by Marina Chenery | Nov 21, 2013 | Multi-Parameter Optimisation, Publications and presentations
Summary In this drug optimisation article, coauthored with Pfizer we discuss new ‘rule induction’ methods. These explore complex data to find interpretable, multi-parameter rules, tailored to any drug discovery objective, and are useful in identifying...
by Marina Chenery | Apr 18, 2013 | Multi-Parameter Optimisation, Publications and presentations
Finding Multi-parameter Rules for Successful Optimization Matt gave this presentation at the ACS National Spring Meeting 2013 in New Orleans. Abstract Multi-parameter optimization (MPO) is increasingly used in drug discovery to prioritise compounds against a profile...
by Marina Chenery | Oct 23, 2012 | General, Multi-Parameter Optimisation, Publications and presentations
Summary There are many different definitions of ‘drug-like’, with rules proposed based on property trends seen in successful drugs. In the paper we review the strengths and weaknesses of these different definitions of ‘drug-like’ properties and...
by Marina Chenery | Sep 30, 2011 | Multi-Parameter Optimisation, Publications and presentations
Matt Segall, Optibrium’s CEO, gave a presentation on Multi-parameter Optimisation in Drug Discovery at ELRIG Drug Discovery. Abstract A high quality drug must exhibit a balance of many properties, including potency, ADME and safety. Identifying an optimal...
by Marina Chenery | Sep 6, 2011 | Multi-Parameter Optimisation, Publications and presentations
In this multi-parameter optimisation review, we survey the range of methods used for MPO in drug discovery, compare their strengths and weaknesses and present some example applications. Summary To be successful as a drug, a compound must have a delicate balance of...