by Marina Chenery | Oct 6, 2020
Case Studies In silico Guided Hit-to-Candidate Value A key principle in the efficient progression of compounds from Hit to Candidate is effective decision making. StarDrop enabled the project team to: Rapidly focus resources on low risk chemistry Identify potential...
by Marina Chenery | Oct 5, 2020
Case Studies Improving Metabolic Stability Improving Metabolic Stability This project’s goal was to employ a ‘fast-follower’ strategy to improve on a competitor compound that had problems with poor oral bioavailability and short and variable...
by Marina Chenery | Sep 21, 2020
Case Studies Rapid Focus in Lead Optimisation Value The application of StarDrop to this project could have resulted in a 90% saving in compounds synthesised. No in vitro ADME screens were used in the selection process and, furthermore, a 70% saving in in vivo testing...