000000-0000-0000-0000-000000000000muRN);Q@ 1?33@GryF#,. AJ 9.["amino non-purines?8eEh#. CHEMBL178827xdPD5j .XCN(C)[S](=O)(=O)C1=C(Cl)C=C(NC2=CC(=NC3=C(Br)C=N[N]23)N[C@H]4CC[C@H](N)CC4)C=C1H00000000-0000-0000-0000-000000000000muRN);Q@ 1?33@`xE] !. AJ 9.["amino non-purines?8eEh#.CHEMBL1095132xdPD5j .X|NC1=NC(=C2C=C(CC3=CC=C(Cl)C=C3Cl)[NH]C2=N1)NC4=C(F)C=C(Cl)C=C4H00000000-0000-0000-0000-000000000000muRN);Q@j?33@PXJ8 /. AJ 9.["amino non-purines?8eEh#. CHEMBL361833xdPD5j .XN[C@H]1CC[C@@H](CC1)NC2=NC3=C(Br)C=N[N]3C(=C2)NC4=CC=C(C=C4)[S](=O)(=O)C5=CC=CC=C5H00000000-0000-0000-0000-000000000000muRN);Q@/?33@6BH+r}. AJ 9.["amino non-purines?8eEh#. CHEMBL514913xdPD5j .XCCCN1CCC=C(C1)C2=CC(=C(NC3=NC(=C4C=C[NH]C4=N3)NC5=C(C=CC=C5)C(N)=O)C=C2)OCH00000000-0000-0000-0000-000000000000muRN);Q@O?33@6.Ew/Jx . AJ 9.["amino non-purines?8eEh#. CHEMBL476518xdPD5j .XCCCN1CCC=C(C1)C2=CC=C(NC3=NC(=C4C=C[NH]C4=N3)NC5=C(C=CC=C5)C(N)=O)C=C2H00000000-0000-0000-0000-000000000000muRN);Q@z@?33@wF F Z. AJ 9.["amino non-purines?8eEh#.CHEMBL1257670xdPD5j .XhCOC1=CC=C(NC2=NC(=C[N]3C=CN=C23)C4=CN=C(Cl)C=C4)C=C1H00000000-0000-0000-0000-000000000000muRN);Q@ Ġ?33@Rq;VlFʳ'KR. AJ 9.["amino non-purines?8eEh#. CHEMBL367232xdPD5j .XCN(C)[S](=O)(=O)C1=CC=C(NC2=CC(=NC3=C(Cl)C=N[N]23)N[C@H]4CC[C@H](N)CC4)C=C1H00000000-0000-0000-0000-000000000000muRN);Q@ ?33@CFKzV]7U+. AJ 9.["amino non-purines?8eEh#. CHEMBL308594xdPD5j .XRCC1=C(C)C2=C(NC3=CC(=CC=C3)F)N=CN=C2[NH]1H00000000-0000-0000-0000-000000000000muRN);Q@E?33@c#Ba]o. AJ 9.["amino non-purines?8eEh#.CHEMBL1257910xdPD5j .XfCOC1=CC=C(NC2=NC(=C[N]3C=CN=C23)C4=CN=C(F)C=C4)C=C1H00000000-0000-0000-0000-000000000000muRN);Q@@?33@8h |J|09}>. AJ 9.["amino non-purines?8eEh#. CHEMBL306114xdPD5j .XTCC1=C(C)C2=C(NC3=CC(=CC=C3)Cl)N=CN=C2[NH]1H00000000-0000-0000-0000-000000000000muRN);Q@@?33@SAdݔ. AJ 9.["amino non-purines?8eEh#. CHEMBL73413xdPD5j .X\CC1=C(C)C2=C(NC3=CC(=CC(=C3)Cl)Cl)N=CN=C2[NH]1H00000000-0000-0000-0000-000000000000muRN);Q@`?33@JY.VFV. AJ 9.["amino non-purines?8eEh#. CHEMBL203569xdPD5j .XlCCN(CC)C1=NC2=NC=N[N]2C(=C1)NC3=CC=C(C=C3)[S](N)(=O)=OH00000000-0000-0000-0000-000000000000muRN);Q@I?33@2uOFT+%. AJ 9.["amino non-purines?8eEh#. CHEMBL307630xdPD5j .XRCC1=CC=C(NC2=C3C(=C(C)N=C3N=C[NH]2)C)C=C1H00000000-0000-0000-0000-000000000000muRN);Q@f`?33@dd+ËN)@09Ċ. AJ 9.["amino non-purines?8eEh#. CHEMBL365339xdPD5j .XPCOC1=C(OC)C=C(NC2=C3N=CN=C3N=C[NH]2)C=C1H00000000-0000-0000-0000-000000000000muRN);Q@49`?33@ZFpS.. AJ 9.["amino non-purines?8eEh#. CHEMBL203573xdPD5j .XpN[S](=O)(=O)C1=CC=C(NC2=CC(=NC3=NC=N[N]23)NC4CCCCC4)C=C1H00000000-0000-0000-0000-000000000000muRN);Q@$?33@xsBzF`>1f R. AJ 9.["amino non-purines?8eEh#. CHEMBL465004xdPD5j .XCOC1=C(NC2=NC(=C3C=C[NH]C3=N2)NC4=C(C(N)=O)C(=CC(=C4)F)F)C=CC(=C1)N5CCN(CC5)C(C)CH00000000-0000-0000-0000-000000000000muRN);Q@Ơ?33@ԟQE݇,֟R. AJ 9.["amino non-purines?8eEh#. CHEMBL477073xdPD5j .XCCCN1CCCC(C1)C2=CC(=C(NC3=NC(=C4C=C[NH]C4=N3)NC5=C(C=CC(=C5)F)C(N)=O)C=C2)OCH00000000-0000-0000-0000-000000000000muRN);Q@49`?33@FAL;OlU:88. AJ 9.["amino non-purines?8eEh#. CHEMBL476124xdPD5j .XCCCN1CCN(CC1)C2=CC(=C(NC3=NC(=C4C=C[NH]C4=N3)NC5=C(C=CC(=C5)F)C(N)=O)C=C2)OC$}_wmo}ߧ'w~~[7New~{}z}Nrg} 0OSA$445d08dd-fb6c-4516-8732-7bd8fbf287f669 -11.3629503 1.701615330 -10.4984283 1.199019790 -9.63090706 1.696419720 -8.76638508 1.193824050 -8.76346874 0.1886838080 -7.89445114 -0.3165251910 -7.02834988 0.1834060850 -7.02244854 1.183420540 -7.89146614 1.688629150 -6.16382837 -0.319189340 -6.16980839 -1.324316020 -5.29640198 -1.821785810 -4.42584848 -1.319228650 -3.55912304 -1.818013790 -2.69379973-1.31680 -2.69379997 -0.3110000490 -1.82579994 0.1968999650 -0.957799971 -0.310999990000 0.592000067 -0.81459969301.29835058e-07 -1.629399660 -0.957799852 -1.318099740 -1.8257997 -1.814699890 -1.82579994 1.196899890 -2.69182539 1.696899890 -2.68886042 2.702095990 -3.5548892 3.202152730 -4.42385292 2.707213640 -4.42681789 1.702018020 -3.56081915 1.191761260  -5.29577827 1.207136630 -1.82208681 3.200798030 -1.82058859 4.200797080! -0.956811368 2.699501040" -4.42870235 -0.3192008440# -5.29327536 0.1833682510$ -5.2935009 -2.821781640% -4.42602873 -3.319267270& -3.55807137 -2.568012950' 0.231728166 -2.342703340( -1.17628098 1.571899890) -2.46954513 4.576769830* -1.17050838 4.574823380+0,0-0.0/000102030405060708090:0;0<0=0>0?0@0A0B0C0D073  #          !"# $!% "&"#' $($%) &*'+(, )- *.+/,0-1.2/30415263748596:7;8<9=: >;?<@=A>B?C@"DA#EB%FC%GD%H00H00000000-0000-0000-0000-000000000000muRN);Q@?33@AF; Rc. AJ 9.[64- and 4,6-aminopyrimidines?8eEh#.CHEMBL1087075xdPD5j .XCC1=CC(=CC=C1)NC(=O)C2=CC(=C(C)C=C2)NC3=NC4=C(C=CC=C4)[N]3C5=NC=NC(=C5)NH00000000-0000-0000-0000-000000000000muRN);Q@!y ?33@|LM:pL. AJ 9.[64- and 4,6-aminopyrimidines?8eEh#. CHEMBL255718xdPD5j .XzCO\N=C\C1=C(NC2=CC3=C(C=C2)[N](CC4=CC(=CC=C4)Cl)N=C3)N=CN=C1NH00000000-0000-0000-0000-000000000000muRN);Q@ @?33@6`zqO. AJ 9.[64- and 4,6-aminopyrimidines?8eEh#. CHEMBL185633xdPD5j .XvCC1=C(NC2=NC=NC(=C2)Cl)C=C(NC(=O)C3=CC(=NC=C3)N4CCOCC4)C=C1H00000000-0000-0000-0000-000000000000muRN);Q@ ?33@{F3du. AJ 9.[64- and 4,6-aminopyrimidines?8eEh#. CHEMBL186898xdPD5j .XCC1=C(NC2=NC=NC(=C2)NCCCN3CCCC3)C=C(NC(=O)C4=CC(=NC=C4)N5CCOCC5)C=C1H00000000-0000-0000-0000-000000000000muRN);Q@@?33@.B3h+. AJ 9.[64- and 4,6-aminopyrimidines?8eEh#. CHEMBL497477xdPD5j .X~CN(C)\N=C\C1=C(NC2=CC3=C(C=C2)[N](CC4=CC(=CC=C4)F)N=C3)N=CN=C1NH00000000-0000-0000-0000-000000000000muRN);Q@ ?33@_}A}X[}. AJ 9.[64- and 4,6-aminopyrimidines?8eEh#. CHEMBL205680xdPD5j .XZFC1=CC(=CC=C1)COC2=C(Cl)C=C(NC3=NC=NC=C3)C=C2H00000000-0000-0000-0000-000000000000muRN);Q@Ơ?33@c DVG"ȑ7. AJ 9.[64- and 4,6-aminopyrimidines?8eEh#.CHEMBL1097071xdPD5j .XCSC1=NC(=C(C=N1)C(=O)NC2=C(F)C=C(F)C=C2)NC3=CC(=C(OC4=CC(=NC=C4)N)C=C3)FH00000000-0000-0000-0000-000000000000muRN);Q@V?33@ޚg9aOg . AJ 9.[64- and 4,6-aminopyrimidines?8eEh#. CHEMBL101804xdPD5j .XnCOC1=CC=C(NC2=CC(=NC=N2)NC3=CC=C(OCC(O)CN(C)C)C=C3)C=C1H00000000-0000-0000-0000-000000000000muRN);Q@?33@]=+vbH{3}/. AJ 9.[64- and 4,6-aminopyrimidines?8eEh#.CHEMBL1087739xdPD5j .XCC1=C(NC2=NC3=C(C=CC=C3)[N]2C4=NC=NC(=C4)N)C=C(C=C1)C(=O)NC5=CC(=CC=C5)C(F)(F)FH00000000-0000-0000-0000-000000000000muRN);Q@`?33@M@JF. AJ 9.[64- and 4,6-aminopyrimidines?8eEh#.CHEMBL1099039xdPD5j .XNC1=NC=CC(=C1)OC2=CC=C(NC3=NC=NC=C3C(=O)NC4=C(F)C=C(F)C=C4)C=C2FH00000000-0000-0000-0000-000000000000muRN);Q@=?33@Ų NmBt]. AJ 9.[64- and 4,6-aminopyrimidines?8eEh#. CHEMBL317378xdPD5j .XCN(C)CC(O)COC1=CC=C(NC2=NC=NC(=C2)N(CCC#N)C3=C(Cl)C=CC(=C3)Cl)C=C1H00000000-0000-0000-0000-000000000000muRN);Q@49`?33@o9FA>q. AJ 9.[64- and 4,6-aminopyrimidines?8eEh#. CHEMBL461139xdPD5j .X~NC1=C(C(=O)OCCN2CCOCC2)C(=NC=N1)NC3=CC(=C(OCC4=CC=CC=C4)C=C3)ClH00000000-0000-0000-0000-000000000000muRN);Q@?33@'B̊A*I. AJ 9.[64- and 4,6-aminopyrimidines?8eEh#. CHEMBL101887xdPD5j .XnCOC1=C(NC2=CC(=NC=N2)NC3=CC=C(OCC(O)CN(C)C)C=C3)C=CC=C1H00000000-0000-0000-0000-000000000000muRN);Q@?33@ό>ٕeE`"4X. AJ 9.[64- and 4,6-aminopyrimidines?8eEh#. CHEMBL316887xdPD5j .X|CN(C)CC(O)COC1=CC=C(NC2=NC=NC(=C2)NC3=C(C=CC=C3)[N](=O)=O)C=C1H00000000-0000-0000-0000-000000000000muRN);Q@hr?33@3+6;dLi7Vri. AJ 9.[64- and 4,6-aminopyrimidines?8eEh#. CHEMBL101557xdPD5j .XCN(C)CC(O)COC1=CC=C(NC2=NC=NC(=C2)NC3=C(F)C=CC(=C3)C(F)(F)F)C=C13?}fmT,ծr-._i75fMdvӊG[{&~3!;j??=MekN.my;]ovCf(掽Q}W OSA$b2fab7b4-b675-4038-9dd9-2535cd8ce01056 -3.46802521 9.011551860 -2.60272622 8.510295870 -1.73597622 9.009038930 -2.60417724 7.510296820 -1.73887825 7.009040830 -0.872128189 7.507783410 -1.74032938 6.009041790 -0.875030518 5.507785320 -0.876481831 4.507786270 -0.0052006105 4.006491660 -0.00660373922 3.006461380 -0.870447099 2.502638820 -0.867496848 1.502643110 -1.02134571e-07 1.005200270 0.867499948 1.512900110 1.7349999 1.005200150 1.73499997.04465108e-080 0.867500007 -0.4975000020000 0.867500067 -1.497499940 1.73352551 -1.997499940 1.7305603 -3.002696040  0.863786757 -3.501398090 2.59658909 -3.502752780 3.46555281 -3.007813690 3.46851778 -2.002618070 2.60251927 -1.492361310 4.33747816 -1.507736680  3.84259677 -0.6387761240  4.83235931 -2.37669730  5.20643902 -1.012855410 -1.74172843 3.003933430 -1.74916613 4.009050370! -0.871039808 8.257782940" -1.51590669 1.125728490# 0.21798107 -1.872499940$0%0&0'0(0)0*0+0,0-0.0/0001020304050607058            ! "!# "$#%$&%'&(')(*)+*,+-,.-/.0/ 10 21324354657687 900H00000000-0000-0000-0000-000000000000muRN);Q@?33@ C2m&~. AJ 9.[64- and 4,6-aminopyrimidines?8eEh#. CHEMBL101558xdPD5j .XnCN(C)CC(O)COC1=CC=C(NC2=NC=NC(=C2)NC3=C(F)C=CC=C3F)C=C1H00000000-0000-0000-0000-000000000000muRN);Q@?33@j@p|M. AJ 9.[64- and 4,6-aminopyrimidines?8eEh#. CHEMBL418793xdPD5j .XlCN(C)CC(O)COC1=CC=C(NC2=CC(=NC=N2)NC3=C(C)C=CC=C3)C=C1H00000000-0000-0000-0000-000000000000muRN);Q@?33@C _B^6~. AJ 9.[64- and 4,6-aminopyrimidines?8eEh#. CHEMBL317281xdPD5j .XrCN(C)CC(O)COC1=CC=C(NC2=NC=NC(=C2)NC3=C(F)C=C(F)C=C3)C=C1H00000000-0000-0000-0000-000000000000muRN);Q@ Ġ?33@UXߕK "$. AJ 9.[64- and 4,6-aminopyrimidines?8eEh#. CHEMBL99647xdPD5j .XnCN(C)CC(O)COC1=CC=C(NC2=NC=NC(=C2)NC3=C(Cl)C=CC=C3)C=C1H00000000-0000-0000-0000-000000000000muRN);Q@ ?33@@ۘӃ y. AJ 9.[64- and 4,6-aminopyrimidines?8eEh#. CHEMBL318485xdPD5j .XnCN(C)CC(O)COC1=CC=C(NC2=NC=NC(=C2)NC3=CC=C(Cl)C=C3)C=C1H00000000-0000-0000-0000-000000000000muRN);Q@?33@N'YF/. AJ 9.[64- and 4,6-aminopyrimidines?8eEh#. CHEMBL318485xdPD5j .XlCN(C)CC(O)COC1=CC=C(NC2=NC=NC(=C2)NC3=C(F)C=CC=C3)C=C1H00000000-0000-0000-0000-000000000000muRN);Q@?33@l ;IqTTL. AJ 9.[64- and 4,6-aminopyrimidines?8eEh#. CHEMBL318188xdPD5j .XfCN(C)CC(O)COC1=CC=C(NC2=NC=NC(=C2)NC3=CC=CC=C3)C=C1H00000000-0000-0000-0000-000000000000muRN);Q@?33@8)K ֛;. AJ 9.[Aminopyrazines?8eEh#. CHEMBL191003xdPD5j .XfCOCC(=O)NC1=CN=CC(=C1)C2=NC(=CN=C2)NC3=CC(=CC=C3)ClH00000000-0000-0000-0000-000000000000muRN);Q@!e`?33@ O;f[GogBg). AJ 9.[Aminopyrazines?8eEh#. CHEMBL364226xdPD5j .XhOC(=O)CCCNC1=CC(=CN=C1)C2=CN=CC(=N2)NC3=CC=CC(=C3)ClH00000000-0000-0000-0000-000000000000muRN);Q@T?33@`eME*#b. AJ 9.[Aminopyrazines?8eEh#. CHEMBL191312xdPD5j .XVNC1=CC(=CN=C1)C2=CN=CC(=N2)NC3=CC=CC(=C3)ClIu] cal66YKՆU(p`Qw 'an[e0;ْ[%{CoCah.HWdiz]>O˜' 3u@OSA$1658e111-c397-4e99-891a-3b8b2de608b833 -1.73279881-0.003756463530 -0.867500007 0.4975000020000 0.867500305 0.4975005390 0.867499888 1.502700570-1.96808557e-07 2.01040030 -0.867500067 1.502700090 1.73279953-0.003755033020 1.72837639 -1.008945820 2.59367895 -1.510258080 3.46335959 -1.016579990 3.46778274 -0.01138965320 2.60252523 0.5001226660 4.33746004 0.4822307830 4.34481096 1.482203840 5.22047091 1.975810410 5.22786951 2.975814340 4.36849403 3.487220530 3.49283433 2.99361420 3.4765501 1.988601570 2.63351059 3.505046370 -1.73171031 -0.7537556890 -2.38286138 0.3703005020 4.98420525 0.102466375000000000 035               ! "00H00000000-0000-0000-0000-000000000000muRN);Q@ ?33@eZLܚH̄. AJ 9.[Aminopyrazines?8eEh#. CHEMBL372712xdPD5j .XrClC1=CC(=CC=C1)NC2=NC(=CN=C2)C3=CN=CC(=C3)NCCC[N]4C=NC=N4H00000000-0000-0000-0000-000000000000muRN);Q@49`?33@Yt4":O{ث*". AJ 9.[Aminopyrazines?8eEh#. CHEMBL190455xdPD5j .XrClC1=CC=CC(=C1)NC2=CN=CC(=N2)C3=CC(=CN=C3)NCCCC4=CC=CC=C4H00000000-0000-0000-0000-000000000000muRN);Q@49`?33@.ҼFnO. AJ 9.[Odds?8eEh#. CHEMBL203707xdPD5j .XtFC(F)(F)OC1=CC2=C(OC3=C(NC2)C(=NC=N3)NC4=CC=CC(=C4)Br)C=C1H00000000-0000-0000-0000-000000000000muRN);Q@I?33@Z&YB+K`9:. AJ 9.[Odds?8eEh#. CHEMBL384625xdPD5j .XlCOC1=C(OC)C=C2OC3=NC=NC(=C3NCC2=C1)NC4=C(Cl)C=C(F)C=C4H00000000-0000-0000-0000-000000000000muRN);Q@?33@Xę=@kv1%C. AJ 9.["Amino quinazoline?8eEh#. CHEMBL207037xdPD5j .X~COC1=C(CN2CCC[C@@H]2C(N)=O)C=C3C(=NC=NC3=C1)NC4=CC(=C(F)C=C4)ClH00000000-0000-0000-0000-000000000000muRN);Q@?33@p[/;srylamjww^woO? OSA$af2b0cdc-57aa-4ed8-98ed-76f63b3f512066 10.4126339 -2.981657030 9.54582214 -3.480292320 8.6776247 -2.973785880 7.81082344 -3.482678410 7.81220675 -4.487878320 8.68039036 -4.984184740 9.54720497 -4.485491750 6.94264364 -2.986428740 6.07878876 -3.490169760 5.21060896 -2.993919850 4.34152842 -3.499019860 4.34735346 -4.499002930 3.46667099 -3.004105330 3.46971297 -1.998965260 2.60372519 -1.498899820 2.60380077 -0.4988996680 3.47480059 0.002300684110 3.47350001 1.007900710 2.60119987 1.512300490 1.73580003 1.005600090 0.867900014 1.5135000900 1.005599980000 0.867900729 -0.4977004830 1.73710048 2.0428665e-080 -0.865292609 -0.5012671350 -1.77820075 -0.09303329890 -2.44757009 -0.8379810450 -1.94791317 -1.706126090 -2.35501432 -2.619509220 -1.7675519 -3.428760770 -0.773263335 -3.321739910 -0.182746232 -4.135199550! -0.586517394 -5.055680270"0.000944972038 -5.864932060# -1.58679771 -5.154447080$ -2.177315 -4.340987210% -0.965334892 -1.496700530& 4.33879423 -1.493865010' 5.20483255 -1.993905190( 1.95417774 -1.87385070)0*0+0,0-0.0/000102030405060708090:0;0<0=0>0?0@0A071  '        % !"$#$ % !&!"'!#(#$)%* &+&',(-).*/+0,1-2.3/ 405162738495:6;7<8=9>: ?; @<#A=#B>$C?$D@&EA'F00H00000000-0000-0000-0000-000000000000muRN);Q@?33@[ɛKNb*/. AJ 9.["Amino quinazoline?8eEh#. CHEMBL554xdPD5j .XC[S](=O)(=O)CCNCC1=CC=C(O1)C2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(OCC5=CC(=CC=C5)F)C=C4)ClH00000000-0000-0000-0000-000000000000muRN);Q@ ?33@9!6@cKjH. AJ 9.["Amino quinazoline?8eEh#. CHEMBL215205xdPD5j .XC[S](=O)(=O)CCOCC1=CC=C(O1)C2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(OCC5=CC(=CC=C5)F)C=C4)ClH00000000-0000-0000-0000-000000000000muRN);Q@Ơ?33@/(w{JP^&v$. AJ 9.["Amino quinazoline?8eEh#. CHEMBL491064xdPD5j .XbC\C=C\C(=O)CC1=CC2=C(C=C1)N=CN=C2NC3=CC(=CC=C3)BrH00000000-0000-0000-0000-000000000000muRN);Q@@?33@^[ F`єK4. AJ 9.[Odds?8eEh#. CHEMBL367363xdPD5j .XvCSC1=CC(=CC=C1)NC2=C[N]3C=C(C=CC3=N2)C(=O)C4=C(Cl)C=CC=C4ClH00000000-0000-0000-0000-000000000000muRN);Q@?33@B+*Kɚoބ. AJ 9.[Odds?8eEh#. CHEMBL181289xdPD5j .XNC(=N)N[S](=O)(=O)C1=CC=C(NC2=C[N]3C=C(C=CC3=N2)C(=O)C4=C(Cl)C=CC=C4Cl)C=C1H00000000-0000-0000-0000-000000000000muRN);Q@hr?33@ [jH։}?. AJ 9.[Odds?8eEh#. CHEMBL181323xdPD5j .X~OC(=O)C1=CC=C(NC2=C[N]3C=C(C=CC3=N2)C(=O)C4=C(Cl)C=CC=C4Cl)C=C1H00000000-0000-0000-0000-000000000000muRN);Q@49`?33@sxBR . AJ 9.[Odds?8eEh#. CHEMBL509730xdPD5j .XVCC1=C(NC2=NC(=C[NH]2)C3=CN=CC=C3)C=C(N)C=C1H00000000-0000-0000-0000-000000000000muRN);Q@@?33@?Cٲ6. AJ 9.[Odds?8eEh#. CHEMBL489524xdPD5j .XfCC1=C(NC2=NC(=C[NH]2)C3=CC=NC=C3)C=C(C=C1)[N](=O)=OH00000000-0000-0000-0000-000000000000muRN);Q@49`?33@}`ĭM8^'. AJ 9.[Odds?8eEh#. 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