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<IncrementChange>1</IncrementChange> <Temporary>0</Temporary> </Rule> </Rule> LE5L5\ l5HT1A IC50 (uM)UU<Rule> <Rule> <Column>5HT1A IC50 (uM)</Column> <UserCreated>0</UserCreated> <ValueType>0</ValueType> <Value></Value> <IncrementStart>1</IncrementStart> <IncrementChange>1</IncrementChange> <Temporary>0</Temporary> </Rule> </Rule> dOzJ}{01zArOb!a14.8uOpB]Tc!jCC(CCCN2C(=O)CC1(CCCC1)CC2=O)N3CCN(CC3)C4=NC=C(C=N4)F 'OSA$78385169-d15d-49c0-861d-ee63b05241fe62C19.5 -2.165063620C29 -1.299038050C39.5 -0.4330126940C410.5 -0.4330126940C511 0.4330126940N612 0.4330126940C712.5 1.299038050O812 2.165063620C913.5 1.299038050 C1014 0.4330126940 C11 14.5877857 1.242029670 C12 15.5388422 0.9330127240 C13 15.5388422 -0.06698729840 C14 14.5877857 -0.3760042790C1513.5 -0.4330126940C1612.5 -0.4330126940O1712 -1.299038050N188 -1.299038050C197.5 -0.4330126940C206.5 -0.4330126940N216 -1.299038050C226.5 -2.165063620C237.5 -2.165063620C245 -1.299038050N254.5 -0.4330126940C263.5 -0.4330126940C273 -1.299038050C283.5 -2.165063620N294.5 -2.165063620 F302 -1.299038050H31 8.96306419 -2.475063560H32 9.81000042 -2.701999430 H33 10.0369358 -1.855063680!H34 8.68999958 -1.835973740"H35 9.6076622 0.1775681080#H36 8.91739082 -0.2209601850$H37 10.3923378 -1.043593530%H38 11.0826092 -0.6450651880&H39 11.1076622 1.043593530'H40 10.4173908 0.6450651880(H41 14.0826092 1.511090520)H42 13.3923378 1.909618850*H43 14.839963 1.808427810+H44 14.0508499 1.552029850,H45 16.1554451 0.868205070-H46 15.6677475 1.539464240.H47 15.6677475 -0.6734387870/H48 16.1554451-0.0021796531500H49 14.0508499 -0.686004401H50 14.839963 -0.94240242202H51 13.3923378 -1.0435935303H52 14.0826092 -0.64506518804H53 8.08260918 -0.22096018505H54 7.39233828 0.17756810806H55 6.60766172 0.17756810807H56 5.91739035 -0.22096018508H57 5.91739035 -2.3771159609H58 6.60766172 -2.775644540:H59 7.39233828 -2.775644540;H60 8.08260918 -2.377115960<H61 3.19000006 0.103923060=H62 3.19000006 -2.70199943065             !" #!$"%#&$'%(&)'*(+), *- +. ,/ -0 .1 /2 03 1425364758697:8;9<:=;><?=@0H00000000-0000-0000-0000-000000000000LE5L5\ l0.0468{sF15Em}01zArOb!a78.3uOpB]Tc!dCC3(C)CC(=O)N(CCCCN1CCN(CC1)C2=NC=C(C=N2)F)C(=O)C3 $OSA$1627a220-3c49-4721-8c74-87b3c96b683c55C1 4.2320509 6.433012490C2 3.7320509 5.566987510C3 3.2320509 6.433012490C4 4.59807634 5.066987510C5 4.59807634 4.066987510O6 5.46410179 3.566987280N7 3.7320509 3.566987280C8 3.7320509 2.566987280C9 4.59807634 2.066987280 C10 4.59807634 1.066987280 C11 5.46410179 0.5669872760 N12 5.46410179 -0.4330126940 C13 4.59807634 -0.9330127240 C14 4.59807634 -1.933012720N15 5.46410179 -2.433012720C16 6.33012724 -1.933012720C17 6.33012724 -0.9330127240C18 5.46410179 -3.433012720N19 6.33012724 -3.933012720C20 6.33012724 -4.933012490C21 5.46410179 -5.433012490C22 4.59807634 -4.933012490N23 4.59807634 -3.933012720 F24 5.46410179 -6.433012490C25 2.86602545 4.066987510O262 3.566987280C27 2.86602545 5.066987510H28 4.7689867 6.123012540H29 4.54205084 6.969948290H30 3.69511533 6.743012430H31 3.76898646 6.743012430H32 2.92205071 6.969948290 H33 2.69511533 6.123012540!H34 5.20865726 4.959325790"H35 4.81012869 5.649597170#H36 3.12146997 2.674649240$H37 3.51999831 1.984377860%H38 5.20865726 1.959325430&H39 4.81012869 2.649596690'H40 3.98749542 1.174649120(H414.386024 0.4843778610)H42 6.07468271 0.4593254030*H43 5.67615414 1.149596690+H444.386024 -0.3504033090,H45 3.98749542 -1.040674570-H46 3.98749542 -1.825350880.H474.386024 -2.515622140/H48 6.54217958 -2.5156221400H49 6.94070816 -1.8253508801H50 6.94070816 -1.0406745702H51 6.54217958 -0.35040330903H52 6.86706305 -5.2430124304H53 4.06114054 -5.2430124305H54 2.65397286 5.6495971706H55 2.25544453 4.95932579057           ! "!#"$#%$&%'&( ') (* )+ *, +- ,. -/ .0/1021324354657680H00000000-0000-0000-0000-000000000000LE5L5\ l0.205 nҒeO#01zArOb!a40.1uOpB]Tc!jCC3(C)CC(=O)N(CCCC(N1CCN(CC1)C2=NC=C(C=N2)F)C)C(=O)C3 OSA$c4d32c9f-055a-4064-9f1f-8ecb49c407cd58C1 4.2320509 6.433012490C2 3.7320509 5.566987510C3 3.2320509 6.433012490C4 4.59807634 5.066987510C5 4.59807634 4.066987510O6 5.46410179 3.566987280N7 3.7320509 3.566987280C8 3.7320509 2.566987280C9 4.59807634 2.066987280 C10 4.59807634 1.066987280 C11 5.46410179 0.5669872760 N12 5.46410179 -0.4330126940 C13 4.59807634 -0.9330127240 C14 4.59807634 -1.933012720N15 5.46410179 -2.433012720C16 6.33012724 -1.933012720C17 6.33012724 -0.9330127240C18 5.46410179 -3.433012720N19 6.33012724 -3.933012720C20 6.33012724 -4.933012490C21 5.46410179 -5.433012490C22 4.59807634 -4.933012490N23 4.59807634 -3.933012720 F24 5.46410179 -6.433012490C25 6.33012724 1.066987280C26 2.86602545 4.066987510O272 3.566987280C28 2.86602545 5.066987510H29 4.7689867 6.123012540H30 4.54205084 6.969948290H31 3.69511533 6.743012430H32 3.76898646 6.743012430 H33 2.92205071 6.969948290!H34 2.69511533 6.123012540"H35 5.20865726 4.959325790#H36 4.81012869 5.649597170$H37 3.12146997 2.674649240%H38 3.51999831 1.984377860&H39 5.20865726 1.959325430'H40 4.81012869 2.649596690(H41 3.98749542 1.174649120)H424.386024 0.4843778610*H43 6.0010376 0.2569872740+H444.386024 -0.3504033090,H45 3.98749542 -1.040674570-H46 3.98749542 -1.825350880.H474.386024 -2.515622140/H48 6.54217958 -2.5156221400H49 6.94070816 -1.8253508801H50 6.94070816 -1.0406745702H51 6.54217958 -0.35040330903H52 6.86706305 -5.2430124304H53 4.06114054 -5.2430124305H54 6.64012718 0.53005152906H55 6.86706305 1.3769872207H56 6.0201273 1.6039230808H57 2.65397286 5.6495971709H58 2.25544453 4.95932579060            ! "!#"$#%$&%'&(') (* )+ *, +- ,. -/ .0/102132435465768798:9;0H00000000-0000-0000-0000-000000000000LE5L5\ l0.087YM&AF^j s"CYP3A4 T1/2 (min)0@?20@??UU`@440@??UU`@D60@??@N"CYP3A4 T1/2 (min)Calibri@(2d((((((((((((((((((Calibri@(2d((((((((((((((((((@N@4@$(_J{ Ju Count 0@?2@??@4@??@6@??@8@??@ @???@??@@??@@??@ CountCalibri@(2d((((((((((((((((((Calibri@(2d((((((((((((((((((@ @?1ؕEnLo5l2G(`C:]H(_J{ Ju1ؕEnLoData Set!!ffVR@W1CC<<<<<<5l2G(`C:]H@V4Count vs CYP3A4 T1/2 (min)Calibri@(2d((((((VR@W1p22 serialization::archive 11 1 0 0 0 0 0 0 0 1 0 1 0 1 1Calibri@(2d((((((@$@$@$@$4Count vs CYP3A4 T1/2 (min)2WW@*?